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Epigenome-Wide Association Study in Asian Cohort Identifies Novel DNA Methylation Markers for Carotid Intima-Media Thickness.

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Title: Epigenome-Wide Association Study in Asian Cohort Identifies Novel DNA Methylation Markers for Carotid Intima-Media Thickness.
Authors: Tan K; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore., Harris SE; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh Edinburgh, United Kingdom., Maddock J; Division of Surgery and Interventional Science, University College London London, United Kingdom., Tay D; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore., Jain PR; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore., Mok SQ; Laboratory of Complex Disease Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Herbrard M; NPM-Genomic Intelligence & Informatics Engine (NPM-GINIE), Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Schminke U; Department of Neurology, University Medicine Greifswald, Greifswald, Germany., Xue CC; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Goh LL; Personalised Medicine Service, Tan Tock Seng Hospital, Singapore, Singapore., Mina TH; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore., Teumer A; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Lim WK; SingHealth Duke-NUS Institute of Precision Medicine, Singapore, 169609, Singapore.; SingHealth Duke-NUS Genomic Medicine Centre, Singapore, 168582, Singapore.; Cancer & Stem Cell Biology Program, Duke-NUS Medical School, Singapore, 169857, Singapore.; Laboratory of Genome Variation Analytics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore., Leong KP; Personalised Medicine Service, Tan Tock Seng Hospital, Singapore, Singapore., Yeo KK; SingHealth Duke-NUS Institute of Precision Medicine, Singapore, 169609, Singapore.; Department of Cardiology, National Heart Centre Singapore, Singapore, 169609, Singapore.; Duke-NUS Medical School, Singapore, 169857, Singapore., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Center for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, 117549, Singapore., Sing LE; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore., Wardlaw JM; Centre for Clinical Brain Sciences, UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Völzke H; Institute for Community Medicine, University Medicine Greifswald Greifswald, Germany., Wong A; Unit for Lifelong Health and Ageing, MRC National Survey of Health and Development, University College London London, United Kingdom., Cox SR; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh Edinburgh, United Kingdom., Dalan R; Senior Consultant, Department of Endocrinology, Tan Tock Seng Hospital, National Healthcare Group, Singapore, Singapore.; Associate Professor & Co-Director Metabolism, Nutrition and Health, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Dehghan A; School of Public Health, Faculty of Medicine, Imperial College London, United Kingdom.; MRC Centre for Environment and Health, Imperial College London, United Kingdom.; Dementia Research Institute, Imperial College London London, United Kingdom., Loh M; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore.
Corporate Authors: HELIOS Study Team
Source: Research square [Res Sq] 2026 Mar 16. Date of Electronic Publication: 2026 Mar 16.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Tan+K%22">Tan K</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Harris+SE%22">Harris SE</searchLink>; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Maddock+J%22">Maddock J</searchLink>; Division of Surgery and Interventional Science, University College London London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tay+D%22">Tay D</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Jain+PR%22">Jain PR</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Mok+SQ%22">Mok SQ</searchLink>; Laboratory of Complex Disease Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Herbrard+M%22">Herbrard M</searchLink>; NPM-Genomic Intelligence & Informatics Engine (NPM-GINIE), Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Schminke+U%22">Schminke U</searchLink>; Department of Neurology, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Xue+CC%22">Xue CC</searchLink>; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.<br /><searchLink fieldCode="AU" term="%22Goh+LL%22">Goh LL</searchLink>; Personalised Medicine Service, Tan Tock Seng Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Mina+TH%22">Mina TH</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Teumer+A%22">Teumer A</searchLink>; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Lim+WK%22">Lim WK</searchLink>; SingHealth Duke-NUS Institute of Precision Medicine, Singapore, 169609, Singapore.; SingHealth Duke-NUS Genomic Medicine Centre, Singapore, 168582, Singapore.; Cancer & Stem Cell Biology Program, Duke-NUS Medical School, Singapore, 169857, Singapore.; Laboratory of Genome Variation Analytics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore.<br /><searchLink fieldCode="AU" term="%22Leong+KP%22">Leong KP</searchLink>; Personalised Medicine Service, Tan Tock Seng Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Yeo+KK%22">Yeo KK</searchLink>; SingHealth Duke-NUS Institute of Precision Medicine, Singapore, 169609, Singapore.; Department of Cardiology, National Heart Centre Singapore, Singapore, 169609, Singapore.; Duke-NUS Medical School, Singapore, 169857, Singapore.<br /><searchLink fieldCode="AU" term="%22Cheng+CY%22">Cheng CY</searchLink>; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Center for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Sim+X%22">Sim X</searchLink>; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, 117549, Singapore.<br /><searchLink fieldCode="AU" term="%22Sing+LE%22">Sing LE</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Wardlaw+JM%22">Wardlaw JM</searchLink>; Centre for Clinical Brain Sciences, UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Völzke+H%22">Völzke H</searchLink>; Institute for Community Medicine, University Medicine Greifswald Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Wong+A%22">Wong A</searchLink>; Unit for Lifelong Health and Ageing, MRC National Survey of Health and Development, University College London London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cox+SR%22">Cox SR</searchLink>; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh Edinburgh, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Dalan+R%22">Dalan R</searchLink>; Senior Consultant, Department of Endocrinology, Tan Tock Seng Hospital, National Healthcare Group, Singapore, Singapore.; Associate Professor & Co-Director Metabolism, Nutrition and Health, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Dehghan+A%22">Dehghan A</searchLink>; School of Public Health, Faculty of Medicine, Imperial College London, United Kingdom.; MRC Centre for Environment and Health, Imperial College London, United Kingdom.; Dementia Research Institute, Imperial College London London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Loh+M%22">Loh M</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore.
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