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A conserved glycan motif induces broadly reactive functional antibodies against the zoonotic pathogen Streptococcus suis.

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Title: A conserved glycan motif induces broadly reactive functional antibodies against the zoonotic pathogen Streptococcus suis.
Authors: Shi Y; Department of Population Health Sciences, Division Farm Animal Health, Utrecht University, Utrecht, Netherlands.; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands., Widmalm G; Department of Chemistry, Arrhenius Laboratory, Stockholm University, Stockholm, Sweden., Sorieul C; Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands., Roodsant TJ; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands., Rush JS; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA., Korotkova N; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA.; Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY, USA., Vrieling M; Wageningen Bioveterinary Research, Houtribweg 39, Lelystad, Netherlands., Jacobs AAC; MSD Animal Health, Wim de Körverstraat 35, Boxmeer, Netherlands., Spaninks M; Department of Population Health Sciences, Division Farm Animal Health, Utrecht University, Utrecht, Netherlands., Grommen R; MSD Animal Health, Wim de Körverstraat 35, Boxmeer, Netherlands., Domínguez-Medina CC; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands., Schimmel IM; Electron Microscopy Center Amsterdam, Amsterdam UMC location University of Amsterdam, Amsterdam, Netherlands., van der Wel NN; Electron Microscopy Center Amsterdam, Amsterdam UMC location University of Amsterdam, Amsterdam, Netherlands., Kenner CW; Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY, USA., Heiss C; Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA., Azadi P; Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA., Tan L; Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA., Codée JDC; Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands., Stegeman A; Department of Population Health Sciences, Division Farm Animal Health, Utrecht University, Utrecht, Netherlands., Schultsz C; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.; Department of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands., Benedictus L; Department of Population Health Sciences, Division Farm Animal Health, Utrecht University, Utrecht, Netherlands., van Sorge NM; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.; Netherlands Reference Laboratory for Bacterial Meningitis (NRLBM), Amsterdam UMC location AMC, Amsterdam, Netherlands.
Source: Science advances [Sci Adv] 2026 Mar 27; Vol. 12 (13), pp. eadz1854. Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: A conserved glycan motif induces broadly reactive functional antibodies against the zoonotic pathogen Streptococcus suis.
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  Data: <searchLink fieldCode="AU" term="%22Shi+Y%22">Shi Y</searchLink>; Department of Population Health Sciences, Division Farm Animal Health, Utrecht University, Utrecht, Netherlands.; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Widmalm+G%22">Widmalm G</searchLink>; Department of Chemistry, Arrhenius Laboratory, Stockholm University, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Sorieul+C%22">Sorieul C</searchLink>; Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Roodsant+TJ%22">Roodsant TJ</searchLink>; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Rush+JS%22">Rush JS</searchLink>; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Korotkova+N%22">Korotkova N</searchLink>; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA.; Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Vrieling+M%22">Vrieling M</searchLink>; Wageningen Bioveterinary Research, Houtribweg 39, Lelystad, Netherlands.<br /><searchLink fieldCode="AU" term="%22Jacobs+AAC%22">Jacobs AAC</searchLink>; MSD Animal Health, Wim de Körverstraat 35, Boxmeer, Netherlands.<br /><searchLink fieldCode="AU" term="%22Spaninks+M%22">Spaninks M</searchLink>; Department of Population Health Sciences, Division Farm Animal Health, Utrecht University, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Grommen+R%22">Grommen R</searchLink>; MSD Animal Health, Wim de Körverstraat 35, Boxmeer, Netherlands.<br /><searchLink fieldCode="AU" term="%22Domínguez-Medina+CC%22">Domínguez-Medina CC</searchLink>; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Schimmel+IM%22">Schimmel IM</searchLink>; Electron Microscopy Center Amsterdam, Amsterdam UMC location University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Wel+NN%22">van der Wel NN</searchLink>; Electron Microscopy Center Amsterdam, Amsterdam UMC location University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Kenner+CW%22">Kenner CW</searchLink>; Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Heiss+C%22">Heiss C</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.<br /><searchLink fieldCode="AU" term="%22Azadi+P%22">Azadi P</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.<br /><searchLink fieldCode="AU" term="%22Tan+L%22">Tan L</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.<br /><searchLink fieldCode="AU" term="%22Codée+JDC%22">Codée JDC</searchLink>; Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Stegeman+A%22">Stegeman A</searchLink>; Department of Population Health Sciences, Division Farm Animal Health, Utrecht University, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Schultsz+C%22">Schultsz C</searchLink>; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.; Department of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Benedictus+L%22">Benedictus L</searchLink>; Department of Population Health Sciences, Division Farm Animal Health, Utrecht University, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Sorge+NM%22">van Sorge NM</searchLink>; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.; Netherlands Reference Laboratory for Bacterial Meningitis (NRLBM), Amsterdam UMC location AMC, Amsterdam, Netherlands.
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  Data: <searchLink fieldCode="JN" term="%22101653440%22">Science advances</searchLink> [Sci Adv] 2026 Mar 27; Vol. 12 (13), pp. eadz1854. <i>Date of Electronic Publication: </i>2026 Mar 25.
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