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Effect of Eplontersen in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy Across Genetic Variants: An Exploratory Analysis From the NEURO-TTRansform Trial.

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Title: Effect of Eplontersen in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy Across Genetic Variants: An Exploratory Analysis From the NEURO-TTRansform Trial.
Authors: Gillmore JD; National Amyloidosis Centre, University College London, London, UK., Adams D; Neurology Department, CHU de Bicêtre, AP-HP, Université Paris-Saclay, Le-Kremlin-Bicêtre, France., Weiler M; Amyloidosis Center and Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany., Masri A; Oregon Health & Science University, Portland, Oregon, USA., Obici L; Amyloidosis Research and Treatment Centre, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy., Nåtman J; BioPharmaceuticals Business Unit, AstraZeneca, Gothenburg, Sweden., Kwoh TJ; Clinical Development, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA., Reicher B; Late-Stage Development, Cardiovascular, Renal, and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA., Revkin J; Late-Stage Development, Cardiovascular, Renal, and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA., Cruz MW; CEPARM, Amyloidosis Center, University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Gertz M; Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA., Chao CC; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
Source: European journal of neurology [Eur J Neurol] 2026 Apr; Vol. 33 (4), pp. e70580.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 9506311 Publication Model: Print Cited Medium: Internet ISSN: 1468-1331 (Electronic) Linking ISSN: 13515101 NLM ISO Abbreviation: Eur J Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Effect of Eplontersen in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy Across Genetic Variants: An Exploratory Analysis From the NEURO-TTRansform Trial.
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  Data: <searchLink fieldCode="AU" term="%22Gillmore+JD%22">Gillmore JD</searchLink>; National Amyloidosis Centre, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Adams+D%22">Adams D</searchLink>; Neurology Department, CHU de Bicêtre, AP-HP, Université Paris-Saclay, Le-Kremlin-Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Weiler+M%22">Weiler M</searchLink>; Amyloidosis Center and Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Masri+A%22">Masri A</searchLink>; Oregon Health & Science University, Portland, Oregon, USA.<br /><searchLink fieldCode="AU" term="%22Obici+L%22">Obici L</searchLink>; Amyloidosis Research and Treatment Centre, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Nåtman+J%22">Nåtman J</searchLink>; BioPharmaceuticals Business Unit, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Kwoh+TJ%22">Kwoh TJ</searchLink>; Clinical Development, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA.<br /><searchLink fieldCode="AU" term="%22Reicher+B%22">Reicher B</searchLink>; Late-Stage Development, Cardiovascular, Renal, and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Revkin+J%22">Revkin J</searchLink>; Late-Stage Development, Cardiovascular, Renal, and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Cruz+MW%22">Cruz MW</searchLink>; CEPARM, Amyloidosis Center, University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Gertz+M%22">Gertz M</searchLink>; Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Chao+CC%22">Chao CC</searchLink>; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
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