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Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation.

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Title: Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation.
Authors: Zhang K; Department of Urology, Peking University First Hospital, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China.; Department of Urology, The First Hospital Affiliated to Zhengzhou University, Henan, China., He L; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking University, Beijing, China. linhe@bjmu.edu.cn.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, China. linhe@bjmu.edu.cn., Wang Y; Department of Urology, Peking University First Hospital, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China., Qin S; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, China., Yu C; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China., Zheng E; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, China., Zhang Z; Department of Urology, Peking University First Hospital, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China., Xu Y; Department of Urology, Peking University First Hospital, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China., Chen X; Department of Urology, Peking University First Hospital, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China., Liu Y; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking University, Beijing, China.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, China., Liu X; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking University, Beijing, China.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, China., Guan S; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, China., Xia L; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, China., Suo F; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, China., Pei F; Department of Pathology, Peking University Health Science Center, Beijing, China., Du J; Department of Pathology, Peking University Health Science Center, Beijing, China., Su Y; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, China., Li Y; CapitalBio Technology Co., Ltd., Beijing, China., Wu Y; Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China., Zhou X; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, China., Zhou J; Department of Urology, Peking University First Hospital, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China., Cai L; Department of Urology, Peking University First Hospital, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China., Tang X; Chemical Biology Center, School of Pharmaceutical Sciences, Peking University, Beijing, China., Zhang Z; Department of Urology, Peking University First Hospital, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China., Shang Y; National Center for Children's Health, Beijing Children's Hospital, Beijing, China., Zhang Q; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Qing.Zhang@UTSouthwestern.edu., Gong K; Department of Urology, Peking University First Hospital, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China. gongkan_pku@126.com., Sun L; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking University, Beijing, China. luyang_sun@hsc.pku.edu.cn.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, China. luyang_sun@hsc.pku.edu.cn.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Apr 01; Vol. 11 (1). Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+K%22">Zhang K</searchLink>; Department of Urology, Peking University First Hospital, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China.; Department of Urology, The First Hospital Affiliated to Zhengzhou University, Henan, China.<br /><searchLink fieldCode="AU" term="%22He+L%22">He L</searchLink>; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking University, Beijing, China. linhe@bjmu.edu.cn.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, China. linhe@bjmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Urology, Peking University First Hospital, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Qin+S%22">Qin S</searchLink>; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Yu+C%22">Yu C</searchLink>; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zheng+E%22">Zheng E</searchLink>; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Department of Urology, Peking University First Hospital, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Department of Urology, Peking University First Hospital, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Department of Urology, Peking University First Hospital, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking University, Beijing, China.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking University, Beijing, China.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Guan+S%22">Guan S</searchLink>; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Xia+L%22">Xia L</searchLink>; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Suo+F%22">Suo F</searchLink>; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Pei+F%22">Pei F</searchLink>; Department of Pathology, Peking University Health Science Center, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Du+J%22">Du J</searchLink>; Department of Pathology, Peking University Health Science Center, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Su+Y%22">Su Y</searchLink>; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; CapitalBio Technology Co., Ltd., Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; Department of Urology, Peking University First Hospital, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Cai+L%22">Cai L</searchLink>; Department of Urology, Peking University First Hospital, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Tang+X%22">Tang X</searchLink>; Chemical Biology Center, School of Pharmaceutical Sciences, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Department of Urology, Peking University First Hospital, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Shang+Y%22">Shang Y</searchLink>; National Center for Children's Health, Beijing Children's Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Qing.Zhang@UTSouthwestern.edu.<br /><searchLink fieldCode="AU" term="%22Gong+K%22">Gong K</searchLink>; Department of Urology, Peking University First Hospital, State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China. gongkan_pku@126.com.<br /><searchLink fieldCode="AU" term="%22Sun+L%22">Sun L</searchLink>; Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking University, Beijing, China. luyang_sun@hsc.pku.edu.cn.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, China. luyang_sun@hsc.pku.edu.cn.
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