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A novel proteolysis-targeting chimera strategy targeting multiple immune checkpoints containing ITIMs enhances antitumor immunity.

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Title: A novel proteolysis-targeting chimera strategy targeting multiple immune checkpoints containing ITIMs enhances antitumor immunity.
Authors: Qiu YY; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China., Wang ZW; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China., He L; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China., Shi GG; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China., Li ZZ; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China., Ma SX; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China., Yu D; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China., Du HC; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China., Xie F; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China., Zhang C; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China., Zhang YQ; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China., Li M; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China., Li WN; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.
Source: Journal of pharmaceutical analysis [J Pharm Anal] 2026 Mar; Vol. 16 (3), pp. 101511. Date of Electronic Publication: 2025 Dec 11.
Publication Type: Journal Article
Journal Info: Publisher: Xi'an Jiaotong University Country of Publication: China NLM ID: 101579451 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2214-0883 (Electronic) Linking ISSN: 22140883 NLM ISO Abbreviation: J Pharm Anal Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: A novel proteolysis-targeting chimera strategy targeting multiple immune checkpoints containing ITIMs enhances antitumor immunity.
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  Data: <searchLink fieldCode="AU" term="%22Qiu+YY%22">Qiu YY</searchLink>; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Wang+ZW%22">Wang ZW</searchLink>; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22He+L%22">He L</searchLink>; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Shi+GG%22">Shi GG</searchLink>; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Li+ZZ%22">Li ZZ</searchLink>; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Ma+SX%22">Ma SX</searchLink>; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Yu+D%22">Yu D</searchLink>; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Du+HC%22">Du HC</searchLink>; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Xie+F%22">Xie F</searchLink>; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Zhang+YQ%22">Zhang YQ</searchLink>; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Li+WN%22">Li WN</searchLink>; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.
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  Data: <searchLink fieldCode="JN" term="%22101579451%22">Journal of pharmaceutical analysis</searchLink> [J Pharm Anal] 2026 Mar; Vol. 16 (3), pp. 101511. <i>Date of Electronic Publication: </i>2025 Dec 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Xi'an+Jiaotong+University%22">Xi'an Jiaotong University </searchLink><i>Country of Publication: </i>China <i>NLM ID: </i>101579451 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2214-0883 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222140883%22">22140883 </searchLink><i>NLM ISO Abbreviation: </i>J Pharm Anal <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1016/j.jpha.2025.101511
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              Text: 2026 Mar
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