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Trisomy 21 Drives ADARB1 Overexpression and Premature RNA Recoding in the Developing Fetal Brain.

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Title: Trisomy 21 Drives ADARB1 Overexpression and Premature RNA Recoding in the Developing Fetal Brain.
Authors: Breen MS; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA. michael.breen@mssm.edu.; MINDICH Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. michael.breen@mssm.edu.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. michael.breen@mssm.edu.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. michael.breen@mssm.edu., Yang A; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; MINDICH Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wang X; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; MINDICH Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Rodriguez de Los Santos M; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; MINDICH Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tao R; The Lieber Institute for Brain Development, Baltimore, MD, USA., Weinberger DR; The Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Psychiatric and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Kleinman JE; The Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Psychiatric and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA., Mihova K; Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical Faculty, Medical University of Sofia, Sofia, Bulgaria., Stancheva G; Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical Faculty, Medical University of Sofia, Sofia, Bulgaria., Savova S; Department of Obstetrics and Gynecology, Medical University of Sofia, Sofia, Bulgaria.; Neonatology Clinic, University Hospital of Obstetrics and Gynecology 'Maichin Dom', Sofia, Bulgaria., Kaneva R; Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical Faculty, Medical University of Sofia, Sofia, Bulgaria., Dimitrova V; Department of Obstetrics and Gynecology, Medical University of Sofia, Sofia, Bulgaria.; Neonatology Clinic, University Hospital of Obstetrics and Gynecology 'Maichin Dom', Sofia, Bulgaria., Vladimirov V; The Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Psychiatry, The University of Arizona, Tucson, AZ, USA.; Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA., Hyde TM; The Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Psychiatric and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Buxbaum JD; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; MINDICH Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.
Source: Nature communications [Nat Commun] 2026 Mar 31; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 31.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Trisomy 21 Drives ADARB1 Overexpression and Premature RNA Recoding in the Developing Fetal Brain.
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  Data: <searchLink fieldCode="AU" term="%22Breen+MS%22">Breen MS</searchLink>; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA. michael.breen@mssm.edu.; MINDICH Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. michael.breen@mssm.edu.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. michael.breen@mssm.edu.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. michael.breen@mssm.edu.<br /><searchLink fieldCode="AU" term="%22Yang+A%22">Yang A</searchLink>; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; MINDICH Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; MINDICH Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+de+Los+Santos+M%22">Rodriguez de Los Santos M</searchLink>; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; MINDICH Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tao+R%22">Tao R</searchLink>; The Lieber Institute for Brain Development, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Weinberger+DR%22">Weinberger DR</searchLink>; The Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Psychiatric and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Kleinman+JE%22">Kleinman JE</searchLink>; The Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Psychiatric and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Mihova+K%22">Mihova K</searchLink>; Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical Faculty, Medical University of Sofia, Sofia, Bulgaria.<br /><searchLink fieldCode="AU" term="%22Stancheva+G%22">Stancheva G</searchLink>; Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical Faculty, Medical University of Sofia, Sofia, Bulgaria.<br /><searchLink fieldCode="AU" term="%22Savova+S%22">Savova S</searchLink>; Department of Obstetrics and Gynecology, Medical University of Sofia, Sofia, Bulgaria.; Neonatology Clinic, University Hospital of Obstetrics and Gynecology 'Maichin Dom', Sofia, Bulgaria.<br /><searchLink fieldCode="AU" term="%22Kaneva+R%22">Kaneva R</searchLink>; Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical Faculty, Medical University of Sofia, Sofia, Bulgaria.<br /><searchLink fieldCode="AU" term="%22Dimitrova+V%22">Dimitrova V</searchLink>; Department of Obstetrics and Gynecology, Medical University of Sofia, Sofia, Bulgaria.; Neonatology Clinic, University Hospital of Obstetrics and Gynecology 'Maichin Dom', Sofia, Bulgaria.<br /><searchLink fieldCode="AU" term="%22Vladimirov+V%22">Vladimirov V</searchLink>; The Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Psychiatry, The University of Arizona, Tucson, AZ, USA.; Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Hyde+TM%22">Hyde TM</searchLink>; The Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Psychiatric and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Buxbaum+JD%22">Buxbaum JD</searchLink>; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; MINDICH Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.
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