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Increased CSF levels of soluble AXL at diagnosis correlate with poor prognosis in patients affected by amyotrophic lateral sclerosis.

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Title: Increased CSF levels of soluble AXL at diagnosis correlate with poor prognosis in patients affected by amyotrophic lateral sclerosis.
Authors: Spatafora MG; Cellular and Molecular Neuropharmacology Laboratory, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Pavia, Italy., Dubin J; Laboratory for Molecular Neurobiomarker Research, Department of Neurosciences, Leuven Brain Institute, KU Leuven (University of Leuven), Leuven, Belgium.; Laboratory Medicine, UZ Leuven (University Hospitals Leuven), Leuven, Belgium., Domi T; Experimental Neuropathology Unit, Institute of Experimental Neurology (INSPE), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy., Lombardi R; 3rd Neurology Unit-Motor Neuron Disease Centre, Fondazione IRCCS Istituto Neurologico C. Besta, Milano, Italy., Cabras P; Cellular and Molecular Neuropharmacology Laboratory, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Pavia, Italy., Dalla Bella E; 3rd Neurology Unit-Motor Neuron Disease Centre, Fondazione IRCCS Istituto Neurologico C. Besta, Milano, Italy., Consonni M; 3rd Neurology Unit-Motor Neuron Disease Centre, Fondazione IRCCS Istituto Neurologico C. Besta, Milano, Italy., Quattrini A; Experimental Neuropathology Unit, Institute of Experimental Neurology (INSPE), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy., Verri M; Cellular and Molecular Neuropharmacology Laboratory, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Pavia, Italy., Lauria G; 3rd Neurology Unit-Motor Neuron Disease Centre, Fondazione IRCCS Istituto Neurologico C. Besta, Milano, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy., Van Damme P; Department of Neurology, UZ Leuven (University Hospitals Leuven), Leuven, Belgium.; Laboratory of Neurobiology, Department of Neurosciences, Leuven Brain Institute, KU Leuven (University of Leuven), Leuven, Belgium., Poesen K; Laboratory for Molecular Neurobiomarker Research, Department of Neurosciences, Leuven Brain Institute, KU Leuven (University of Leuven), Leuven, Belgium.; Laboratory Medicine, UZ Leuven (University Hospitals Leuven), Leuven, Belgium., Riva N; 3rd Neurology Unit-Motor Neuron Disease Centre, Fondazione IRCCS Istituto Neurologico C. Besta, Milano, Italy., Peviani M; Cellular and Molecular Neuropharmacology Laboratory, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Pavia, Italy.
Source: Brain communications [Brain Commun] 2026 Mar 30; Vol. 8 (2), pp. fcag086. Date of Electronic Publication: 2026 Mar 30 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101755125 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-1297 (Electronic) Linking ISSN: 26321297 NLM ISO Abbreviation: Brain Commun Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Increased CSF levels of soluble AXL at diagnosis correlate with poor prognosis in patients affected by amyotrophic lateral sclerosis.
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  Data: <searchLink fieldCode="AU" term="%22Spatafora+MG%22">Spatafora MG</searchLink>; Cellular and Molecular Neuropharmacology Laboratory, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Dubin+J%22">Dubin J</searchLink>; Laboratory for Molecular Neurobiomarker Research, Department of Neurosciences, Leuven Brain Institute, KU Leuven (University of Leuven), Leuven, Belgium.; Laboratory Medicine, UZ Leuven (University Hospitals Leuven), Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Domi+T%22">Domi T</searchLink>; Experimental Neuropathology Unit, Institute of Experimental Neurology (INSPE), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Lombardi+R%22">Lombardi R</searchLink>; 3rd Neurology Unit-Motor Neuron Disease Centre, Fondazione IRCCS Istituto Neurologico C. Besta, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Cabras+P%22">Cabras P</searchLink>; Cellular and Molecular Neuropharmacology Laboratory, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Dalla+Bella+E%22">Dalla Bella E</searchLink>; 3rd Neurology Unit-Motor Neuron Disease Centre, Fondazione IRCCS Istituto Neurologico C. Besta, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Consonni+M%22">Consonni M</searchLink>; 3rd Neurology Unit-Motor Neuron Disease Centre, Fondazione IRCCS Istituto Neurologico C. Besta, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Quattrini+A%22">Quattrini A</searchLink>; Experimental Neuropathology Unit, Institute of Experimental Neurology (INSPE), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Verri+M%22">Verri M</searchLink>; Cellular and Molecular Neuropharmacology Laboratory, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Lauria+G%22">Lauria G</searchLink>; 3rd Neurology Unit-Motor Neuron Disease Centre, Fondazione IRCCS Istituto Neurologico C. Besta, Milano, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Van+Damme+P%22">Van Damme P</searchLink>; Department of Neurology, UZ Leuven (University Hospitals Leuven), Leuven, Belgium.; Laboratory of Neurobiology, Department of Neurosciences, Leuven Brain Institute, KU Leuven (University of Leuven), Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Poesen+K%22">Poesen K</searchLink>; Laboratory for Molecular Neurobiomarker Research, Department of Neurosciences, Leuven Brain Institute, KU Leuven (University of Leuven), Leuven, Belgium.; Laboratory Medicine, UZ Leuven (University Hospitals Leuven), Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Riva+N%22">Riva N</searchLink>; 3rd Neurology Unit-Motor Neuron Disease Centre, Fondazione IRCCS Istituto Neurologico C. Besta, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Peviani+M%22">Peviani M</searchLink>; Cellular and Molecular Neuropharmacology Laboratory, Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Pavia, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101755125%22">Brain communications</searchLink> [Brain Commun] 2026 Mar 30; Vol. 8 (2), pp. fcag086. <i>Date of Electronic Publication: </i>2026 Mar 30 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101755125 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2632-1297 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226321297%22">26321297 </searchLink><i>NLM ISO Abbreviation: </i>Brain Commun <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2026 Mar 30
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