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Peptide-based Wnt signal activation enables scalable production of clinical-grade patient-derived intestinal organoids for regenerative cell therapy.

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Title: Peptide-based Wnt signal activation enables scalable production of clinical-grade patient-derived intestinal organoids for regenerative cell therapy.
Authors: Sugihara HY; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Nagata S; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Kawasaki S; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Takahashi J; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA., Hiraguri Y; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Fukuda M; Endoscopic Unit, Institute of Science Tokyo Hospital, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Suzuki K; Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA., Murano T; Endoscopic Unit, Institute of Science Tokyo Hospital, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Fujii S; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Fujii T; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Shimizu H; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Ohtsuka K; Endoscopic Unit, Institute of Science Tokyo Hospital, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Watanabe M; Graduate School of Medicine, Juntendo University, 2-1-1, Hongo, Bunkyo- ku, Tokyo, 113-8421, Japan., Okamoto R; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan. rokamoto.gast@tmd.ac.jp., Mizutani T; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan. tmizutani.gast@tmd.ac.jp.
Source: Stem cell research & therapy [Stem Cell Res Ther] 2026 Mar 29; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 29.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Peptide-based Wnt signal activation enables scalable production of clinical-grade patient-derived intestinal organoids for regenerative cell therapy.
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  Data: <searchLink fieldCode="AU" term="%22Sugihara+HY%22">Sugihara HY</searchLink>; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Nagata+S%22">Nagata S</searchLink>; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Kawasaki+S%22">Kawasaki S</searchLink>; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Takahashi+J%22">Takahashi J</searchLink>; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA.<br /><searchLink fieldCode="AU" term="%22Hiraguri+Y%22">Hiraguri Y</searchLink>; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Fukuda+M%22">Fukuda M</searchLink>; Endoscopic Unit, Institute of Science Tokyo Hospital, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+K%22">Suzuki K</searchLink>; Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA.<br /><searchLink fieldCode="AU" term="%22Murano+T%22">Murano T</searchLink>; Endoscopic Unit, Institute of Science Tokyo Hospital, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Fujii+S%22">Fujii S</searchLink>; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Fujii+T%22">Fujii T</searchLink>; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Shimizu+H%22">Shimizu H</searchLink>; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Ohtsuka+K%22">Ohtsuka K</searchLink>; Endoscopic Unit, Institute of Science Tokyo Hospital, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+M%22">Watanabe M</searchLink>; Graduate School of Medicine, Juntendo University, 2-1-1, Hongo, Bunkyo- ku, Tokyo, 113-8421, Japan.<br /><searchLink fieldCode="AU" term="%22Okamoto+R%22">Okamoto R</searchLink>; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan. rokamoto.gast@tmd.ac.jp.<br /><searchLink fieldCode="AU" term="%22Mizutani+T%22">Mizutani T</searchLink>; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan. tmizutani.gast@tmd.ac.jp.
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  Data: <searchLink fieldCode="JN" term="%22101527581%22">Stem cell research & therapy</searchLink> [Stem Cell Res Ther] 2026 Mar 29; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Mar 29.
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              Text: 2026 Mar 29
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