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Structural Elucidation and Engineering of the (S)-scoulerine 2-O-Methyltransferase Enabling Regioselective Epiberberine Biosynthesis in Coptis chinensis.

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Title: Structural Elucidation and Engineering of the (S)-scoulerine 2-O-Methyltransferase Enabling Regioselective Epiberberine Biosynthesis in Coptis chinensis.
Authors: Song J; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, China., Liu D; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, China., Chen S; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China., Tan Y; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China., Wang S; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China., Li S; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China., Qin Y; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China., Li G; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China., Tian X; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China., Yang L; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China., Yuan C; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China., Gou J; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, China., Huang W; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, China., Chen S; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, China.; Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Liu Y; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, China.
Source: Plant biotechnology journal [Plant Biotechnol J] 2026 Jul; Vol. 24 (7), pp. 4528-4545. Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article
Journal Info: Publisher: Wiley on behalf of the Society for Experimental Biology, Association of Applied Biologists Country of Publication: England NLM ID: 101201889 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1467-7652 (Electronic) Linking ISSN: 14677644 NLM ISO Abbreviation: Plant Biotechnol J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Structural Elucidation and Engineering of the (S)-scoulerine 2-O-Methyltransferase Enabling Regioselective Epiberberine Biosynthesis in Coptis chinensis.
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  Data: <searchLink fieldCode="AU" term="%22Song+J%22">Song J</searchLink>; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Liu+D%22">Liu D</searchLink>; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Tan+Y%22">Tan Y</searchLink>; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Qin+Y%22">Qin Y</searchLink>; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Li+G%22">Li G</searchLink>; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Tian+X%22">Tian X</searchLink>; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Yuan+C%22">Yuan C</searchLink>; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Gou+J%22">Gou J</searchLink>; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Huang+W%22">Huang W</searchLink>; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, China.; Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, China.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley+on+behalf+of+the+Society+for+Experimental+Biology%2C+Association+of+Applied+Biologists%22">Wiley on behalf of the Society for Experimental Biology, Association of Applied Biologists </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101201889 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1467-7652 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214677644%22">14677644 </searchLink><i>NLM ISO Abbreviation: </i>Plant Biotechnol J <i>Subsets: </i>MEDLINE
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        Value: 10.1111/pbi.70650
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              Text: 2026 Jul
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