Modified Jie-Yu-He-Huan Capsule in Post-Stroke Depression Treatment: Insights from DIA Proteomic and PRM Validation.

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Title: Modified Jie-Yu-He-Huan Capsule in Post-Stroke Depression Treatment: Insights from DIA Proteomic and PRM Validation.
Authors: Wang X; Institute for Chinese Medicine and Brain Science, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Provincial Engineering Research Center for the Prevention and Treatment of Major Brain Diseases with Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Experimental Center, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China., Gao Q; Department of Basic Medical Sciences, Shijiazhuang Medical College, Shijiazhuang, Hebei, People's Republic of China., Liu C; Department of Traditional Chinese Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong, People's Republic of China.; First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, People's Republic of China., Hu M; Institute for Chinese Medicine and Brain Science, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China., Liu Z; Institute for Chinese Medicine and Brain Science, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Provincial Engineering Research Center for the Prevention and Treatment of Major Brain Diseases with Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China., Li Z; Institute for Chinese Medicine and Brain Science, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Provincial Engineering Research Center for the Prevention and Treatment of Major Brain Diseases with Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Experimental Center, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China., Zhang H; Institute for Chinese Medicine and Brain Science, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Provincial Engineering Research Center for the Prevention and Treatment of Major Brain Diseases with Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China., Wu L; Institute for Chinese Medicine and Brain Science, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Provincial Engineering Research Center for the Prevention and Treatment of Major Brain Diseases with Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China., Chen K; Shandong Innovation Center of Engineered Bacteriophage Therapeutics, Shandong Academy of Pharmaceutical Sciences, Ji'nan, Shandong, People's Republic of China., Xu K; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Provincial Engineering Research Center for the Prevention and Treatment of Major Brain Diseases with Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Experimental Center, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China., Geng X; Institute for Chinese Medicine and Brain Science, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Provincial Engineering Research Center for the Prevention and Treatment of Major Brain Diseases with Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Experimental Center, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China., Liu W; Institute for Chinese Medicine and Brain Science, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Provincial Engineering Research Center for the Prevention and Treatment of Major Brain Diseases with Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Department of Encephalopathy, The second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, People's Republic of China., Wei S; Institute for Chinese Medicine and Brain Science, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Provincial Engineering Research Center for the Prevention and Treatment of Major Brain Diseases with Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.
Source: Drug design, development and therapy [Drug Des Devel Ther] 2026 Feb 04; Vol. 20, pp. 565281. Date of Electronic Publication: 2026 Feb 04 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE
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  Data: Modified Jie-Yu-He-Huan Capsule in Post-Stroke Depression Treatment: Insights from DIA Proteomic and PRM Validation.
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  Data: <searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Institute for Chinese Medicine and Brain Science, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Provincial Engineering Research Center for the Prevention and Treatment of Major Brain Diseases with Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Experimental Center, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Gao+Q%22">Gao Q</searchLink>; Department of Basic Medical Sciences, Shijiazhuang Medical College, Shijiazhuang, Hebei, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Department of Traditional Chinese Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, Shandong, People's Republic of China.; First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Hu+M%22">Hu M</searchLink>; Institute for Chinese Medicine and Brain Science, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Institute for Chinese Medicine and Brain Science, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Provincial Engineering Research Center for the Prevention and Treatment of Major Brain Diseases with Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Institute for Chinese Medicine and Brain Science, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Provincial Engineering Research Center for the Prevention and Treatment of Major Brain Diseases with Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Experimental Center, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Institute for Chinese Medicine and Brain Science, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Provincial Engineering Research Center for the Prevention and Treatment of Major Brain Diseases with Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Wu+L%22">Wu L</searchLink>; Institute for Chinese Medicine and Brain Science, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Provincial Engineering Research Center for the Prevention and Treatment of Major Brain Diseases with Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; Shandong Innovation Center of Engineered Bacteriophage Therapeutics, Shandong Academy of Pharmaceutical Sciences, Ji'nan, Shandong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Xu+K%22">Xu K</searchLink>; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Provincial Engineering Research Center for the Prevention and Treatment of Major Brain Diseases with Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Experimental Center, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Geng+X%22">Geng X</searchLink>; Institute for Chinese Medicine and Brain Science, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Provincial Engineering Research Center for the Prevention and Treatment of Major Brain Diseases with Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Experimental Center, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Liu+W%22">Liu W</searchLink>; Institute for Chinese Medicine and Brain Science, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Provincial Engineering Research Center for the Prevention and Treatment of Major Brain Diseases with Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Department of Encephalopathy, The second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Wei+S%22">Wei S</searchLink>; Institute for Chinese Medicine and Brain Science, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Key Laboratory of Innovation and Application Research in Basic Theory of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.; Shandong Provincial Engineering Research Center for the Prevention and Treatment of Major Brain Diseases with Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, Shandong, 250355, People's Republic of China.
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