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Cell Painting for cytotoxicity and mode-of-action analysis in primary human hepatocytes.

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Title: Cell Painting for cytotoxicity and mode-of-action analysis in primary human hepatocytes.
Authors: Ewald JD; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA; European Bioinformatics Institute, European Molecular Biology Laboratory, Hinxton, UK. Electronic address: jewald@ebi.ac.uk., Titterton KL; Axiom Bio, San Francisco, CA, USA., Bäuerle A; Axiom Bio, San Francisco, CA, USA., Beatson A; Axiom Bio, San Francisco, CA, USA., Boiko DA; Axiom Bio, San Francisco, CA, USA., Cabrera ÁA; Axiom Bio, San Francisco, CA, USA., Cheah J; The Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cimini BA; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Gorissen BL; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Harrill J; Center for Computational Toxicology and Exposure, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC, USA., Jones TR; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Karczewski KJ; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Crute CE; Health and Environmental Sciences Institute, Washington, DC, USA., Rouquie D; Toxicology Data Science, Bayer SAS Crop Science Division, Sophia-Antipolis, Valbonne, France., Seal S; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Weisbart E; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., White B; Axiom Bio, San Francisco, CA, USA., Carpenter AE; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Singh S; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Source: Cell systems [Cell Syst] 2026 May 20; Vol. 17 (5), pp. 101566. Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101656080 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2405-4720 (Electronic) Linking ISSN: 24054712 NLM ISO Abbreviation: Cell Syst Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cell Painting for cytotoxicity and mode-of-action analysis in primary human hepatocytes.
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  Data: <searchLink fieldCode="AU" term="%22Ewald+JD%22">Ewald JD</searchLink>; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA; European Bioinformatics Institute, European Molecular Biology Laboratory, Hinxton, UK. Electronic address: jewald@ebi.ac.uk.<br /><searchLink fieldCode="AU" term="%22Titterton+KL%22">Titterton KL</searchLink>; Axiom Bio, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bäuerle+A%22">Bäuerle A</searchLink>; Axiom Bio, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Beatson+A%22">Beatson A</searchLink>; Axiom Bio, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Boiko+DA%22">Boiko DA</searchLink>; Axiom Bio, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cabrera+ÁA%22">Cabrera ÁA</searchLink>; Axiom Bio, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cheah+J%22">Cheah J</searchLink>; The Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cimini+BA%22">Cimini BA</searchLink>; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gorissen+BL%22">Gorissen BL</searchLink>; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Harrill+J%22">Harrill J</searchLink>; Center for Computational Toxicology and Exposure, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC, USA.<br /><searchLink fieldCode="AU" term="%22Jones+TR%22">Jones TR</searchLink>; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Karczewski+KJ%22">Karczewski KJ</searchLink>; The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Crute+CE%22">Crute CE</searchLink>; Health and Environmental Sciences Institute, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Rouquie+D%22">Rouquie D</searchLink>; Toxicology Data Science, Bayer SAS Crop Science Division, Sophia-Antipolis, Valbonne, France.<br /><searchLink fieldCode="AU" term="%22Seal+S%22">Seal S</searchLink>; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Weisbart+E%22">Weisbart E</searchLink>; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22White+B%22">White B</searchLink>; Axiom Bio, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Carpenter+AE%22">Carpenter AE</searchLink>; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Singh+S%22">Singh S</searchLink>; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
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  Data: <searchLink fieldCode="JN" term="%22101656080%22">Cell systems</searchLink> [Cell Syst] 2026 May 20; Vol. 17 (5), pp. 101566. <i>Date of Electronic Publication: </i>2026 Mar 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101656080 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2405-4720 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2224054712%22">24054712 </searchLink><i>NLM ISO Abbreviation: </i>Cell Syst <i>Subsets: </i>MEDLINE
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              Text: 2026 May 20
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