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Lithium ameliorates neural differentiation restoring cell death balance in Cornelia de Lange syndrome 2D and 3D models.

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Title: Lithium ameliorates neural differentiation restoring cell death balance in Cornelia de Lange syndrome 2D and 3D models.
Authors: Parodi C; Department of Health Sciences, Università degli Studi di Milano, Milan, Italy., Lettieri A; Department of Health Sciences, Università degli Studi di Milano, Milan, Italy., Grazioli P; Department of Health Sciences, Università degli Studi di Milano, Milan, Italy., Di Fede E; Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.; 'Aldo Ravelli' Center for Neurotechnology and Experimental Brain Therapeutics, Università degli Studi di Milano, Milan, Italy., Grassi S; Department of Medical Biotechnology and Translational Medicine, University of Milano, Segrate, Milano, Italy., Taci E; Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.; 'Aldo Ravelli' Center for Neurotechnology and Experimental Brain Therapeutics, Università degli Studi di Milano, Milan, Italy., Toscani A; Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.; 'Aldo Ravelli' Center for Neurotechnology and Experimental Brain Therapeutics, Università degli Studi di Milano, Milan, Italy., Prioni S; Department of Medical Biotechnology and Translational Medicine, University of Milano, Segrate, Milano, Italy., Rebellato S; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Colombo EA; Department of Health Sciences, Università degli Studi di Milano, Milan, Italy., Rasetti S; Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.; 'Aldo Ravelli' Center for Neurotechnology and Experimental Brain Therapeutics, Università degli Studi di Milano, Milan, Italy., Cutarelli A; Dipartimento di Biologia Cellulare, Computazionale e Integrata - CIBIO, Trento, Italy., Mariani M; U.O. di Pediatria dell'ASST Lariana, Como, Italy., Corti S; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy., Finelli P; SS Medical Genetics Laboratory, SC Clinical Pathology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Prinetti A; Department of Medical Biotechnology and Translational Medicine, University of Milano, Segrate, Milano, Italy., Fazio G; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; School of Medicine and Surgery, University of Milano-Bicocca, 20900, Monza, Italy., Selicorni A; U.O. di Pediatria dell'ASST Lariana, Como, Italy., Conti L; Dipartimento di Biologia Cellulare, Computazionale e Integrata - CIBIO, Trento, Italy., Gervasini C; Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.; 'Aldo Ravelli' Center for Neurotechnology and Experimental Brain Therapeutics, Università degli Studi di Milano, Milan, Italy., Massa V; Department of Health Sciences, Università degli Studi di Milano, Milan, Italy. valentina.massa@unimi.it.; 'Aldo Ravelli' Center for Neurotechnology and Experimental Brain Therapeutics, Università degli Studi di Milano, Milan, Italy. valentina.massa@unimi.it.
Source: Cell death discovery [Cell Death Discov] 2026 Mar 28; Vol. 12 (1). Date of Electronic Publication: 2026 Mar 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Lithium ameliorates neural differentiation restoring cell death balance in Cornelia de Lange syndrome 2D and 3D models.
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  Data: <searchLink fieldCode="AU" term="%22Parodi+C%22">Parodi C</searchLink>; Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Lettieri+A%22">Lettieri A</searchLink>; Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Grazioli+P%22">Grazioli P</searchLink>; Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Fede+E%22">Di Fede E</searchLink>; Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.; 'Aldo Ravelli' Center for Neurotechnology and Experimental Brain Therapeutics, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Grassi+S%22">Grassi S</searchLink>; Department of Medical Biotechnology and Translational Medicine, University of Milano, Segrate, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Taci+E%22">Taci E</searchLink>; Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.; 'Aldo Ravelli' Center for Neurotechnology and Experimental Brain Therapeutics, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Toscani+A%22">Toscani A</searchLink>; Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.; 'Aldo Ravelli' Center for Neurotechnology and Experimental Brain Therapeutics, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Prioni+S%22">Prioni S</searchLink>; Department of Medical Biotechnology and Translational Medicine, University of Milano, Segrate, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Rebellato+S%22">Rebellato S</searchLink>; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Colombo+EA%22">Colombo EA</searchLink>; Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Rasetti+S%22">Rasetti S</searchLink>; Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.; 'Aldo Ravelli' Center for Neurotechnology and Experimental Brain Therapeutics, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Cutarelli+A%22">Cutarelli A</searchLink>; Dipartimento di Biologia Cellulare, Computazionale e Integrata - CIBIO, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Mariani+M%22">Mariani M</searchLink>; U.O. di Pediatria dell'ASST Lariana, Como, Italy.<br /><searchLink fieldCode="AU" term="%22Corti+S%22">Corti S</searchLink>; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Finelli+P%22">Finelli P</searchLink>; SS Medical Genetics Laboratory, SC Clinical Pathology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Prinetti+A%22">Prinetti A</searchLink>; Department of Medical Biotechnology and Translational Medicine, University of Milano, Segrate, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Fazio+G%22">Fazio G</searchLink>; Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; School of Medicine and Surgery, University of Milano-Bicocca, 20900, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Selicorni+A%22">Selicorni A</searchLink>; U.O. di Pediatria dell'ASST Lariana, Como, Italy.<br /><searchLink fieldCode="AU" term="%22Conti+L%22">Conti L</searchLink>; Dipartimento di Biologia Cellulare, Computazionale e Integrata - CIBIO, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Gervasini+C%22">Gervasini C</searchLink>; Department of Health Sciences, Università degli Studi di Milano, Milan, Italy.; 'Aldo Ravelli' Center for Neurotechnology and Experimental Brain Therapeutics, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Massa+V%22">Massa V</searchLink>; Department of Health Sciences, Università degli Studi di Milano, Milan, Italy. valentina.massa@unimi.it.; 'Aldo Ravelli' Center for Neurotechnology and Experimental Brain Therapeutics, Università degli Studi di Milano, Milan, Italy. valentina.massa@unimi.it.
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  Data: <searchLink fieldCode="JN" term="%22101665035%22">Cell death discovery</searchLink> [Cell Death Discov] 2026 Mar 28; Vol. 12 (1). <i>Date of Electronic Publication: </i>2026 Mar 28.
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