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Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair.

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Title: Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair.
Authors: Xia W; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Morcom L; Department of Paediatrics, University of Cambridge, Cambridge, UK.; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Xu Z; Department of Paediatrics, University of Cambridge, Cambridge, UK.; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Pediatrics, Cedars Sinai Guerin Children's, Los Angeles, CA, USA.; Department of Neurosurgery, Cedars Sinai Guerin Children's, Los Angeles, CA, USA., Lu IL; Institute for Regenerative Medicine, University of California, San Francisco, San Francisco, CA, USA., Wang Q; Department of Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Hoi KK; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Wei M; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Zhu K; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Jordan G; Department of Paediatrics, University of Cambridge, Cambridge, UK.; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Tang XY; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Gonzalez-Maya J; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Mattera VS; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Panigrahi SM; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Kawaguchi R; Department of Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Emery B; Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, USA., Franco SJ; Department of Pediatrics, University of Colorado Anschutz School of Medicine, Aurora, CO, USA., Geschwind DH; Department of Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Popko B; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Rowitch DH; Department of Paediatrics, University of Cambridge, Cambridge, UK. dhr25@cam.ac.uk.; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. dhr25@cam.ac.uk.; Department of Pediatrics, Cedars Sinai Guerin Children's, Los Angeles, CA, USA. dhr25@cam.ac.uk.; Department of Neurosurgery, Cedars Sinai Guerin Children's, Los Angeles, CA, USA. dhr25@cam.ac.uk.; Institute for Regenerative Medicine, University of California, San Francisco, San Francisco, CA, USA. dhr25@cam.ac.uk., Fancy SPJ; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. stephen.fancy@ucsf.edu.
Source: Nature [Nature] 2026 May; Vol. 653 (8115), pp. 819-830. Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair.
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  Data: <searchLink fieldCode="AU" term="%22Xia+W%22">Xia W</searchLink>; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Morcom+L%22">Morcom L</searchLink>; Department of Paediatrics, University of Cambridge, Cambridge, UK.; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Xu+Z%22">Xu Z</searchLink>; Department of Paediatrics, University of Cambridge, Cambridge, UK.; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Pediatrics, Cedars Sinai Guerin Children's, Los Angeles, CA, USA.; Department of Neurosurgery, Cedars Sinai Guerin Children's, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+IL%22">Lu IL</searchLink>; Institute for Regenerative Medicine, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hoi+KK%22">Hoi KK</searchLink>; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wei+M%22">Wei M</searchLink>; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+K%22">Zhu K</searchLink>; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jordan+G%22">Jordan G</searchLink>; Department of Paediatrics, University of Cambridge, Cambridge, UK.; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Tang+XY%22">Tang XY</searchLink>; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Maya+J%22">Gonzalez-Maya J</searchLink>; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mattera+VS%22">Mattera VS</searchLink>; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Panigrahi+SM%22">Panigrahi SM</searchLink>; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kawaguchi+R%22">Kawaguchi R</searchLink>; Department of Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Emery+B%22">Emery B</searchLink>; Jungers Center for Neurosciences Research, Oregon Health & Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Franco+SJ%22">Franco SJ</searchLink>; Department of Pediatrics, University of Colorado Anschutz School of Medicine, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Geschwind+DH%22">Geschwind DH</searchLink>; Department of Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Popko+B%22">Popko B</searchLink>; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Rowitch+DH%22">Rowitch DH</searchLink>; Department of Paediatrics, University of Cambridge, Cambridge, UK. dhr25@cam.ac.uk.; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. dhr25@cam.ac.uk.; Department of Pediatrics, Cedars Sinai Guerin Children's, Los Angeles, CA, USA. dhr25@cam.ac.uk.; Department of Neurosurgery, Cedars Sinai Guerin Children's, Los Angeles, CA, USA. dhr25@cam.ac.uk.; Institute for Regenerative Medicine, University of California, San Francisco, San Francisco, CA, USA. dhr25@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Fancy+SPJ%22">Fancy SPJ</searchLink>; Division of Neuroimmunology and Glial Biology, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. stephen.fancy@ucsf.edu.
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2026 May; Vol. 653 (8115), pp. 819-830. <i>Date of Electronic Publication: </i>2026 Apr 01.
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