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A Self-Reinforcing LGR5-Wnt/β-Catenin-Nedd4L Circuit Drives Fibrotic Progression in Diabetic Kidney Disease.

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Title: A Self-Reinforcing LGR5-Wnt/β-Catenin-Nedd4L Circuit Drives Fibrotic Progression in Diabetic Kidney Disease.
Authors: Yu S; Department of Neuro Intensive Care Unit, Affiliated Jinyang Hospital of Guizhou Medical University, Guiyang Second People's Hospital, Guiyang, China.; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China., Wang F; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China.; Department of Pathology, Gulin County People's Hospital, Sichuan, China., Zhou X; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China.; Department of Pathology, College of Basic Medicine, Chongqing Medical University, Chongqing, China., Liang L; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China.; Guizhou Institute of Precision Medicine, Affiliated Hospital of Guizhou Medical University, Guiyang, China., Ruan Y; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China., Mo X; Department of Neuro Intensive Care Unit, Affiliated Jinyang Hospital of Guizhou Medical University, Guiyang Second People's Hospital, Guiyang, China.; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China., Li S; Department of Pathology, Guizhou Provincial People's Hospital, Guizhou, China., Tan W; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China., Xu X; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China., Jia J; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China., Peng J; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China., Long C; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China., Li M; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China., Zhu Y; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China., Mu Y; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China., Ran Y; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China., Ma X; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China., Liu L; Center for Clinical Laboratories, Affiliated Hospital of Guizhou Medical University, Guiyang, China., Guo B; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China., Wang Y; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China.
Source: Diabetes [Diabetes] 2026 Jun 01; Vol. 75 (6), pp. 951-964.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A Self-Reinforcing LGR5-Wnt/β-Catenin-Nedd4L Circuit Drives Fibrotic Progression in Diabetic Kidney Disease.
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  Data: <searchLink fieldCode="AU" term="%22Yu+S%22">Yu S</searchLink>; Department of Neuro Intensive Care Unit, Affiliated Jinyang Hospital of Guizhou Medical University, Guiyang Second People's Hospital, Guiyang, China.; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+F%22">Wang F</searchLink>; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China.; Department of Pathology, Gulin County People's Hospital, Sichuan, China.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; 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Department of Neuro Intensive Care Unit, Affiliated Jinyang Hospital of Guizhou Medical University, Guiyang Second People's Hospital, Guiyang, China.; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Department of Pathology, Guizhou Provincial People's Hospital, Guizhou, China.<br /><searchLink fieldCode="AU" term="%22Tan+W%22">Tan W</searchLink>; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; Department of Pathophysiology, Basic Medical College, Guizhou Medical University, Guizhou, China.; 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Guizhou Provincial Key Laboratory of Pathogenesis and Prevention of Common Chronic Diseases, Guizhou Medical University, Guizhou, China.
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  Data: <searchLink fieldCode="JN" term="%220372763%22">Diabetes</searchLink> [Diabetes] 2026 Jun 01; Vol. 75 (6), pp. 951-964.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Diabetes+Association%22">American Diabetes Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0372763 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1939-327X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200121797%22">00121797 </searchLink><i>NLM ISO Abbreviation: </i>Diabetes <i>Subsets: </i>MEDLINE
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