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Nal-IRI (liposomal irinotecan) plus 5-fluorouracil and leucovorin versus 5-fluorouracil for metastatic pancreatic ductal adenocarcinoma following gemcitabine-based therapy. A systematic review and meta-analysis of randomized controlled trials.

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Title: Nal-IRI (liposomal irinotecan) plus 5-fluorouracil and leucovorin versus 5-fluorouracil for metastatic pancreatic ductal adenocarcinoma following gemcitabine-based therapy. A systematic review and meta-analysis of randomized controlled trials.
Authors: Vitale E; IRCCS Istituto Tumori 'Giovanni Paolo II', Viale Orazio Flacco 65, 70124, Bari, Italy., Rizzo A; IRCCS Istituto Tumori 'Giovanni Paolo II', Viale Orazio Flacco 65, 70124, Bari, Italy. rizzo.alessandro179@gmail.com.; TDM, IRCCS Istituto Tumori 'Giovanni Paolo II', Viale Orazio Flacco 65, 70124, Bari, Italy. rizzo.alessandro179@gmail.com., Maistrello L; IRCCS San Camillo Hospital, Venice, Italy., Sciacovelli AM; IRCCS Istituto Tumori 'Giovanni Paolo II', Viale Orazio Flacco 65, 70124, Bari, Italy., De Luca R; Department of Surgical Oncology, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy., Albano A; SSD Tumori Rari e Melanoma, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy., Fanizzi A; Laboratorio di Bioinformatica e Biostatistica, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy., Massafra R; Laboratorio di Bioinformatica e Biostatistica, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy., Lotesoriere C; Medical Oncology Unit, IRCCS Saverio de Bellis Hospital, Castellana Grotte, Italy., Gadaleta-Caldarola G; Oncology Unit, 'Mons. A. R. Dimiccoli' Hospital, 70051, Barletta, Italy., Pisconti S; Medical Oncology Division, 'San Giuseppe Moscati' Hospital, Taranto, Italy., Brunetti O; TDM, IRCCS Istituto Tumori 'Giovanni Paolo II', Viale Orazio Flacco 65, 70124, Bari, Italy.
Source: Clinical & experimental metastasis [Clin Exp Metastasis] 2026 Mar 31; Vol. 43 (2). Date of Electronic Publication: 2026 Mar 31.
Publication Type: Journal Article; Systematic Review; Meta-Analysis; Review
Journal Info: Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 8409970 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7276 (Electronic) Linking ISSN: 02620898 NLM ISO Abbreviation: Clin Exp Metastasis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Nal-IRI (liposomal irinotecan) plus 5-fluorouracil and leucovorin versus 5-fluorouracil for metastatic pancreatic ductal adenocarcinoma following gemcitabine-based therapy. A systematic review and meta-analysis of randomized controlled trials.
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  Data: <searchLink fieldCode="AU" term="%22Vitale+E%22">Vitale E</searchLink>; IRCCS Istituto Tumori 'Giovanni Paolo II', Viale Orazio Flacco 65, 70124, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Rizzo+A%22">Rizzo A</searchLink>; IRCCS Istituto Tumori 'Giovanni Paolo II', Viale Orazio Flacco 65, 70124, Bari, Italy. rizzo.alessandro179@gmail.com.; TDM, IRCCS Istituto Tumori 'Giovanni Paolo II', Viale Orazio Flacco 65, 70124, Bari, Italy. rizzo.alessandro179@gmail.com.<br /><searchLink fieldCode="AU" term="%22Maistrello+L%22">Maistrello L</searchLink>; IRCCS San Camillo Hospital, Venice, Italy.<br /><searchLink fieldCode="AU" term="%22Sciacovelli+AM%22">Sciacovelli AM</searchLink>; IRCCS Istituto Tumori 'Giovanni Paolo II', Viale Orazio Flacco 65, 70124, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22De+Luca+R%22">De Luca R</searchLink>; Department of Surgical Oncology, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Albano+A%22">Albano A</searchLink>; SSD Tumori Rari e Melanoma, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Fanizzi+A%22">Fanizzi A</searchLink>; Laboratorio di Bioinformatica e Biostatistica, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Massafra+R%22">Massafra R</searchLink>; Laboratorio di Bioinformatica e Biostatistica, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Lotesoriere+C%22">Lotesoriere C</searchLink>; Medical Oncology Unit, IRCCS Saverio de Bellis Hospital, Castellana Grotte, Italy.<br /><searchLink fieldCode="AU" term="%22Gadaleta-Caldarola+G%22">Gadaleta-Caldarola G</searchLink>; Oncology Unit, 'Mons. A. R. Dimiccoli' Hospital, 70051, Barletta, Italy.<br /><searchLink fieldCode="AU" term="%22Pisconti+S%22">Pisconti S</searchLink>; Medical Oncology Division, 'San Giuseppe Moscati' Hospital, Taranto, Italy.<br /><searchLink fieldCode="AU" term="%22Brunetti+O%22">Brunetti O</searchLink>; TDM, IRCCS Istituto Tumori 'Giovanni Paolo II', Viale Orazio Flacco 65, 70124, Bari, Italy.
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  Data: <searchLink fieldCode="JN" term="%228409970%22">Clinical & experimental metastasis</searchLink> [Clin Exp Metastasis] 2026 Mar 31; Vol. 43 (2). <i>Date of Electronic Publication: </i>2026 Mar 31.
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  Data: Journal Article; Systematic Review; Meta-Analysis; Review
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Kluwer+Academic+Publishers%22">Kluwer Academic Publishers </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8409970 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-7276 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202620898%22">02620898 </searchLink><i>NLM ISO Abbreviation: </i>Clin Exp Metastasis <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s10585-026-10401-5
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      – TitleFull: Nal-IRI (liposomal irinotecan) plus 5-fluorouracil and leucovorin versus 5-fluorouracil for metastatic pancreatic ductal adenocarcinoma following gemcitabine-based therapy. A systematic review and meta-analysis of randomized controlled trials.
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              Text: 2026 Mar 31
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