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Site-specific methylation of SRSF2P95H by SETD2 inhibits MDSC-mediated proinflammatory niche formation in mouse models of myelodysplastic syndrome.

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Title: Site-specific methylation of SRSF2P95H by SETD2 inhibits MDSC-mediated proinflammatory niche formation in mouse models of myelodysplastic syndrome.
Authors: Li ZJ; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Zhao MY; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Wang R; Department of Hematology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200025, China., Liu N; Department of Hematology, Institute of Hematology, Changhai Hospital, Naval Medical University, Shanghai 200433, China., Hu CL; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Chang B; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Hu F; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, P. R. China.; Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, P. R. China., Li XY; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Xu CH; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Liu P; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Chen BY; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Chen SB; Shanghai Jiao Tong University School of Life Sciences and Biotechnology, Shanghai 200025, China., Wang Y; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Li QJ; Department of Hematology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China., Xue BS; Department of Hematology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China., Deng C; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Chen X; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Ren Y; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Jia-Cheng Jin; Department of Hematology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200025, China., Yan X; Department of Hematology, First Affiliated Hospital of Ningbo University, Ningbo Clinical Research Center for Hematologic Malignancies, Ningbo 315010, China., Zhang Y; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Gale RP; Centre for Hematology, Department of Immunology and Inflammation, Imperial College of Science, Technology & Medicine, London W12 0NN, UK., Fu J; Department of Hematology, Tongji Hospital of Tongji University, Tongji University School of Medicine, Shanghai 200092, China., Zhang QL; Department of Medical Oncology, Fudan University, Shanghai 200433, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200433, China., Wang X; Department of Hematology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China., Huang Q; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Liu Y; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Qiu J; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Qin J; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China., Ye X; Department of Hematology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China., Zhang J; Department of Hematology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China., Liang Y; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, P. R. China.; Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, P. R. China., Chen Z; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., Chen SJ; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China., He PC; Department of Hematology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China., Chang CK; Department of Hematology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200025, China., Sun XJ; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.; Shanghai Jiao Tong University School of Life Sciences and Biotechnology, Shanghai 200025, China., Wang L; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Source: Science translational medicine [Sci Transl Med] 2026 Apr; Vol. 18 (843), pp. eadv1065. Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: Site-specific methylation of SRSF2<superscript>P95H</superscript> by SETD2 inhibits MDSC-mediated proinflammatory niche formation in mouse models of myelodysplastic syndrome.
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  Data: <searchLink fieldCode="AU" term="%22Li+ZJ%22">Li ZJ</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.<br /><searchLink fieldCode="AU" term="%22Zhao+MY%22">Zhao MY</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Wang+R%22">Wang R</searchLink>; Department of Hematology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200025, China.<br /><searchLink fieldCode="AU" term="%22Liu+N%22">Liu N</searchLink>; Department of Hematology, Institute of Hematology, Changhai Hospital, Naval Medical University, Shanghai 200433, China.<br /><searchLink fieldCode="AU" term="%22Hu+CL%22">Hu CL</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Chang+B%22">Chang B</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Hu+F%22">Hu F</searchLink>; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, P. R. China.; Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, P. R. China.<br /><searchLink fieldCode="AU" term="%22Li+XY%22">Li XY</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Xu+CH%22">Xu CH</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Liu+P%22">Liu P</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Chen+BY%22">Chen BY</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Chen+SB%22">Chen SB</searchLink>; Shanghai Jiao Tong University School of Life Sciences and Biotechnology, Shanghai 200025, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Li+QJ%22">Li QJ</searchLink>; Department of Hematology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.<br /><searchLink fieldCode="AU" term="%22Xue+BS%22">Xue BS</searchLink>; Department of Hematology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.<br /><searchLink fieldCode="AU" term="%22Deng+C%22">Deng C</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Ren+Y%22">Ren Y</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Jia-Cheng+Jin%22">Jia-Cheng Jin</searchLink>; Department of Hematology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200025, China.<br /><searchLink fieldCode="AU" term="%22Yan+X%22">Yan X</searchLink>; Department of Hematology, First Affiliated Hospital of Ningbo University, Ningbo Clinical Research Center for Hematologic Malignancies, Ningbo 315010, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.<br /><searchLink fieldCode="AU" term="%22Gale+RP%22">Gale RP</searchLink>; Centre for Hematology, Department of Immunology and Inflammation, Imperial College of Science, Technology & Medicine, London W12 0NN, UK.<br /><searchLink fieldCode="AU" term="%22Fu+J%22">Fu J</searchLink>; Department of Hematology, Tongji Hospital of Tongji University, Tongji University School of Medicine, Shanghai 200092, China.<br /><searchLink fieldCode="AU" term="%22Zhang+QL%22">Zhang QL</searchLink>; Department of Medical Oncology, Fudan University, Shanghai 200433, China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200433, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Hematology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.<br /><searchLink fieldCode="AU" term="%22Huang+Q%22">Huang Q</searchLink>; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22Qiu+J%22">Qiu J</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Qin+J%22">Qin J</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.<br /><searchLink fieldCode="AU" term="%22Ye+X%22">Ye X</searchLink>; Department of Hematology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Hematology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.<br /><searchLink fieldCode="AU" term="%22Liang+Y%22">Liang Y</searchLink>; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, P. R. China.; Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, P. R. China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.<br /><searchLink fieldCode="AU" term="%22Chen+SJ%22">Chen SJ</searchLink>; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.<br /><searchLink fieldCode="AU" term="%22He+PC%22">He PC</searchLink>; Department of Hematology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.<br /><searchLink fieldCode="AU" term="%22Chang+CK%22">Chang CK</searchLink>; Department of Hematology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200025, China.<br /><searchLink fieldCode="AU" term="%22Sun+XJ%22">Sun XJ</searchLink>; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.; Shanghai Jiao Tong University School of Life Sciences and Biotechnology, Shanghai 200025, China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
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