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Generation of marmoset monkeys with a non-mosaic disruption of the OTOF gene as a model of human deafness.

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Title: Generation of marmoset monkeys with a non-mosaic disruption of the OTOF gene as a model of human deafness.
Authors: Kahland T; Platform Stem Cell Biology and Regeneration, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany., Lindenwald DL; Platform Stem Cell Biology and Regeneration, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany., Jeschke M; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.; Cognitive Hearing in Primates group, Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, Göttingen, Germany.; Else Kröner Fresenius Center for Optogenetic Therapies, University Medical Center, Göttingen, Germany.; Collaborative Research Center CRC 1690 'Disease Mechanisms and Functional Restoration of Sensory and Motor Systems', University of Göttingen, Göttingen, Germany., Kusch K; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.; Else Kröner Fresenius Center for Optogenetic Therapies, University Medical Center, Göttingen, Germany.; Collaborative Research Center CRC 1690 'Disease Mechanisms and Functional Restoration of Sensory and Motor Systems', University of Göttingen, Göttingen, Germany.; Functional Auditory Genomics group, Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, Göttingen, Germany., Tkachenko Eikel O; Platform Stem Cell Biology and Regeneration, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany., Uhl M; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.; Cognitive Hearing in Primates group, Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, Göttingen, Germany.; Collaborative Research Center CRC 1690 'Disease Mechanisms and Functional Restoration of Sensory and Motor Systems', University of Göttingen, Göttingen, Germany.; Functional Auditory Genomics group, Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, Göttingen, Germany., Rüger N; Platform Stem Cell Biology and Regeneration, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany., Drummer C; Platform Stem Cell Biology and Regeneration, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany., Wolf B; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.; Functional Auditory Genomics group, Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany., Benseler F; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany., Brose N; Else Kröner Fresenius Center for Optogenetic Therapies, University Medical Center, Göttingen, Germany.; Collaborative Research Center CRC 1690 'Disease Mechanisms and Functional Restoration of Sensory and Motor Systems', University of Göttingen, Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany.; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany., Behr R; Platform Stem Cell Biology and Regeneration, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany. RBehr@dpz.eu.; Else Kröner Fresenius Center for Optogenetic Therapies, University Medical Center, Göttingen, Germany. RBehr@dpz.eu.; Collaborative Research Center CRC 1690 'Disease Mechanisms and Functional Restoration of Sensory and Motor Systems', University of Göttingen, Göttingen, Germany. RBehr@dpz.eu., Moser T; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany. tmoser@gwdg.de.; Else Kröner Fresenius Center for Optogenetic Therapies, University Medical Center, Göttingen, Germany. tmoser@gwdg.de.; Collaborative Research Center CRC 1690 'Disease Mechanisms and Functional Restoration of Sensory and Motor Systems', University of Göttingen, Göttingen, Germany. tmoser@gwdg.de.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany. tmoser@gwdg.de.; Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, Göttingen, Germany. tmoser@gwdg.de.; Auditory Neuroscience and Synaptic Nanophysiology Group, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany. tmoser@gwdg.de.
Source: Nature communications [Nat Commun] 2026 Mar 28; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Generation of marmoset monkeys with a non-mosaic disruption of the OTOF gene as a model of human deafness.
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  Data: <searchLink fieldCode="AU" term="%22Kahland+T%22">Kahland T</searchLink>; Platform Stem Cell Biology and Regeneration, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Lindenwald+DL%22">Lindenwald DL</searchLink>; Platform Stem Cell Biology and Regeneration, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Jeschke+M%22">Jeschke M</searchLink>; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.; Cognitive Hearing in Primates group, Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, Göttingen, Germany.; Else Kröner Fresenius Center for Optogenetic Therapies, University Medical Center, Göttingen, Germany.; Collaborative Research Center CRC 1690 'Disease Mechanisms and Functional Restoration of Sensory and Motor Systems', University of Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Kusch+K%22">Kusch K</searchLink>; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.; Else Kröner Fresenius Center for Optogenetic Therapies, University Medical Center, Göttingen, Germany.; Collaborative Research Center CRC 1690 'Disease Mechanisms and Functional Restoration of Sensory and Motor Systems', University of Göttingen, Göttingen, Germany.; Functional Auditory Genomics group, Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Tkachenko+Eikel+O%22">Tkachenko Eikel O</searchLink>; Platform Stem Cell Biology and Regeneration, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Uhl+M%22">Uhl M</searchLink>; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.; Cognitive Hearing in Primates group, Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, Göttingen, Germany.; Collaborative Research Center CRC 1690 'Disease Mechanisms and Functional Restoration of Sensory and Motor Systems', University of Göttingen, Göttingen, Germany.; Functional Auditory Genomics group, Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Rüger+N%22">Rüger N</searchLink>; Platform Stem Cell Biology and Regeneration, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Drummer+C%22">Drummer C</searchLink>; Platform Stem Cell Biology and Regeneration, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Wolf+B%22">Wolf B</searchLink>; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany.; Functional Auditory Genomics group, Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Benseler+F%22">Benseler F</searchLink>; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Brose+N%22">Brose N</searchLink>; Else Kröner Fresenius Center for Optogenetic Therapies, University Medical Center, Göttingen, Germany.; Collaborative Research Center CRC 1690 'Disease Mechanisms and Functional Restoration of Sensory and Motor Systems', University of Göttingen, Göttingen, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany.; Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Behr+R%22">Behr R</searchLink>; Platform Stem Cell Biology and Regeneration, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany. RBehr@dpz.eu.; Else Kröner Fresenius Center for Optogenetic Therapies, University Medical Center, Göttingen, Germany. RBehr@dpz.eu.; Collaborative Research Center CRC 1690 'Disease Mechanisms and Functional Restoration of Sensory and Motor Systems', University of Göttingen, Göttingen, Germany. RBehr@dpz.eu.<br /><searchLink fieldCode="AU" term="%22Moser+T%22">Moser T</searchLink>; Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany. tmoser@gwdg.de.; Else Kröner Fresenius Center for Optogenetic Therapies, University Medical Center, Göttingen, Germany. tmoser@gwdg.de.; Collaborative Research Center CRC 1690 'Disease Mechanisms and Functional Restoration of Sensory and Motor Systems', University of Göttingen, Göttingen, Germany. tmoser@gwdg.de.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Göttingen, Germany. tmoser@gwdg.de.; Auditory Neuroscience and Optogenetics Laboratory, German Primate Center, Göttingen, Germany. tmoser@gwdg.de.; Auditory Neuroscience and Synaptic Nanophysiology Group, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany. tmoser@gwdg.de.
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