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Hydrostatic pressure promotes odontoblast differentiation via PIEZO1-dependent activation of RUNX2 and WNT16 in SHED.

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Title: Hydrostatic pressure promotes odontoblast differentiation via PIEZO1-dependent activation of RUNX2 and WNT16 in SHED.
Authors: Miyazaki A; Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794, USA.; Department of Pediatric Dentistry, Graduate School of Oral Sciences, Tokushima University Graduate School, Tokushima, 770-8504, Japan., Narwidina A; Department of Pediatric Dentistry, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia., Sugimoto A; Department of Pediatric Dentistry, Graduate School of Oral Sciences, Tokushima University Graduate School, Tokushima, 770-8504, Japan.; Department of Pediatric Dentistry/Special Needs Dentistry, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, 113-8549, Japan., Kurogoushi R; Department of Pediatric Dentistry, Graduate School of Oral Sciences, Tokushima University Graduate School, Tokushima, 770-8504, Japan.; Department of Pediatric Dentistry/Special Needs Dentistry, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, 113-8549, Japan., Nakashima Y; Department of Pediatric Dentistry/Special Needs Dentistry, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, 113-8549, Japan., Hashimoto N; Department of Tissue Regeneration, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 770-8504, Japan., Yamamoto A; Department of Tissue Regeneration, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 770-8504, Japan., Iwamoto T; Department of Pediatric Dentistry, Graduate School of Oral Sciences, Tokushima University Graduate School, Tokushima, 770-8504, Japan. iwamoto.dohs@tmd.ac.jp.; Department of Pediatric Dentistry/Special Needs Dentistry, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, 113-8549, Japan. iwamoto.dohs@tmd.ac.jp.
Source: Scientific reports [Sci Rep] 2026 Apr 01; Vol. 16 (1). Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: Hydrostatic pressure promotes odontoblast differentiation via PIEZO1-dependent activation of RUNX2 and WNT16 in SHED.
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  Data: <searchLink fieldCode="AU" term="%22Miyazaki+A%22">Miyazaki A</searchLink>; Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794, USA.; Department of Pediatric Dentistry, Graduate School of Oral Sciences, Tokushima University Graduate School, Tokushima, 770-8504, Japan.<br /><searchLink fieldCode="AU" term="%22Narwidina+A%22">Narwidina A</searchLink>; Department of Pediatric Dentistry, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia.<br /><searchLink fieldCode="AU" term="%22Sugimoto+A%22">Sugimoto A</searchLink>; Department of Pediatric Dentistry, Graduate School of Oral Sciences, Tokushima University Graduate School, Tokushima, 770-8504, Japan.; Department of Pediatric Dentistry/Special Needs Dentistry, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, 113-8549, Japan.<br /><searchLink fieldCode="AU" term="%22Kurogoushi+R%22">Kurogoushi R</searchLink>; Department of Pediatric Dentistry, Graduate School of Oral Sciences, Tokushima University Graduate School, Tokushima, 770-8504, Japan.; Department of Pediatric Dentistry/Special Needs Dentistry, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, 113-8549, Japan.<br /><searchLink fieldCode="AU" term="%22Nakashima+Y%22">Nakashima Y</searchLink>; Department of Pediatric Dentistry/Special Needs Dentistry, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, 113-8549, Japan.<br /><searchLink fieldCode="AU" term="%22Hashimoto+N%22">Hashimoto N</searchLink>; Department of Tissue Regeneration, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 770-8504, Japan.<br /><searchLink fieldCode="AU" term="%22Yamamoto+A%22">Yamamoto A</searchLink>; Department of Tissue Regeneration, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 770-8504, Japan.<br /><searchLink fieldCode="AU" term="%22Iwamoto+T%22">Iwamoto T</searchLink>; Department of Pediatric Dentistry, Graduate School of Oral Sciences, Tokushima University Graduate School, Tokushima, 770-8504, Japan. iwamoto.dohs@tmd.ac.jp.; Department of Pediatric Dentistry/Special Needs Dentistry, Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, 113-8549, Japan. iwamoto.dohs@tmd.ac.jp.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2026 Apr 01; Vol. 16 (1). <i>Date of Electronic Publication: </i>2026 Apr 01.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101563288 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2045-2322 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220452322%22">20452322 </searchLink><i>NLM ISO Abbreviation: </i>Sci Rep <i>Subsets: </i>MEDLINE
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              Text: 2026 Apr 01
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