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Genome-wide association meta-analyses over one million individuals identify 54 loci associated with urinary incontinence and its subtypes.

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Title: Genome-wide association meta-analyses over one million individuals identify 54 loci associated with urinary incontinence and its subtypes.
Authors: Moreno E; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Arora N; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Bertucci-Richter E; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48103, USA., Eghtedarian R; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland., Andries A; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Thomas LF; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; BioCore - Bioinformatics Core Facility, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Laboratory Medicine, St.Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Horn J; HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Obstetrics and Gynecology, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Stafne SN; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Rehabilitation, St.Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Pathak S; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., FinnGen; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48103, USA.; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; BioCore - Bioinformatics Core Facility, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Laboratory Medicine, St.Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Obstetrics and Gynecology, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.; Clinic of Rehabilitation, St.Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.; Nordlandet legesenter, Kristiansund, Norway.; Broad Institute of Harvard and MIT; Cambridge, MA, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital; Boston, MA, USA.; Centre for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School; Boston, MA, USA.; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, Australia.; MRC Integrative Epidemiology Unit at the University of Bristol, UK.; University of Queensland Frazer Institute, University of Queensland, Woolloongabba, Australia.; Department of Urology, University of Michigan, Ann Arbor, Michigan.; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, US.; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim 7030, Norway., Patil S; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48103, USA., Gulla D; Nordlandet legesenter, Kristiansund, Norway., Ollila HM; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.; Broad Institute of Harvard and MIT; Cambridge, MA, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital; Boston, MA, USA.; Centre for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School; Boston, MA, USA., Evans DM; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, Australia.; MRC Integrative Epidemiology Unit at the University of Bristol, UK.; University of Queensland Frazer Institute, University of Queensland, Woolloongabba, Australia., Ippolito GM; Department of Urology, University of Michigan, Ann Arbor, Michigan., Zhou W; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Coward E; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Hveem K; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway., Surakka I; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, US., Moksnes MR; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Wolford BN; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Brumpton BM; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim 7030, Norway.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Mar 20. Date of Electronic Publication: 2026 Mar 20.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Genome-wide association meta-analyses over one million individuals identify 54 loci associated with urinary incontinence and its subtypes.
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  Data: <searchLink fieldCode="AU" term="%22Moreno+E%22">Moreno E</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Arora+N%22">Arora N</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Bertucci-Richter+E%22">Bertucci-Richter E</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48103, USA.<br /><searchLink fieldCode="AU" term="%22Eghtedarian+R%22">Eghtedarian R</searchLink>; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Andries+A%22">Andries A</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Thomas+LF%22">Thomas LF</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; BioCore - Bioinformatics Core Facility, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Laboratory Medicine, St.Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Horn+J%22">Horn J</searchLink>; HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Obstetrics and Gynecology, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.<br /><searchLink fieldCode="AU" term="%22Stafne+SN%22">Stafne SN</searchLink>; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Rehabilitation, St.Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Pathak+S%22">Pathak S</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22FinnGen%22">FinnGen</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48103, USA.; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.; 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MRC Integrative Epidemiology Unit at the University of Bristol, UK.; University of Queensland Frazer Institute, University of Queensland, Woolloongabba, Australia.; Department of Urology, University of Michigan, Ann Arbor, Michigan.; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, US.; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim 7030, Norway.<br /><searchLink fieldCode="AU" term="%22Patil+S%22">Patil S</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48103, USA.<br /><searchLink fieldCode="AU" term="%22Gulla+D%22">Gulla D</searchLink>; Nordlandet legesenter, Kristiansund, Norway.<br /><searchLink fieldCode="AU" term="%22Ollila+HM%22">Ollila HM</searchLink>; Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.; Broad Institute of Harvard and MIT; Cambridge, MA, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital; Boston, MA, USA.; Centre for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School; Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Evans+DM%22">Evans DM</searchLink>; Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, Australia.; MRC Integrative Epidemiology Unit at the University of Bristol, UK.; University of Queensland Frazer Institute, University of Queensland, Woolloongabba, Australia.<br /><searchLink fieldCode="AU" term="%22Ippolito+GM%22">Ippolito GM</searchLink>; Department of Urology, University of Michigan, Ann Arbor, Michigan.<br /><searchLink fieldCode="AU" term="%22Zhou+W%22">Zhou W</searchLink>; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Coward+E%22">Coward E</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Hveem+K%22">Hveem K</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.<br /><searchLink fieldCode="AU" term="%22Surakka+I%22">Surakka I</searchLink>; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, US.<br /><searchLink fieldCode="AU" term="%22Moksnes+MR%22">Moksnes MR</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.<br /><searchLink fieldCode="AU" term="%22Wolford+BN%22">Wolford BN</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Brumpton+BM%22">Brumpton BM</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim 7030, Norway.
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