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Hepatic supersulfides attenuate acetaminophen-induced liver injury via enhanced detoxification and anti-inflammatory mechanisms.

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Title: Hepatic supersulfides attenuate acetaminophen-induced liver injury via enhanced detoxification and anti-inflammatory mechanisms.
Authors: Guo C; Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, Japan., Toyomoto T; Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, Japan; Transkingdom Signaling Research Unit, Division of Host Defense Mechanism, Tokai University School of Medicine, Japan., Tsutsuki H; Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, Japan., Fujiwara Y; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, Japan., Komohara Y; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, Japan., Zhang T; Comprehensive Center for Infectious Disease Control, Akita University Graduate School of Medicine, Hondo 1-1-1, Akita, Japan; Key Research Laboratory at Akita University, Hondo 1-1-1, Akita, Japan., Honda H; Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, Japan., Lindahl S; Department of Chemistry, Brown University, Providence, RI, 02912, USA., Niidome T; Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan., Fang J; Faculty of Pharmaceutical Science, Sojo University, Ikeda 4-22-1, Kumamoto, Japan., Xian M; Department of Chemistry, Brown University, Providence, RI, 02912, USA., Sawa T; Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, Japan. Electronic address: sawat@kumamoto-u.ac.jp.
Source: Redox biology [Redox Biol] 2026 May; Vol. 92, pp. 104140. Date of Electronic Publication: 2026 Mar 28.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE
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  Data: Hepatic supersulfides attenuate acetaminophen-induced liver injury via enhanced detoxification and anti-inflammatory mechanisms.
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  Data: <searchLink fieldCode="AU" term="%22Guo+C%22">Guo C</searchLink>; Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Toyomoto+T%22">Toyomoto T</searchLink>; Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, Japan; Transkingdom Signaling Research Unit, Division of Host Defense Mechanism, Tokai University School of Medicine, Japan.<br /><searchLink fieldCode="AU" term="%22Tsutsuki+H%22">Tsutsuki H</searchLink>; Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Fujiwara+Y%22">Fujiwara Y</searchLink>; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Komohara+Y%22">Komohara Y</searchLink>; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Zhang+T%22">Zhang T</searchLink>; Comprehensive Center for Infectious Disease Control, Akita University Graduate School of Medicine, Hondo 1-1-1, Akita, Japan; Key Research Laboratory at Akita University, Hondo 1-1-1, Akita, Japan.<br /><searchLink fieldCode="AU" term="%22Honda+H%22">Honda H</searchLink>; Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Lindahl+S%22">Lindahl S</searchLink>; Department of Chemistry, Brown University, Providence, RI, 02912, USA.<br /><searchLink fieldCode="AU" term="%22Niidome+T%22">Niidome T</searchLink>; Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Fang+J%22">Fang J</searchLink>; Faculty of Pharmaceutical Science, Sojo University, Ikeda 4-22-1, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Xian+M%22">Xian M</searchLink>; Department of Chemistry, Brown University, Providence, RI, 02912, USA.<br /><searchLink fieldCode="AU" term="%22Sawa+T%22">Sawa T</searchLink>; Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1-1-1, Chuo-ku, Kumamoto, Japan. Electronic address: sawat@kumamoto-u.ac.jp.
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  Data: <searchLink fieldCode="JN" term="%22101605639%22">Redox biology</searchLink> [Redox Biol] 2026 May; Vol. 92, pp. 104140. <i>Date of Electronic Publication: </i>2026 Mar 28.
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