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Coixol attenuates osteoclastogenesis and ovariectomy-induced bone loss via the HIF-1α-mediated suppression of NF-κB signaling.

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Title: Coixol attenuates osteoclastogenesis and ovariectomy-induced bone loss via the HIF-1α-mediated suppression of NF-κB signaling.
Authors: Shi SW; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: 6232833045@stu.jiangnan.edu.cn., Fu YF; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: weiderrick93@gmail.com., Wu X; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: wizx@live.cn., Wang LS; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: 6222809140@stu.jiangnan.edu.cn., Zhang ZY; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: zhangzhenyu_jd@163.com., Luo ZX; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: lzx61783018@163.com., Wu JJ; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China. Electronic address: 18119652961@163.com., Yuan ZD; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China. Electronic address: 1045261385@qq.com., Nie H; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China. Electronic address: 13474738602@163.com., Zhang KY; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: kk13269@163.com., Ti HB; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: tihuibo@163.com., Hu HT; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: 18652875652@163.com., Qian YQ; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: InsomniaQ@163.com., Wang XC; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: 2431471638@qq.com., Yao XC; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: yaoxc1999@163.com., Peng T; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: 7253305005@stu.jiangnan.edu.cn., Li X; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: lixia.ahmu.cn@163.com., Yuan FL; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: bjjq88@jiangnan.edu.cn., Ye JX; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: 9862019268@jiangnan.edu.cn.
Source: European journal of pharmacology [Eur J Pharmacol] 2026 Apr 15; Vol. 1021, pp. 178811. Date of Electronic Publication: 2026 Mar 27.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Coixol attenuates osteoclastogenesis and ovariectomy-induced bone loss via the HIF-1α-mediated suppression of NF-κB signaling.
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  Data: <searchLink fieldCode="AU" term="%22Shi+SW%22">Shi SW</searchLink>; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: 6232833045@stu.jiangnan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Fu+YF%22">Fu YF</searchLink>; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: weiderrick93@gmail.com.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: wizx@live.cn.<br /><searchLink fieldCode="AU" term="%22Wang+LS%22">Wang LS</searchLink>; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: 6222809140@stu.jiangnan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+ZY%22">Zhang ZY</searchLink>; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: zhangzhenyu_jd@163.com.<br /><searchLink fieldCode="AU" term="%22Luo+ZX%22">Luo ZX</searchLink>; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: lzx61783018@163.com.<br /><searchLink fieldCode="AU" term="%22Wu+JJ%22">Wu JJ</searchLink>; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China. Electronic address: 18119652961@163.com.<br /><searchLink fieldCode="AU" term="%22Yuan+ZD%22">Yuan ZD</searchLink>; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China. Electronic address: 1045261385@qq.com.<br /><searchLink fieldCode="AU" term="%22Nie+H%22">Nie H</searchLink>; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China. Electronic address: 13474738602@163.com.<br /><searchLink fieldCode="AU" term="%22Zhang+KY%22">Zhang KY</searchLink>; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: kk13269@163.com.<br /><searchLink fieldCode="AU" term="%22Ti+HB%22">Ti HB</searchLink>; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: tihuibo@163.com.<br /><searchLink fieldCode="AU" term="%22Hu+HT%22">Hu HT</searchLink>; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: 18652875652@163.com.<br /><searchLink fieldCode="AU" term="%22Qian+YQ%22">Qian YQ</searchLink>; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: InsomniaQ@163.com.<br /><searchLink fieldCode="AU" term="%22Wang+XC%22">Wang XC</searchLink>; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: 2431471638@qq.com.<br /><searchLink fieldCode="AU" term="%22Yao+XC%22">Yao XC</searchLink>; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: yaoxc1999@163.com.<br /><searchLink fieldCode="AU" term="%22Peng+T%22">Peng T</searchLink>; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: 7253305005@stu.jiangnan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: lixia.ahmu.cn@163.com.<br /><searchLink fieldCode="AU" term="%22Yuan+FL%22">Yuan FL</searchLink>; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: bjjq88@jiangnan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Ye+JX%22">Ye JX</searchLink>; Institute of Integrated Chinese and Western Medicine, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China; Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu, 214122, China. Electronic address: 9862019268@jiangnan.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%221254354%22">European journal of pharmacology</searchLink> [Eur J Pharmacol] 2026 Apr 15; Vol. 1021, pp. 178811. <i>Date of Electronic Publication: </i>2026 Mar 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>1254354 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0712 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200142999%22">00142999 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Pharmacol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.ejphar.2026.178811
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        Text: English
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              Text: 2026 Apr 15
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