Effect of a Lower Vs. Higher Positive End-Expiratory Pressure Strategy on Clinically Relevant Outcomes in ICU Patients Without Acute Respiratory Distress Syndrome: Bayesian Re-analysis of the REstricted Vs. Liberal Positive End-Expiratory Pressure in Patients Without Acute Respiratory Distress Syndrome (RELAx) Randomized Clinical Trial.
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| Title: | Effect of a Lower Vs. Higher Positive End-Expiratory Pressure Strategy on Clinically Relevant Outcomes in ICU Patients Without Acute Respiratory Distress Syndrome: Bayesian Re-analysis of the REstricted Vs. Liberal Positive End-Expiratory Pressure in Patients Without Acute Respiratory Distress Syndrome (RELAx) Randomized Clinical Trial. |
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| Authors: | Caroli A; Department of Intensive Care, Austin Hospital, Heidelberg, VIC, Australia.; Dipartimento di Scienze dell' Emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Algera AG; Department of Intensive Care, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands., van Meenen D; Department of Intensive Care, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands., Schultz MJ; Department of Intensive Care, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands., Paulus F; Department of Intensive Care, Amsterdam UMC, Location AMC, Amsterdam, The Netherlands., Neto AS; Department of Intensive Care, Austin Hospital, Heidelberg, VIC, Australia.; Australian and New Zeeland Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Austin Hospital, Melbourne, VIC, Australia.; Data Analytics Research and Evaluation (DARE) Centre, Austin Hospital, Melbourne, VIC, Australia.; Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil. |
| Corporate Authors: | REstricted vs. Liberal positive end-expiratory pressure in patients without Acute Respiratory Distress Syndrome (RELAx)—investigators and the PRotective Ventilation (PROVE) Network |
| Source: | Critical care medicine [Crit Care Med] 2026 Jun 01; Vol. 54 (6), pp. 1431-1441. Date of Electronic Publication: 2026 Mar 31. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Multicenter Study; Equivalence Trial |
| Journal Info: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0355501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0293 (Electronic) Linking ISSN: 00903493 NLM ISO Abbreviation: Crit Care Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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