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Epigenetic inhibition of class I histone deacetylases by MS-275 attenuates diabetic skeletal muscle atrophy via Akt/ARK5-FoxO and myostatin-Smad signaling.

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Title: Epigenetic inhibition of class I histone deacetylases by MS-275 attenuates diabetic skeletal muscle atrophy via Akt/ARK5-FoxO and myostatin-Smad signaling.
Authors: Son Y; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea.; Department of Biomedical Sciences, Graduate School of Ajou University, Suwon, Republic of Korea., Byeon HE; Institute of Medical Science, Ajou University School of Medicine, Suwon, Republic of Korea., Choi SE; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea., Kim Y; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea.; Department of Biomedical Sciences, Graduate School of Ajou University, Suwon, Republic of Korea., Heo YJ; Institute of Medical Science, Ajou University School of Medicine, Suwon, Republic of Korea., Kwon SB; Department of Life Science, Hallym University, Chuncheon, Gangwon-do, Republic of Korea., Choi J; Department of Physiology, Ajou University School of Medicine, Suwon, Republic of Korea., Han SJ; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea., Jeon J; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea., Kim HJ; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea., Lee N; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea., Lee KW; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea.
Source: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2026 Mar 09; Vol. 17, pp. 1788603. Date of Electronic Publication: 2026 Mar 09 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Epigenetic inhibition of class I histone deacetylases by MS-275 attenuates diabetic skeletal muscle atrophy via Akt/ARK5-FoxO and myostatin-Smad signaling.
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  Data: <searchLink fieldCode="AU" term="%22Son+Y%22">Son Y</searchLink>; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea.; Department of Biomedical Sciences, Graduate School of Ajou University, Suwon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Byeon+HE%22">Byeon HE</searchLink>; Institute of Medical Science, Ajou University School of Medicine, Suwon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+SE%22">Choi SE</searchLink>; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+Y%22">Kim Y</searchLink>; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea.; Department of Biomedical Sciences, Graduate School of Ajou University, Suwon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Heo+YJ%22">Heo YJ</searchLink>; Institute of Medical Science, Ajou University School of Medicine, Suwon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kwon+SB%22">Kwon SB</searchLink>; Department of Life Science, Hallym University, Chuncheon, Gangwon-do, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+J%22">Choi J</searchLink>; Department of Physiology, Ajou University School of Medicine, Suwon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Han+SJ%22">Han SJ</searchLink>; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jeon+J%22">Jeon J</searchLink>; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+HJ%22">Kim HJ</searchLink>; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+N%22">Lee N</searchLink>; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+KW%22">Lee KW</searchLink>; Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Republic of Korea.
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  Data: <searchLink fieldCode="JN" term="%22101555782%22">Frontiers in endocrinology</searchLink> [Front Endocrinol (Lausanne)] 2026 Mar 09; Vol. 17, pp. 1788603. <i>Date of Electronic Publication: </i>2026 Mar 09 (<i>Print Publication: </i>2026).
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              Text: 2026 Mar 09
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