Systemic immune profiling uncovers divergent mechanisms and predictive biomarkers of response to combination immunotherapies in hepatocellular carcinoma.
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| Title: | Systemic immune profiling uncovers divergent mechanisms and predictive biomarkers of response to combination immunotherapies in hepatocellular carcinoma. |
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| Authors: | Nishio A; Department of Gastroenterology and Hepatology, Graduate School of Medicine, The University of Osaka, Suita, Japan.; Department of Gastroenterology and Hepatology, Japan Community Health Care Organization Osaka Hospital, Osaka, Japan., Kodama T; Department of Gastroenterology and Hepatology, Graduate School of Medicine, The University of Osaka, Suita, Japan t-kodama@gh.med.osaka-u.ac.jp., Daiku K; Department of Gastroenterology and Hepatology, Graduate School of Medicine, The University of Osaka, Suita, Japan., Maesaka K; Department of Gastroenterology and Hepatology, Graduate School of Medicine, The University of Osaka, Suita, Japan., Tanaka S; Department of Gastroenterology and Hepatology, National Hospital Organization Osaka National Hospital, Osaka, Japan., Nozaki Y; Department of Gastroenterology and Hepatology, Kansai Rosai Hospital, Amagasaki, Japan., Kurahashi T; Department of Gastroenterology and Hepatology, Osaka Rosai Hospital, Sakai, Japan., Matsumoto K; Department of Gastroenterology and Hepatology, Toyonaka Municipal Hospital, Toyonaka, Japan., Nawa T; Department of Gastroenterology and Hepatology, Higashiosaka City Medical Center, Higashiosaka, Japan., Tawara S; Department of Gastroenterology and Hepatology, Osaka General Medical Center, Osaka, Japan., Tokuda Y; Department of Gastroenterology and Hepatology, Japan Community Health Care Organization Osaka Hospital, Osaka, Japan., Nakabori T; Department of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, Japan., Sakamori R; Department of Gastroenterology and Hepatology, National Hospital Organization Osaka National Hospital, Osaka, Japan., Ohkawa K; Department of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, Japan., Miyazaki M; Department of Gastroenterology and Hepatology, Osaka Keisatsu Hospital, Osaka, Japan., Yamamoto S; Department of Gastroenterology and Hepatology, Graduate School of Medicine, The University of Osaka, Suita, Japan., Shigeno S; Department of Gastroenterology and Hepatology, Graduate School of Medicine, The University of Osaka, Suita, Japan., Myojin Y; Department of Gastroenterology and Hepatology, Graduate School of Medicine, The University of Osaka, Suita, Japan., Tahata Y; Department of Gastroenterology and Hepatology, Graduate School of Medicine, The University of Osaka, Suita, Japan., Hikita H; Department of Gastroenterology and Hepatology, Graduate School of Medicine, The University of Osaka, Suita, Japan., Takehara T; Department of Gastroenterology and Hepatology, Graduate School of Medicine, The University of Osaka, Suita, Japan. |
| Source: | Journal for immunotherapy of cancer [J Immunother Cancer] 2026 Mar 30; Vol. 14 (3). Date of Electronic Publication: 2026 Mar 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41912268 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Systemic immune profiling uncovers divergent mechanisms and predictive biomarkers of response to combination immunotherapies in hepatocellular carcinoma. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Nishio+A%22">Nishio A</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medicine, The University of Osaka, Suita, Japan.; Department of Gastroenterology and Hepatology, Japan Community Health Care Organization Osaka Hospital, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Kodama+T%22">Kodama T</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medicine, The University of Osaka, Suita, Japan t-kodama@gh.med.osaka-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Daiku+K%22">Daiku K</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medicine, The University of Osaka, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Maesaka+K%22">Maesaka K</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medicine, The University of Osaka, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Tanaka+S%22">Tanaka S</searchLink>; Department of Gastroenterology and Hepatology, National Hospital Organization Osaka National Hospital, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Nozaki+Y%22">Nozaki Y</searchLink>; Department of Gastroenterology and Hepatology, Kansai Rosai Hospital, Amagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Kurahashi+T%22">Kurahashi T</searchLink>; Department of Gastroenterology and Hepatology, Osaka Rosai Hospital, Sakai, Japan.<br /><searchLink fieldCode="AU" term="%22Matsumoto+K%22">Matsumoto K</searchLink>; Department of Gastroenterology and Hepatology, Toyonaka Municipal Hospital, Toyonaka, Japan.<br /><searchLink fieldCode="AU" term="%22Nawa+T%22">Nawa T</searchLink>; Department of Gastroenterology and Hepatology, Higashiosaka City Medical Center, Higashiosaka, Japan.<br /><searchLink fieldCode="AU" term="%22Tawara+S%22">Tawara S</searchLink>; Department of Gastroenterology and Hepatology, Osaka General Medical Center, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Tokuda+Y%22">Tokuda Y</searchLink>; Department of Gastroenterology and Hepatology, Japan Community Health Care Organization Osaka Hospital, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Nakabori+T%22">Nakabori T</searchLink>; Department of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Sakamori+R%22">Sakamori R</searchLink>; Department of Gastroenterology and Hepatology, National Hospital Organization Osaka National Hospital, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Ohkawa+K%22">Ohkawa K</searchLink>; Department of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Miyazaki+M%22">Miyazaki M</searchLink>; Department of Gastroenterology and Hepatology, Osaka Keisatsu Hospital, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Yamamoto+S%22">Yamamoto S</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medicine, The University of Osaka, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Shigeno+S%22">Shigeno S</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medicine, The University of Osaka, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Myojin+Y%22">Myojin Y</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medicine, The University of Osaka, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Tahata+Y%22">Tahata Y</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medicine, The University of Osaka, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Hikita+H%22">Hikita H</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medicine, The University of Osaka, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Takehara+T%22">Takehara T</searchLink>; Department of Gastroenterology and Hepatology, Graduate School of Medicine, The University of Osaka, Suita, Japan. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101620585%22">Journal for immunotherapy of cancer</searchLink> [J Immunother Cancer] 2026 Mar 30; Vol. 14 (3). <i>Date of Electronic Publication: </i>2026 Mar 30. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group+Ltd%22">BMJ Publishing Group Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101620585 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-1426 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220511426%22">20511426 </searchLink><i>NLM ISO Abbreviation: </i>J Immunother Cancer <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41912268 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1136/jitc-2025-013648 Languages: – Code: eng Text: English Titles: – TitleFull: Systemic immune profiling uncovers divergent mechanisms and predictive biomarkers of response to combination immunotherapies in hepatocellular carcinoma. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Nishio A – PersonEntity: Name: NameFull: Kodama T – PersonEntity: Name: NameFull: Daiku K – PersonEntity: Name: NameFull: Maesaka K – PersonEntity: Name: NameFull: Tanaka S – PersonEntity: Name: NameFull: Nozaki Y – PersonEntity: Name: NameFull: Kurahashi T – PersonEntity: Name: NameFull: Matsumoto K – PersonEntity: Name: NameFull: Nawa T – PersonEntity: Name: NameFull: Tawara S – PersonEntity: Name: NameFull: Tokuda Y – PersonEntity: Name: NameFull: Nakabori T – PersonEntity: Name: NameFull: Sakamori R – PersonEntity: Name: NameFull: Ohkawa K – PersonEntity: Name: NameFull: Miyazaki M – PersonEntity: Name: NameFull: Yamamoto S – PersonEntity: Name: NameFull: Shigeno S – PersonEntity: Name: NameFull: Myojin Y – PersonEntity: Name: NameFull: Tahata Y – PersonEntity: Name: NameFull: Hikita H – PersonEntity: Name: NameFull: Takehara T IsPartOfRelationships: – BibEntity: Dates: – D: 30 M: 03 Text: 2026 Mar 30 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2051-1426 Numbering: – Type: volume Value: 14 – Type: issue Value: 3 Titles: – TitleFull: Journal for immunotherapy of cancer Type: main |
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