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Deleterious coding variation associated with autism is shared across ancestries.

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Title: Deleterious coding variation associated with autism is shared across ancestries.
Authors: Natividad Avila M; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jung S; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Satterstrom FK; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Fu JM; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Levy T; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sloofman LG; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Klei L; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Pichardo T; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Marquez D; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Stevens CR; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Cusick CM; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ames JL; Division of Research, Kaiser Permanente Northern, Pleasanton, CA, USA., Campos GS; Centro de Estudos do Genoma Humano e Células-Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brasil., Cerros H; Division of Research, Kaiser Permanente Northern, Pleasanton, CA, USA., Chaskel R; Facultad de Medicina, Universidad de los Andes, Bogotá, Colombia.; Instituto Colombiano del Sistema Nervioso, Clínica Montserrat, Bogotá, Colombia., Costa CIS; Centro de Estudos do Genoma Humano e Células-Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brasil., Cuccaro ML; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.; The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA., Lopez ADP; Facultad de Medicina, Universidad de los Andes, Bogotá, Colombia., Fernandez M; Instituto Colombiano del Sistema Nervioso, Clínica Montserrat, Bogotá, Colombia., Ferro E; Instituto Colombiano del Sistema Nervioso, Clínica Montserrat, Bogotá, Colombia., Galeano L; Facultad de Ciencias, Universidad de los Andes, Bogotá, Colombia., Girardi ACDES; Centro de Estudos do Genoma Humano e Células-Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brasil., Griswold AJ; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.; The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA., Hernandez LC; Facultad de Ciencias, Universidad de los Andes, Bogotá, Colombia., Lourenço N; Centro de Estudos do Genoma Humano e Células-Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brasil., Ludena Y; MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California, Davis, Davis, CA, USA., Núñez-Ríos D; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; National Center of Posttraumatic Stress Disorders, VA CT Healthcare Center, West Haven, CT, USA., Oyama R; Centro Ann Sullivan del Peru, Lima, Peru., Peña KP; Facultad de Ciencias, Universidad de los Andes, Bogotá, Colombia., Pessah I; MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California, Davis, Davis, CA, USA., Schmidt R; MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California, Davis, Davis, CA, USA., Sweeney HM; Center Ann Sullivan International, Lawrence, KS, USA., Tolentino L; Centro Ann Sullivan del Peru, Lima, Peru., Wang JYT; Centro de Estudos do Genoma Humano e Células-Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brasil., Albores-Gallo L; Hospital Psiquiátrico Infantil Dr. Juan N. Navarro, Mexico City, Mexico.; Universidad Nacional Autónoma de México, Mexico City, Mexico., Croen LA; Division of Research, Kaiser Permanente Northern, Pleasanton, CA, USA.; Kaiser Permanente School of Medicine, Pasadena, CA, USA., Cruz-Fuentes CS; Departamento de Genética, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz México, Ciudad de México, Mexico., Hertz-Picciotto I; MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California, Davis, Davis, CA, USA., Kolevzon A; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lattig MC; Facultad de Ciencias, Universidad de los Andes, Bogotá, Colombia., Mayo L; Centro Ann Sullivan del Peru, Lima, Peru., Passos-Bueno MR; Centro de Estudos do Genoma Humano e Células-Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brasil., Pericak-Vance MA; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.; The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA., Siper PM; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tassone F; MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California, Davis, Davis, CA, USA.; Department of Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Davis, CA, USA., Trelles MP; Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA, USA., Talkowski ME; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA., Daly MJ; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Mahjani B; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., De Rubeis S; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Alper Center for Neural Development and Regeneration, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cook EH; Department of Psychiatry, University of Illinois Chicago, Chicago, IL, USA., Roeder K; Department of Statistics, Carnegie Mellon University, Pittsburgh, PA, USA.; Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA., Betancur C; Sorbonne Université, INSERM, CNRS, Institut de Biologie Paris Seine, Center for Neuroscience at Sorbonne Université, Paris, France., Devlin B; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Buxbaum JD; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.
Corporate Authors: GALA Consortium, Autism Sequencing Consortium (ASC)
Source: Nature medicine [Nat Med] 2026 Apr; Vol. 32 (4), pp. 1519-1529. Date of Electronic Publication: 2026 Mar 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
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PubTypeId: academicJournal
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  Data: Deleterious coding variation associated with autism is shared across ancestries.
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  Data: <searchLink fieldCode="AU" term="%22Natividad+Avila+M%22">Natividad Avila M</searchLink>; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Jung+S%22">Jung S</searchLink>; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Satterstrom+FK%22">Satterstrom FK</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fu+JM%22">Fu JM</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Levy+T%22">Levy T</searchLink>; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sloofman+LG%22">Sloofman LG</searchLink>; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Klei+L%22">Klei L</searchLink>; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Pichardo+T%22">Pichardo T</searchLink>; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Marquez+D%22">Marquez D</searchLink>; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Stevens+CR%22">Stevens CR</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cusick+CM%22">Cusick CM</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ames+JL%22">Ames JL</searchLink>; Division of Research, Kaiser Permanente Northern, Pleasanton, CA, USA.<br /><searchLink fieldCode="AU" term="%22Campos+GS%22">Campos GS</searchLink>; Centro de Estudos do Genoma Humano e Células-Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brasil.<br /><searchLink fieldCode="AU" term="%22Cerros+H%22">Cerros H</searchLink>; Division of Research, Kaiser Permanente Northern, Pleasanton, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chaskel+R%22">Chaskel R</searchLink>; Facultad de Medicina, Universidad de los Andes, Bogotá, Colombia.; Instituto Colombiano del Sistema Nervioso, Clínica Montserrat, Bogotá, Colombia.<br /><searchLink fieldCode="AU" term="%22Costa+CIS%22">Costa CIS</searchLink>; Centro de Estudos do Genoma Humano e Células-Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brasil.<br /><searchLink fieldCode="AU" term="%22Cuccaro+ML%22">Cuccaro ML</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.; The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Lopez+ADP%22">Lopez ADP</searchLink>; Facultad de Medicina, Universidad de los Andes, Bogotá, Colombia.<br /><searchLink fieldCode="AU" term="%22Fernandez+M%22">Fernandez M</searchLink>; Instituto Colombiano del Sistema Nervioso, Clínica Montserrat, Bogotá, Colombia.<br /><searchLink fieldCode="AU" term="%22Ferro+E%22">Ferro E</searchLink>; Instituto Colombiano del Sistema Nervioso, Clínica Montserrat, Bogotá, Colombia.<br /><searchLink fieldCode="AU" term="%22Galeano+L%22">Galeano L</searchLink>; Facultad de Ciencias, Universidad de los Andes, Bogotá, Colombia.<br /><searchLink fieldCode="AU" term="%22Girardi+ACDES%22">Girardi ACDES</searchLink>; Centro de Estudos do Genoma Humano e Células-Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brasil.<br /><searchLink fieldCode="AU" term="%22Griswold+AJ%22">Griswold AJ</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.; The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Hernandez+LC%22">Hernandez LC</searchLink>; Facultad de Ciencias, Universidad de los Andes, Bogotá, Colombia.<br /><searchLink fieldCode="AU" term="%22Lourenço+N%22">Lourenço N</searchLink>; Centro de Estudos do Genoma Humano e Células-Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brasil.<br /><searchLink fieldCode="AU" term="%22Ludena+Y%22">Ludena Y</searchLink>; MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California, Davis, Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Núñez-Ríos+D%22">Núñez-Ríos D</searchLink>; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.; National Center of Posttraumatic Stress Disorders, VA CT Healthcare Center, West Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Oyama+R%22">Oyama R</searchLink>; Centro Ann Sullivan del Peru, Lima, Peru.<br /><searchLink fieldCode="AU" term="%22Peña+KP%22">Peña KP</searchLink>; Facultad de Ciencias, Universidad de los Andes, Bogotá, Colombia.<br /><searchLink fieldCode="AU" term="%22Pessah+I%22">Pessah I</searchLink>; MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California, Davis, Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Schmidt+R%22">Schmidt R</searchLink>; MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California, Davis, Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sweeney+HM%22">Sweeney HM</searchLink>; Center Ann Sullivan International, Lawrence, KS, USA.<br /><searchLink fieldCode="AU" term="%22Tolentino+L%22">Tolentino L</searchLink>; Centro Ann Sullivan del Peru, Lima, Peru.<br /><searchLink fieldCode="AU" term="%22Wang+JYT%22">Wang JYT</searchLink>; Centro de Estudos do Genoma Humano e Células-Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brasil.<br /><searchLink fieldCode="AU" term="%22Albores-Gallo+L%22">Albores-Gallo L</searchLink>; Hospital Psiquiátrico Infantil Dr. Juan N. Navarro, Mexico City, Mexico.; Universidad Nacional Autónoma de México, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Croen+LA%22">Croen LA</searchLink>; Division of Research, Kaiser Permanente Northern, Pleasanton, CA, USA.; Kaiser Permanente School of Medicine, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cruz-Fuentes+CS%22">Cruz-Fuentes CS</searchLink>; Departamento de Genética, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz México, Ciudad de México, Mexico.<br /><searchLink fieldCode="AU" term="%22Hertz-Picciotto+I%22">Hertz-Picciotto I</searchLink>; MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California, Davis, Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kolevzon+A%22">Kolevzon A</searchLink>; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lattig+MC%22">Lattig MC</searchLink>; Facultad de Ciencias, Universidad de los Andes, Bogotá, Colombia.<br /><searchLink fieldCode="AU" term="%22Mayo+L%22">Mayo L</searchLink>; Centro Ann Sullivan del Peru, Lima, Peru.<br /><searchLink fieldCode="AU" term="%22Passos-Bueno+MR%22">Passos-Bueno MR</searchLink>; Centro de Estudos do Genoma Humano e Células-Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brasil.<br /><searchLink fieldCode="AU" term="%22Pericak-Vance+MA%22">Pericak-Vance MA</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.; The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Siper+PM%22">Siper PM</searchLink>; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tassone+F%22">Tassone F</searchLink>; MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California, Davis, Davis, CA, USA.; Department of Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Trelles+MP%22">Trelles MP</searchLink>; Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Talkowski+ME%22">Talkowski ME</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Daly+MJ%22">Daly MJ</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Mahjani+B%22">Mahjani B</searchLink>; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22De+Rubeis+S%22">De Rubeis S</searchLink>; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Alper Center for Neural Development and Regeneration, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cook+EH%22">Cook EH</searchLink>; Department of Psychiatry, University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Roeder+K%22">Roeder K</searchLink>; Department of Statistics, Carnegie Mellon University, Pittsburgh, PA, USA.; Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Betancur+C%22">Betancur C</searchLink>; Sorbonne Université, INSERM, CNRS, Institut de Biologie Paris Seine, Center for Neuroscience at Sorbonne Université, Paris, France.<br /><searchLink fieldCode="AU" term="%22Devlin+B%22">Devlin B</searchLink>; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Buxbaum+JD%22">Buxbaum JD</searchLink>; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2026 Apr; Vol. 32 (4), pp. 1519-1529. <i>Date of Electronic Publication: </i>2026 Mar 30.
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