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Beta cell-targeted PD-1 agonist inhibits cell-mediated autoimmunity in pancreas tissue slices.

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Title: Beta cell-targeted PD-1 agonist inhibits cell-mediated autoimmunity in pancreas tissue slices.
Authors: Becker MW; J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, USA., Brown ME; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.; University of Florida Diabetes Institute, University of Florida, Gainesville, FL, USA., Wiseman K; Immunocore Ltd., Abingdon, UK., Chiodetti AL; Immunocore Ltd., Abingdon, UK., Huber MK; J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, USA.; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.; University of Florida Diabetes Institute, University of Florida, Gainesville, FL, USA., Cuaycal AE; J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, USA.; University of Florida Diabetes Institute, University of Florida, Gainesville, FL, USA.; Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA., Sintara P; J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, USA., Ferreira SM; J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, USA., Smurlick D; J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, USA., Barra JM; University of Florida Diabetes Institute, University of Florida, Gainesville, FL, USA.; Department of Pharmacology & Therapeutics, College of Medicine, University of Florida, Gainesville, FL, USA., Ladd AM; University of Florida Diabetes Institute, University of Florida, Gainesville, FL, USA.; Department of Pharmacology & Therapeutics, College of Medicine, University of Florida, Gainesville, FL, USA., Drotar DM; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.; University of Florida Diabetes Institute, University of Florida, Gainesville, FL, USA., Atkinson MA; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.; University of Florida Diabetes Institute, University of Florida, Gainesville, FL, USA.; Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL, USA., Weber P; Immunocore Ltd., Abingdon, UK., Al-Mossawi H; Immunocore Ltd., Abingdon, UK., Russ HA; University of Florida Diabetes Institute, University of Florida, Gainesville, FL, USA.; Department of Pharmacology & Therapeutics, College of Medicine, University of Florida, Gainesville, FL, USA., Mahon TM; Immunocore Ltd., Abingdon, UK., Brusko TM; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.; University of Florida Diabetes Institute, University of Florida, Gainesville, FL, USA.; Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL, USA.; Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, USA., Bossi G; Immunocore Ltd., Abingdon, UK., Phelps EA; J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, USA.; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.; University of Florida Diabetes Institute, University of Florida, Gainesville, FL, USA.
Source: Science advances [Sci Adv] 2026 Apr 03; Vol. 12 (14), pp. eaec9029. Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: Beta cell-targeted PD-1 agonist inhibits cell-mediated autoimmunity in pancreas tissue slices.
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  Data: <searchLink fieldCode="AU" term="%22Becker+MW%22">Becker MW</searchLink>; J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Brown+ME%22">Brown ME</searchLink>; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.; University of Florida Diabetes Institute, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Wiseman+K%22">Wiseman K</searchLink>; Immunocore Ltd., Abingdon, UK.<br /><searchLink fieldCode="AU" term="%22Chiodetti+AL%22">Chiodetti AL</searchLink>; Immunocore Ltd., Abingdon, UK.<br /><searchLink fieldCode="AU" term="%22Huber+MK%22">Huber MK</searchLink>; J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, USA.; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.; University of Florida Diabetes Institute, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Cuaycal+AE%22">Cuaycal AE</searchLink>; J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, USA.; University of Florida Diabetes Institute, University of Florida, Gainesville, FL, USA.; Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Sintara+P%22">Sintara P</searchLink>; J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Ferreira+SM%22">Ferreira SM</searchLink>; J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Smurlick+D%22">Smurlick D</searchLink>; J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Barra+JM%22">Barra JM</searchLink>; University of Florida Diabetes Institute, University of Florida, Gainesville, FL, USA.; Department of Pharmacology & Therapeutics, College of Medicine, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Ladd+AM%22">Ladd AM</searchLink>; University of Florida Diabetes Institute, University of Florida, Gainesville, FL, USA.; Department of Pharmacology & Therapeutics, College of Medicine, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Drotar+DM%22">Drotar DM</searchLink>; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.; University of Florida Diabetes Institute, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Atkinson+MA%22">Atkinson MA</searchLink>; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.; University of Florida Diabetes Institute, University of Florida, Gainesville, FL, USA.; Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Weber+P%22">Weber P</searchLink>; Immunocore Ltd., Abingdon, UK.<br /><searchLink fieldCode="AU" term="%22Al-Mossawi+H%22">Al-Mossawi H</searchLink>; Immunocore Ltd., Abingdon, UK.<br /><searchLink fieldCode="AU" term="%22Russ+HA%22">Russ HA</searchLink>; University of Florida Diabetes Institute, University of Florida, Gainesville, FL, USA.; Department of Pharmacology & Therapeutics, College of Medicine, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Mahon+TM%22">Mahon TM</searchLink>; Immunocore Ltd., Abingdon, UK.<br /><searchLink fieldCode="AU" term="%22Brusko+TM%22">Brusko TM</searchLink>; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.; University of Florida Diabetes Institute, University of Florida, Gainesville, FL, USA.; Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL, USA.; Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Bossi+G%22">Bossi G</searchLink>; Immunocore Ltd., Abingdon, UK.<br /><searchLink fieldCode="AU" term="%22Phelps+EA%22">Phelps EA</searchLink>; J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, USA.; Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.; University of Florida Diabetes Institute, University of Florida, Gainesville, FL, USA.
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