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High-Sensitivity Cardiac Troponin T-gen6 Assay in Suspected Myocardial Infarction: Diagnostic Accuracy, Cutoffs, and Clinical Implications.

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Title: High-Sensitivity Cardiac Troponin T-gen6 Assay in Suspected Myocardial Infarction: Diagnostic Accuracy, Cutoffs, and Clinical Implications.
Authors: Koechlin L; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; Department of Cardiac Surgery, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy; Department of Cardiac Surgery, University Hospital Zürich, University of Zürich, Zurich, Switzerland. Electronic address: luca.koechlin@usz.ch., Lopez-Ayala P; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy., Thurston AJF; British Heart Foundation Centre for Cardiovascular Sciences, University of Edinburgh, Edinburgh, United Kingdom., Tew YY; British Heart Foundation Centre for Cardiovascular Sciences, University of Edinburgh, Edinburgh, United Kingdom., O'Brien R; Emergency Medicine Research Group Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom., Gray A; Emergency Medicine Research Group Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom., Bima P; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy; Department of Medical Sciences, University of Turin, Turin, Italy., Kaplan E; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy., Miró Ò; GREAT Network, Roma, Italy; Emergency Department, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute, University of Barcelona, Barcelona, Catalonia, Spain., Christ M; Emergency Department, Kantonsspital Luzern, Lucerne, Switzerland., Keller DI; Emergency Department, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Martin-Sanchez JF; GREAT Network, Roma, Italy; Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain., Morawiec B; GREAT Network, Roma, Italy; Second Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Katowice, Katowice, Poland., Parenica J; Department of Cardiology, Brno University Hospital, Brno, Czech Republic., Herraiz Recuenco L; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy., Huré G; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy., Wildi K; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy; Cantonal Hospital Aarau, Department of Intensive Care, Aarau, Switzerland., Crisanti L; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy., Spagnuolo C; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy., Glaeser J; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy., Caubergh C; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland., Rentsch K; Laboratory Medicine, University Hospital Basel, University of Basel, Basel, Switzerland., Slankamenac K; Emergency Department, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Rodriguez Cetina Biefer H; Department of Cardiac Surgery, University Hospital Zürich, University of Zürich, Zurich, Switzerland., Dzemali O; Department of Cardiac Surgery, University Hospital Zürich, University of Zürich, Zurich, Switzerland., Strebel I; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy., Mahfoud F; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland., Mills NL; GREAT Network, Roma, Italy; British Heart Foundation Centre for Cardiovascular Sciences, University of Edinburgh, Edinburgh, United Kingdom., Boeddinghaus J; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy; British Heart Foundation Centre for Cardiovascular Sciences, University of Edinburgh, Edinburgh, United Kingdom., Mueller C; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy. Electronic address: Luca.koechlin@usb.ch.
Corporate Authors: APACE and POC-ET Investigators
Source: Journal of the American College of Cardiology [J Am Coll Cardiol] 2026 May 05; Vol. 87 (17), pp. 2236-2257. Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Biomedical Country of Publication: United States NLM ID: 8301365 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-3597 (Electronic) Linking ISSN: 07351097 NLM ISO Abbreviation: J Am Coll Cardiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: High-Sensitivity Cardiac Troponin T-gen6 Assay in Suspected Myocardial Infarction: Diagnostic Accuracy, Cutoffs, and Clinical Implications.
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  Data: <searchLink fieldCode="AU" term="%22Koechlin+L%22">Koechlin L</searchLink>; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; Department of Cardiac Surgery, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy; Department of Cardiac Surgery, University Hospital Zürich, University of Zürich, Zurich, Switzerland. Electronic address: luca.koechlin@usz.ch.<br /><searchLink fieldCode="AU" term="%22Lopez-Ayala+P%22">Lopez-Ayala P</searchLink>; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Thurston+AJF%22">Thurston AJF</searchLink>; British Heart Foundation Centre for Cardiovascular Sciences, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tew+YY%22">Tew YY</searchLink>; British Heart Foundation Centre for Cardiovascular Sciences, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22O'Brien+R%22">O'Brien R</searchLink>; Emergency Medicine Research Group Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gray+A%22">Gray A</searchLink>; Emergency Medicine Research Group Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bima+P%22">Bima P</searchLink>; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Kaplan+E%22">Kaplan E</searchLink>; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Miró+Ò%22">Miró Ò</searchLink>; GREAT Network, Roma, Italy; Emergency Department, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute, University of Barcelona, Barcelona, Catalonia, Spain.<br /><searchLink fieldCode="AU" term="%22Christ+M%22">Christ M</searchLink>; Emergency Department, Kantonsspital Luzern, Lucerne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Keller+DI%22">Keller DI</searchLink>; Emergency Department, University Hospital Zurich, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Martin-Sanchez+JF%22">Martin-Sanchez JF</searchLink>; GREAT Network, Roma, Italy; Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Morawiec+B%22">Morawiec B</searchLink>; GREAT Network, Roma, Italy; Second Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Katowice, Katowice, Poland.<br /><searchLink fieldCode="AU" term="%22Parenica+J%22">Parenica J</searchLink>; Department of Cardiology, Brno University Hospital, Brno, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Herraiz+Recuenco+L%22">Herraiz Recuenco L</searchLink>; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Huré+G%22">Huré G</searchLink>; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Wildi+K%22">Wildi K</searchLink>; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy; Cantonal Hospital Aarau, Department of Intensive Care, Aarau, Switzerland.<br /><searchLink fieldCode="AU" term="%22Crisanti+L%22">Crisanti L</searchLink>; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Spagnuolo+C%22">Spagnuolo C</searchLink>; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Glaeser+J%22">Glaeser J</searchLink>; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Caubergh+C%22">Caubergh C</searchLink>; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rentsch+K%22">Rentsch K</searchLink>; Laboratory Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Slankamenac+K%22">Slankamenac K</searchLink>; Emergency Department, University Hospital Zurich, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rodriguez+Cetina+Biefer+H%22">Rodriguez Cetina Biefer H</searchLink>; Department of Cardiac Surgery, University Hospital Zürich, University of Zürich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Dzemali+O%22">Dzemali O</searchLink>; Department of Cardiac Surgery, University Hospital Zürich, University of Zürich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Strebel+I%22">Strebel I</searchLink>; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy.<br /><searchLink fieldCode="AU" term="%22Mahfoud+F%22">Mahfoud F</searchLink>; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mills+NL%22">Mills NL</searchLink>; GREAT Network, Roma, Italy; British Heart Foundation Centre for Cardiovascular Sciences, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Boeddinghaus+J%22">Boeddinghaus J</searchLink>; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy; British Heart Foundation Centre for Cardiovascular Sciences, University of Edinburgh, Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Mueller+C%22">Mueller C</searchLink>; Cardiovascular Research Institute Basel, Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland; GREAT Network, Roma, Italy. Electronic address: Luca.koechlin@usb.ch.
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