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A toolkit for generating virtual brightfield images of histological and immunohistochemical stains from multiplexed data with AI-based channel selection and image enhancement.

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Title: A toolkit for generating virtual brightfield images of histological and immunohistochemical stains from multiplexed data with AI-based channel selection and image enhancement.
Authors: Whitmarsh T; Institute of Astronomy, University of Cambridge, Cambridge, United Kingdom., Al Sa'd M; Institute of Astronomy, University of Cambridge, Cambridge, United Kingdom., González Solares E; Institute of Astronomy, University of Cambridge, Cambridge, United Kingdom., Molaeinezhad A; Institute of Astronomy, University of Cambridge, Cambridge, United Kingdom., Irfan MO; Institute of Astronomy, University of Cambridge, Cambridge, United Kingdom., Mulvey C; CRUK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom., Paez-Ribes M; CRUK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom., Fatem A; CRUK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom., Cope W; Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom., Hua K; CRUK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom., Hannon G; CRUK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom., Bressan D; CRUK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom., Walton N; Institute of Astronomy, University of Cambridge, Cambridge, United Kingdom.
Source: Frontiers in bioinformatics [Front Bioinform] 2026 Mar 09; Vol. 6, pp. 1765143. Date of Electronic Publication: 2026 Mar 09 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 9918227263306676 Publication Model: eCollection Cited Medium: Internet ISSN: 2673-7647 (Electronic) Linking ISSN: 26737647 NLM ISO Abbreviation: Front Bioinform Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: A toolkit for generating virtual brightfield images of histological and immunohistochemical stains from multiplexed data with AI-based channel selection and image enhancement.
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  Data: <searchLink fieldCode="AU" term="%22Whitmarsh+T%22">Whitmarsh T</searchLink>; Institute of Astronomy, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Al+Sa'd+M%22">Al Sa'd M</searchLink>; Institute of Astronomy, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22González+Solares+E%22">González Solares E</searchLink>; Institute of Astronomy, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Molaeinezhad+A%22">Molaeinezhad A</searchLink>; Institute of Astronomy, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Irfan+MO%22">Irfan MO</searchLink>; Institute of Astronomy, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Mulvey+C%22">Mulvey C</searchLink>; CRUK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Paez-Ribes+M%22">Paez-Ribes M</searchLink>; CRUK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Fatem+A%22">Fatem A</searchLink>; CRUK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cope+W%22">Cope W</searchLink>; Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hua+K%22">Hua K</searchLink>; CRUK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hannon+G%22">Hannon G</searchLink>; CRUK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bressan+D%22">Bressan D</searchLink>; CRUK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Walton+N%22">Walton N</searchLink>; Institute of Astronomy, University of Cambridge, Cambridge, United Kingdom.
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  Data: <searchLink fieldCode="JN" term="%229918227263306676%22">Frontiers in bioinformatics</searchLink> [Front Bioinform] 2026 Mar 09; Vol. 6, pp. 1765143. <i>Date of Electronic Publication: </i>2026 Mar 09 (<i>Print Publication: </i>2026).
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        Value: 10.3389/fbinf.2026.1765143
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