Peptide-based Wnt signal activation enables scalable production of clinical-grade patient-derived intestinal organoids for regenerative cell therapy.
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| Title: | Peptide-based Wnt signal activation enables scalable production of clinical-grade patient-derived intestinal organoids for regenerative cell therapy. |
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| Authors: | Sugihara HY; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Nagata S; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Kawasaki S; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Takahashi J; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229-3026, USA., Hiraguri Y; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Fukuda M; Endoscopic Unit, Institute of Science Tokyo Hospital, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Suzuki K; Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA., Murano T; Endoscopic Unit, Institute of Science Tokyo Hospital, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Fujii S; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Fujii T; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Shimizu H; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Ohtsuka K; Endoscopic Unit, Institute of Science Tokyo Hospital, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Watanabe M; Graduate School of Medicine, Juntendo University, 2-1-1, Hongo, Bunkyo- ku, Tokyo, 113-8421, Japan., Okamoto R; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan. rokamoto.gast@tmd.ac.jp., Mizutani T; Department of Gastroenterology and Hepatology, Institute of Science Tokyo, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan. tmizutani.gast@tmd.ac.jp. |
| Source: | Stem cell research & therapy [Stem Cell Res Ther] 2026 Mar 29; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 29. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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