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Early Vigabatrin Treatment Before Seizure Onset Decreased Interictal Epileptiform Discharges Over the Duration of the PREVeNT Study.

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Title: Early Vigabatrin Treatment Before Seizure Onset Decreased Interictal Epileptiform Discharges Over the Duration of the PREVeNT Study.
Authors: McPherson TO; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia., Bebin EM; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama., Farach LS; Department of Pediatrics, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth Houston) and Children's Memorial Hermann Hospital, Houston, Texas., Wulsin AC; Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Davis P; Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Au KS; Division of Medical Genetics, Department of Pediatrics, McGovern Medical School at UTHealth Houston, Houston, Texas., Sahin M; Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Wu JY; Division of Pediatric Neurology, Department of Pediatrics, David Geffen School of Medicine, UCLA Mattel Children's Hospital, Los Angeles, California., Taub KS; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Rajaraman R; Department of Pediatrics and Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California., Randle S; Seattle Children's Hospital, Seattle, Washington., McClintock WM; Department of Neurology, Children's National Hospital, Washington, District of Columbia., Koenig MK; Division of Child Neurology, Department of Pediatrics, McGovern Medical School at UTHealth Houston, Houston, Texas., Frost MD; Minnesota Epilepsy Group, Roseville, Minnesota., Northrup H; Division of Medical Genetics, Department of Pediatrics, McGovern Medical School at UTHealth Houston, Houston, Texas., Werner K; Department of Pediatrics, Duke University, Durham, North Carolina., Nolan D; Beaumont Florence and Richard McBrien Pediatric Neuroscience Center, Beaumont Hospital, Royal Oak, Michigan., Wong M; Department of Neurology, Washington University in Saint Louis, Saint Louis, Missouri., Krefting J; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama., Peri K; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama., Cutter G; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama., Krueger D; Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio., Peters JM; Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Porter BE; Department of Neurology, Stanford University, Stanford, California.
Corporate Authors: PREVeNT Study Group
Source: Pediatric neurology [Pediatr Neurol] 2026 Jun; Vol. 179, pp. 30-36. Date of Electronic Publication: 2026 Mar 11.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Elsevier Science Publishing Country of Publication: United States NLM ID: 8508183 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5150 (Electronic) Linking ISSN: 08878994 NLM ISO Abbreviation: Pediatr Neurol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22McPherson+TO%22">McPherson TO</searchLink>; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Bebin+EM%22">Bebin EM</searchLink>; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama.<br /><searchLink fieldCode="AU" term="%22Farach+LS%22">Farach LS</searchLink>; Department of Pediatrics, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth Houston) and Children's Memorial Hermann Hospital, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Wulsin+AC%22">Wulsin AC</searchLink>; Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Davis+P%22">Davis P</searchLink>; Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Au+KS%22">Au KS</searchLink>; Division of Medical Genetics, Department of Pediatrics, McGovern Medical School at UTHealth Houston, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Sahin+M%22">Sahin M</searchLink>; Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Wu+JY%22">Wu JY</searchLink>; Division of Pediatric Neurology, Department of Pediatrics, David Geffen School of Medicine, UCLA Mattel Children's Hospital, Los Angeles, California.<br /><searchLink fieldCode="AU" term="%22Taub+KS%22">Taub KS</searchLink>; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Rajaraman+R%22">Rajaraman R</searchLink>; Department of Pediatrics and Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California.<br /><searchLink fieldCode="AU" term="%22Randle+S%22">Randle S</searchLink>; Seattle Children's Hospital, Seattle, Washington.<br /><searchLink fieldCode="AU" term="%22McClintock+WM%22">McClintock WM</searchLink>; Department of Neurology, Children's National Hospital, Washington, District of Columbia.<br /><searchLink fieldCode="AU" term="%22Koenig+MK%22">Koenig MK</searchLink>; Division of Child Neurology, Department of Pediatrics, McGovern Medical School at UTHealth Houston, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Frost+MD%22">Frost MD</searchLink>; Minnesota Epilepsy Group, Roseville, Minnesota.<br /><searchLink fieldCode="AU" term="%22Northrup+H%22">Northrup H</searchLink>; Division of Medical Genetics, Department of Pediatrics, McGovern Medical School at UTHealth Houston, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Werner+K%22">Werner K</searchLink>; Department of Pediatrics, Duke University, Durham, North Carolina.<br /><searchLink fieldCode="AU" term="%22Nolan+D%22">Nolan D</searchLink>; Beaumont Florence and Richard McBrien Pediatric Neuroscience Center, Beaumont Hospital, Royal Oak, Michigan.<br /><searchLink fieldCode="AU" term="%22Wong+M%22">Wong M</searchLink>; Department of Neurology, Washington University in Saint Louis, Saint Louis, Missouri.<br /><searchLink fieldCode="AU" term="%22Krefting+J%22">Krefting J</searchLink>; Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama.<br /><searchLink fieldCode="AU" term="%22Peri+K%22">Peri K</searchLink>; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama.<br /><searchLink fieldCode="AU" term="%22Cutter+G%22">Cutter G</searchLink>; Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama.<br /><searchLink fieldCode="AU" term="%22Krueger+D%22">Krueger D</searchLink>; Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio.<br /><searchLink fieldCode="AU" term="%22Peters+JM%22">Peters JM</searchLink>; Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Porter+BE%22">Porter BE</searchLink>; Department of Neurology, Stanford University, Stanford, California.
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  Data: <searchLink fieldCode="JN" term="%228508183%22">Pediatric neurology</searchLink> [Pediatr Neurol] 2026 Jun; Vol. 179, pp. 30-36. <i>Date of Electronic Publication: </i>2026 Mar 11.
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