Structural Elucidation and Engineering of the (S)-scoulerine 2-O-Methyltransferase Enabling Regioselective Epiberberine Biosynthesis in Coptis chinensis.

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Title: Structural Elucidation and Engineering of the (S)-scoulerine 2-O-Methyltransferase Enabling Regioselective Epiberberine Biosynthesis in Coptis chinensis.
Authors: Song J; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, China., Liu D; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, China., Chen S; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China., Tan Y; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China., Wang S; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China., Li S; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China., Qin Y; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China., Li G; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China., Tian X; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China., Yang L; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China., Yuan C; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China., Gou J; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, China., Huang W; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, China., Chen S; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, China.; Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Liu Y; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, China.
Source: Plant biotechnology journal [Plant Biotechnol J] 2026 Jul; Vol. 24 (7), pp. 4528-4545. Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article
Journal Info: Publisher: Wiley on behalf of the Society for Experimental Biology, Association of Applied Biologists Country of Publication: England NLM ID: 101201889 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1467-7652 (Electronic) Linking ISSN: 14677644 NLM ISO Abbreviation: Plant Biotechnol J Subsets: MEDLINE
Database: MEDLINE Ultimate
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