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Mapping Genomic Heterogeneity in Pediatric and Adolescent-Young Adult Sarcomas: Insights from the Italian SAR-GEN2016 and SAR-GEN_ITA Prospective Multicenter Trials.

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Title: Mapping Genomic Heterogeneity in Pediatric and Adolescent-Young Adult Sarcomas: Insights from the Italian SAR-GEN2016 and SAR-GEN_ITA Prospective Multicenter Trials.
Authors: Tirtei E; Paediatric Onco-Haematology Department, Regina Margherita Children's Hospital, Turin, Italy.; Department of Public Health and Paediatrics, University of Turin, Turin, Italy., Difilippo V; Italian Institute for Genomic Medicine , c/o IRCCS, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Divincenzo F; Paediatric Onco-Haematology Department, Regina Margherita Children's Hospital, Turin, Italy., Asaftei SD; Paediatric Onco-Haematology Department, Regina Margherita Children's Hospital, Turin, Italy., Ratto N; Orthopaedics Oncology Department, AOU Città della Salute e della Scienza di Torino, Turin, Italy., Piana R; Orthopaedics Oncology Department, AOU Città della Salute e della Scienza di Torino, Turin, Italy., Pellegrino P; Orthopaedics Oncology Department, AOU Città della Salute e della Scienza di Torino, Turin, Italy., Linari A; Pathology Unit, AOU Città della Salute e della Scienza di Torino, Turin, Italy., Papotti M; Pathology Unit, Department of Oncology, University of Turin, Turin, Italy., Mareschi K; Paediatric Onco-Haematology Department, Regina Margherita Children's Hospital, Turin, Italy.; Department of Public Health and Paediatrics, University of Turin, Turin, Italy., Parlato C; Italian Institute for Genomic Medicine , c/o IRCCS, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Guarrera S; Italian Institute for Genomic Medicine , c/o IRCCS, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Minucci S; Italian Institute for Genomic Medicine , c/o IRCCS, Candiolo, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy., Rabusin M; Pediatric Hemato-Oncology, Institute of Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy., Manzitti C; U.O.C. Oncologia, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Prete A; Pediatric Hematology and Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Mercolini F; Pediatric Hematology and Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Luksch R; Paediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Meazza C; Paediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Parafioriti A; Pathology Unit, UOC di Anatomia Patologica ASST Pini-CTO, Milan, Italy., Tamburini A; Department of Paediatric Haematology-Oncology, AOU Meyer IRCCS, Florence, Italy., Coccoli L; Paediatric Onco-Haematology Unit, S. Chiara Hospital, AOUP Pisa, Pisa, Italy., Mura R; Paediatric Onco-Haematology Unit, Azienda Ospedaliera Brotzu, Cagliari, Italy., Zecca M; Paediatric Haematology and Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Palmerini E; Osteoncology, Bone and Soft Tissue Sarcomas and Innovative Therapies Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida., Ibrahim T; Osteoncology, Bone and Soft Tissue Sarcomas and Innovative Therapies Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Peirone S; Italian Institute for Genomic Medicine , c/o IRCCS, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Penolazzi L; Paediatric Onco-Haematology Department, Regina Margherita Children's Hospital, Turin, Italy., De Luna E; Paediatric Onco-Haematology Department, Regina Margherita Children's Hospital, Turin, Italy., Cagnazzo C; Paediatric Onco-Haematology Department, Regina Margherita Children's Hospital, Turin, Italy., Bombaci S; Paediatric Onco-Haematology Department, Regina Margherita Children's Hospital, Turin, Italy., Ferrero I; Paediatric Onco-Haematology Department, Regina Margherita Children's Hospital, Turin, Italy., Niclot AGSB; Paediatric Onco-Haematology Department, Regina Margherita Children's Hospital, Turin, Italy., Proto CF; Paediatric Onco-Haematology Department, Regina Margherita Children's Hospital, Turin, Italy., Spadea M; Paediatric Onco-Haematology Department, Regina Margherita Children's Hospital, Turin, Italy.; Department of Public Health and Paediatrics, University of Turin, Turin, Italy., Quarello P; Paediatric Onco-Haematology Department, Regina Margherita Children's Hospital, Turin, Italy.; Department of Public Health and Paediatrics, University of Turin, Turin, Italy., Marini E; Paediatric Onco-Haematology Department, Regina Margherita Children's Hospital, Turin, Italy., Gizzi K; Italian Institute for Genomic Medicine , c/o IRCCS, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Fenoglio B; Italian Institute for Genomic Medicine , c/o IRCCS, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy., Livellara V; U.O.C. Oncologia, IRCCS Istituto Giannina Gaslini, Genoa, Italy.; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy., Di Gangi A; Health Science Interdisciplinary Center, Sant'Anna School of Advanced Studies, Pisa, Italy.; Section of Genomics and Transcriptomics, Fondazione Pisana per la Scienza ONLUS, Pisa, Italy., Puma N; Paediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Sironi G; Paediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Di Bernardo A; Pathology Unit, UOC di Anatomia Patologica ASST Pini-CTO, Milan, Italy., Cereda M; Italian Institute for Genomic Medicine , c/o IRCCS, Candiolo, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.; IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, Italy., Fagioli F; Paediatric Onco-Haematology Department, Regina Margherita Children's Hospital, Turin, Italy.; Department of Public Health and Paediatrics, University of Turin, Turin, Italy.
Source: Cancer research communications [Cancer Res Commun] 2026 Apr 01; Vol. 6 (4), pp. 857-872.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9918281580506676 Publication Model: Print Cited Medium: Internet ISSN: 2767-9764 (Electronic) Linking ISSN: 27679764 NLM ISO Abbreviation: Cancer Res Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mapping Genomic Heterogeneity in Pediatric and Adolescent-Young Adult Sarcomas: Insights from the Italian SAR-GEN2016 and SAR-GEN_ITA Prospective Multicenter Trials.
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  Data: <searchLink fieldCode="AU" term="%22Tirtei+E%22">Tirtei E</searchLink>; Paediatric Onco-Haematology Department, Regina Margherita Children's Hospital, Turin, Italy.; Department of Public Health and Paediatrics, University of Turin, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Difilippo+V%22">Difilippo V</searchLink>; Italian Institute for Genomic Medicine , c/o IRCCS, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Divincenzo+F%22">Divincenzo F</searchLink>; Paediatric Onco-Haematology Department, Regina Margherita Children's Hospital, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Asaftei+SD%22">Asaftei SD</searchLink>; Paediatric Onco-Haematology Department, Regina Margherita Children's Hospital, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Ratto+N%22">Ratto N</searchLink>; Orthopaedics Oncology Department, AOU Città della Salute e della Scienza di Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Piana+R%22">Piana R</searchLink>; Orthopaedics Oncology Department, AOU Città della Salute e della Scienza di Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Pellegrino+P%22">Pellegrino P</searchLink>; Orthopaedics Oncology Department, AOU Città della Salute e della Scienza di Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Linari+A%22">Linari A</searchLink>; Pathology Unit, AOU Città della Salute e della Scienza di Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Papotti+M%22">Papotti M</searchLink>; Pathology Unit, Department of Oncology, University of Turin, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Mareschi+K%22">Mareschi K</searchLink>; Paediatric Onco-Haematology Department, Regina Margherita Children's Hospital, Turin, Italy.; Department of Public Health and Paediatrics, University of Turin, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Parlato+C%22">Parlato C</searchLink>; Italian Institute for Genomic Medicine , c/o IRCCS, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Guarrera+S%22">Guarrera S</searchLink>; Italian Institute for Genomic Medicine , c/o IRCCS, Candiolo, Italy.; Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.<br /><searchLink fieldCode="AU" term="%22Minucci+S%22">Minucci S</searchLink>; Italian Institute for Genomic Medicine , c/o IRCCS, Candiolo, Italy.; Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Rabusin+M%22">Rabusin M</searchLink>; Pediatric Hemato-Oncology, Institute of Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Manzitti+C%22">Manzitti C</searchLink>; U.O.C. 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