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Theta-gamma phase-amplitude coupling in the dynamic pain connectome in healthy individuals and abnormalities in people with chronic pain.

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Title: Theta-gamma phase-amplitude coupling in the dynamic pain connectome in healthy individuals and abnormalities in people with chronic pain.
Authors: Seyed Makki A; Division of Brain, Imaging and Behaviour, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada., Hemington KS; Division of Brain, Imaging and Behaviour, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada., Rogachov A; Division of Brain, Imaging and Behaviour, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada., Cheng JC; Division of Brain, Imaging and Behaviour, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada., Bosma RL; Division of Brain, Imaging and Behaviour, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada., Osborne NR; Division of Brain, Imaging and Behaviour, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada., El-Sayed R; Division of Brain, Imaging and Behaviour, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada., Inman RD; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.; Department of Immunology, University of Toronto, Toronto, Ontario, Canada., Dunkley BT; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.; Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada.; Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada.; Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada.; Department of Psychology, University of Nottingham, Nottingham, United Kingdom., Davis KD; Division of Brain, Imaging and Behaviour, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.; Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Source: Journal of neurophysiology [J Neurophysiol] 2026 Apr 01; Vol. 135 (4), pp. 951-964. Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 0375404 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1598 (Electronic) Linking ISSN: 00223077 NLM ISO Abbreviation: J Neurophysiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Theta-gamma phase-amplitude coupling in the dynamic pain connectome in healthy individuals and abnormalities in people with chronic pain.
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  Data: <searchLink fieldCode="AU" term="%22Seyed+Makki+A%22">Seyed Makki A</searchLink>; Division of Brain, Imaging and Behaviour, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Hemington+KS%22">Hemington KS</searchLink>; Division of Brain, Imaging and Behaviour, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Rogachov+A%22">Rogachov A</searchLink>; Division of Brain, Imaging and Behaviour, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Cheng+JC%22">Cheng JC</searchLink>; Division of Brain, Imaging and Behaviour, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Bosma+RL%22">Bosma RL</searchLink>; Division of Brain, Imaging and Behaviour, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Osborne+NR%22">Osborne NR</searchLink>; Division of Brain, Imaging and Behaviour, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22El-Sayed+R%22">El-Sayed R</searchLink>; Division of Brain, Imaging and Behaviour, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Inman+RD%22">Inman RD</searchLink>; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Dunkley+BT%22">Dunkley BT</searchLink>; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.; Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada.; Neurosciences and Mental Health Program, SickKids Research Institute, Toronto, Ontario, Canada.; Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada.; Department of Psychology, University of Nottingham, Nottingham, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Davis+KD%22">Davis KD</searchLink>; Division of Brain, Imaging and Behaviour, Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.; Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
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        Value: 10.1152/jn.00492.2025
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        Text: English
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              Text: 2026 Apr 01
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