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Loss of GPRC5D enhances the proliferative capacity and competitive fitness of myeloma upon anti-GPRC5D immunotherapy.

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Title: Loss of GPRC5D enhances the proliferative capacity and competitive fitness of myeloma upon anti-GPRC5D immunotherapy.
Authors: Munawar U; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany., Thurner J; School of Life Sciences, Technical University of Munich, Freising, Germany., Nerreter S; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany., Nerreter T; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany., Leipold AM; Helmholtz Institute for RNA-based Infection Research, Helmholtz Centre for Infection Research, Wuerzburg, Germany.; Institute of Molecular Infection Biology, University of Wuerzburg, Wuerzburg, Germany., Han S; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany., Verbruggen C; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany., Gerhard-Hartmann E; Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany., Vogt C; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany., Grams B; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany., Kurian S; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany., Besant E; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany., Roth S; Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany., Weingart J; Department of Biotechnology and Biophysics, University of Wuerzburg, Wuerzburg, Germany., Eiring P; Department of Biotechnology and Biophysics, University of Wuerzburg, Wuerzburg, Germany., Truger M; MLL Munich Leukemia Laboratory, Munich, Germany., Afrin N; Mildred Scheel Early Career Center (MSNZ), University Hospital Wuerzburg, Wuerzburg, Germany., Steinbrunn T; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA., Tamamushi Y; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany., Zhou X; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany., Rein N; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany., Lehmann J; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany., Köppel M; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany., Rosenwald A; Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany., Haferlach C; MLL Munich Leukemia Laboratory, Munich, Germany., Hudecek M; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany., Saliba AE; Helmholtz Institute for RNA-based Infection Research, Helmholtz Centre for Infection Research, Wuerzburg, Germany.; Institute of Molecular Infection Biology, University of Wuerzburg, Wuerzburg, Germany., Rasche L; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.; Mildred Scheel Early Career Center (MSNZ), University Hospital Wuerzburg, Wuerzburg, Germany., Sauer M; Department of Biotechnology and Biophysics, University of Wuerzburg, Wuerzburg, Germany., Einsele H; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany., Kuster B; School of Life Sciences, Technical University of Munich, Freising, Germany., Waldschmidt J; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.; INTERACT Advanced Clinician Scientist-Program, University of Wuerzburg, Wuerzburg, Germany., Kortüm KM; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany. kortuem_m@ukw.de.
Source: Leukemia [Leukemia] 2026 Jun; Vol. 40 (6), pp. 1227-1239. Date of Electronic Publication: 2026 Mar 31.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
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  Data: Loss of GPRC5D enhances the proliferative capacity and competitive fitness of myeloma upon anti-GPRC5D immunotherapy.
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Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Verbruggen+C%22">Verbruggen C</searchLink>; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Gerhard-Hartmann+E%22">Gerhard-Hartmann E</searchLink>; Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Vogt+C%22">Vogt C</searchLink>; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Grams+B%22">Grams B</searchLink>; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kurian+S%22">Kurian S</searchLink>; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Besant+E%22">Besant E</searchLink>; 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Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA.<br /><searchLink fieldCode="AU" term="%22Tamamushi+Y%22">Tamamushi Y</searchLink>; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rein+N%22">Rein N</searchLink>; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Lehmann+J%22">Lehmann J</searchLink>; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Köppel+M%22">Köppel M</searchLink>; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rosenwald+A%22">Rosenwald A</searchLink>; Institute of Pathology, University of Wuerzburg, Wuerzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Haferlach+C%22">Haferlach C</searchLink>; MLL Munich Leukemia Laboratory, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hudecek+M%22">Hudecek M</searchLink>; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Saliba+AE%22">Saliba AE</searchLink>; Helmholtz Institute for RNA-based Infection Research, Helmholtz Centre for Infection Research, Wuerzburg, Germany.; Institute of Molecular Infection Biology, University of Wuerzburg, Wuerzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rasche+L%22">Rasche L</searchLink>; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.; Mildred Scheel Early Career Center (MSNZ), University Hospital Wuerzburg, Wuerzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Sauer+M%22">Sauer M</searchLink>; Department of Biotechnology and Biophysics, University of Wuerzburg, Wuerzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Einsele+H%22">Einsele H</searchLink>; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kuster+B%22">Kuster B</searchLink>; School of Life Sciences, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Waldschmidt+J%22">Waldschmidt J</searchLink>; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.; INTERACT Advanced Clinician Scientist-Program, University of Wuerzburg, Wuerzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kortüm+KM%22">Kortüm KM</searchLink>; Department of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany. kortuem_m@ukw.de.
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  Data: <searchLink fieldCode="JN" term="%228704895%22">Leukemia</searchLink> [Leukemia] 2026 Jun; Vol. 40 (6), pp. 1227-1239. <i>Date of Electronic Publication: </i>2026 Mar 31.
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