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CDK4/6 inhibition enhances CAR-T cell therapy in solid tumors.

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Title: CDK4/6 inhibition enhances CAR-T cell therapy in solid tumors.
Authors: Lelliott EJ; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: emily.lelliott@petermac.org., Naddaf J; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia., Lu KH; Cancer Biology and Therapeutics Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia., Cummins KD; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia., Ramsbottom KM; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia., Reynolds DS; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia., Taylor M; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia., Ambani K; Cancer Biology and Therapeutics Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia., Munoz I; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia., Jackson S; Cancer Evolution and Metastasis Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia., Li J; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia., Chan CW; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia., Britt KL; Cancer Evolution and Metastasis Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia., Beavis PA; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia., Goel S; Cancer Biology and Therapeutics Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: shom.goel@petermac.org., Oliaro J; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: jane.oliaro@petermac.org.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 Mar 24. Date of Electronic Publication: 2026 Mar 24.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CDK4/6 inhibition enhances CAR-T cell therapy in solid tumors.
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  Data: <searchLink fieldCode="AU" term="%22Lelliott+EJ%22">Lelliott EJ</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: emily.lelliott@petermac.org.<br /><searchLink fieldCode="AU" term="%22Naddaf+J%22">Naddaf J</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Lu+KH%22">Lu KH</searchLink>; Cancer Biology and Therapeutics Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Cummins+KD%22">Cummins KD</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Ramsbottom+KM%22">Ramsbottom KM</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Reynolds+DS%22">Reynolds DS</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Taylor+M%22">Taylor M</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Ambani+K%22">Ambani K</searchLink>; Cancer Biology and Therapeutics Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Munoz+I%22">Munoz I</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Jackson+S%22">Jackson S</searchLink>; Cancer Evolution and Metastasis Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Chan+CW%22">Chan CW</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.<br /><searchLink fieldCode="AU" term="%22Britt+KL%22">Britt KL</searchLink>; Cancer Evolution and Metastasis Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Beavis+PA%22">Beavis PA</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Goel+S%22">Goel S</searchLink>; Cancer Biology and Therapeutics Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: shom.goel@petermac.org.<br /><searchLink fieldCode="AU" term="%22Oliaro+J%22">Oliaro J</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: jane.oliaro@petermac.org.
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