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DNA damage burden causes selective CUX2 neuron loss in neuroinflammation.

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Title: DNA damage burden causes selective CUX2 neuron loss in neuroinflammation.
Authors: Morcom L; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; UK Dementia Research Institute at the University of Cambridge, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Xia W; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Xu Z; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK.; Department of Pediatrics, Cedars-Sinai Guerin Children's, Los Angeles, CA, USA.; Department of Neurosurgery, Cedars-Sinai Guerin Children's, Los Angeles, CA, USA., Awasthi Y; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Geywitz C; Division of Neuroimmunology, Department of Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Ellis MO; UK Dementia Research Institute at the University of Cambridge, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Noli T; Division of Neuroimmunology, Department of Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Zulji A; Division of Neuroimmunology, Department of Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Yamamoto D; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Girdler GC; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Kai L; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Zhu K; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Wei M; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Tang XY; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Hoi KK; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Gonzalez-Maya J; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Duncan GJ; Department of Neurology, Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, USA., Vaquie AM; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Gold Diaz D; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Kawaguchi R; Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Department of Neurology, University of California Los Angeles, Los Angeles, CA, USA., Liu E; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Sun Y; UK Dementia Research Institute at the University of Cambridge, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Yang D; UK Dementia Research Institute at the University of Cambridge, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Jordan GD; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Lu IL; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.; Department of Pediatrics, Division of Neonatology, University of California San Francisco, San Francisco, CA, USA., Holmqvist S; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Bartels T; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Ridley K; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Choi JJ; Department of Pathology, University of California San Francisco, San Francisco, CA, USA., Franco SJ; Department of Pediatrics, Section of Developmental Biology, University of Colorado-Anschutz Medical Campus, Denver, CO, USA., Huang EJ; Department of Pathology, University of California San Francisco, San Francisco, CA, USA., Emery B; Jungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University, Portland, OR, USA., Geschwind D; Department of Neurology, University of California Los Angeles, Los Angeles, CA, USA.; Program in Neurogenetics, Departments of Neurology and Human Genetics, Institute of Precision Health, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Center for Autism Research and Treatment, Department of Psychiatry and Semel Institute, University of California Los Angeles, Los Angeles, CA, USA., Schirmer L; Division of Neuroimmunology, Department of Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Interdisciplinary Center for Neurosciences, Heidelberg University, Heidelberg, Germany.; Center for Translational Neuroscience and Institute for Innate Immunoscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Balmus G; UK Dementia Research Institute at the University of Cambridge, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.; Department of Molecular Neuroscience, Transylvanian Institute of Neuroscience, Cluj-Napoca, Romania., Popko B; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Fancy SPJ; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California San Francisco, San Francisco, CA, USA. stephen.fancy@ucsf.edu., Rowitch DH; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. david.rowitch@csmc.edu.; Department of Paediatrics, University of Cambridge, Cambridge, UK. david.rowitch@csmc.edu.; Department of Pediatrics, Cedars-Sinai Guerin Children's, Los Angeles, CA, USA. david.rowitch@csmc.edu.; Department of Neurosurgery, Cedars-Sinai Guerin Children's, Los Angeles, CA, USA. david.rowitch@csmc.edu.; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA. david.rowitch@csmc.edu.; Department of Pediatrics, Division of Neonatology, University of California San Francisco, San Francisco, CA, USA. david.rowitch@csmc.edu.
Source: Nature [Nature] 2026 May; Vol. 653 (8115), pp. 809-818. Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: DNA damage burden causes selective CUX2 neuron loss in neuroinflammation.
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  Data: <searchLink fieldCode="AU" term="%22Morcom+L%22">Morcom L</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; UK Dementia Research Institute at the University of Cambridge, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Xia+W%22">Xia W</searchLink>; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Xu+Z%22">Xu Z</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK.; Department of Pediatrics, Cedars-Sinai Guerin Children's, Los Angeles, CA, USA.; Department of Neurosurgery, Cedars-Sinai Guerin Children's, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Awasthi+Y%22">Awasthi Y</searchLink>; 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The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA. david.rowitch@csmc.edu.; Department of Pediatrics, Division of Neonatology, University of California San Francisco, San Francisco, CA, USA. david.rowitch@csmc.edu.
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