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From barrier to bridge: a scoping review on the methods, clinical efficacy, and safety of blood-brain barrier disruption in treating high-grade glioma.

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Title: From barrier to bridge: a scoping review on the methods, clinical efficacy, and safety of blood-brain barrier disruption in treating high-grade glioma.
Authors: Dufault ME; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.; Precision Neuro-Therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA., Akhavan-Sigari A; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.; Precision Neuro-Therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA., Pachón-Londoño MJ; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.; Precision Neuro-Therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA., Olson VA; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.; Precision Neuro-Therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA., Turcotte EL; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.; Precision Neuro-Therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.; Mayo Clinic Alix School of Medicine, Phoenix, AZ, USA., Beniwal AS; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Mayo Clinic Alix School of Medicine, Phoenix, AZ, USA.; Department of Cancer Biology, Mayo Clinic, Phoenix, AZ, USA., Carlson BH; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Mayo Clinic Alix School of Medicine, Phoenix, AZ, USA., Moussalem CK; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.; Precision Neuro-Therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA., Giotta Lucifero A; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.; Precision Neuro-Therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA., Bathini AR; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.; Precision Neuro-Therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA., Bossi Todeschini A; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.; Precision Neuro-Therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA., Porter AB; Department of Neurology, Mayo Clinic, Phoenix, AZ, USA., Mrugala MM; Department of Neurology, Mayo Clinic, Phoenix, AZ, USA., Fortin Ensign S; Department of Cancer Biology, Mayo Clinic, Phoenix, AZ, USA.; Division of Hematology and Oncology, Department of Internal Medicine, Mayo Clinic, Phoenix, AZ, USA., Turkmani AH; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Mayo Clinic Alix School of Medicine, Phoenix, AZ, USA., Krishna C; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Mayo Clinic Alix School of Medicine, Phoenix, AZ, USA., Bendok BR; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA. Bendok.bernard@mayo.edu.; Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA. Bendok.bernard@mayo.edu.; Precision Neuro-Therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA. Bendok.bernard@mayo.edu.; Mayo Clinic Alix School of Medicine, Phoenix, AZ, USA. Bendok.bernard@mayo.edu.; Department of Radiology, Mayo Clinic, Phoenix, AZ, USA. Bendok.bernard@mayo.edu.; Department of Otolaryngology - Head & Neck Surgery, Mayo Clinic, Phoenix, AZ, USA. Bendok.bernard@mayo.edu.; Chair, Department of Neurological Surgery, Mayo Clinic, Phoenix, AZ, USA. Bendok.bernard@mayo.edu.
Source: Journal of neuro-oncology [J Neurooncol] 2026 Apr 01; Vol. 177 (2). Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article; Scoping Review; Review
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 8309335 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7373 (Electronic) Linking ISSN: 0167594X NLM ISO Abbreviation: J Neurooncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 41922786
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: From barrier to bridge: a scoping review on the methods, clinical efficacy, and safety of blood-brain barrier disruption in treating high-grade glioma.
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  Data: <searchLink fieldCode="AU" term="%22Dufault+ME%22">Dufault ME</searchLink>; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.; Precision Neuro-Therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Akhavan-Sigari+A%22">Akhavan-Sigari A</searchLink>; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.; Precision Neuro-Therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Pachón-Londoño+MJ%22">Pachón-Londoño MJ</searchLink>; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.; Precision Neuro-Therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Olson+VA%22">Olson VA</searchLink>; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.; Precision Neuro-Therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Turcotte+EL%22">Turcotte EL</searchLink>; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.; Precision Neuro-Therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.; Mayo Clinic Alix School of Medicine, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Beniwal+AS%22">Beniwal AS</searchLink>; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Mayo Clinic Alix School of Medicine, Phoenix, AZ, USA.; Department of Cancer Biology, Mayo Clinic, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Carlson+BH%22">Carlson BH</searchLink>; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Mayo Clinic Alix School of Medicine, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Moussalem+CK%22">Moussalem CK</searchLink>; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.; Precision Neuro-Therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Giotta+Lucifero+A%22">Giotta Lucifero A</searchLink>; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.; Precision Neuro-Therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Bathini+AR%22">Bathini AR</searchLink>; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.; Precision Neuro-Therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Bossi+Todeschini+A%22">Bossi Todeschini A</searchLink>; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.; Precision Neuro-Therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Porter+AB%22">Porter AB</searchLink>; Department of Neurology, Mayo Clinic, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Mrugala+MM%22">Mrugala MM</searchLink>; Department of Neurology, Mayo Clinic, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Fortin+Ensign+S%22">Fortin Ensign S</searchLink>; Department of Cancer Biology, Mayo Clinic, Phoenix, AZ, USA.; Division of Hematology and Oncology, Department of Internal Medicine, Mayo Clinic, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Turkmani+AH%22">Turkmani AH</searchLink>; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Mayo Clinic Alix School of Medicine, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Krishna+C%22">Krishna C</searchLink>; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA.; Mayo Clinic Alix School of Medicine, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Bendok+BR%22">Bendok BR</searchLink>; Department of Neurological Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA. Bendok.bernard@mayo.edu.; Neurosurgery Simulation and Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA. Bendok.bernard@mayo.edu.; Precision Neuro-Therapeutics Innovation Laboratory, Mayo Clinic, Phoenix, AZ, USA. Bendok.bernard@mayo.edu.; Mayo Clinic Alix School of Medicine, Phoenix, AZ, USA. Bendok.bernard@mayo.edu.; Department of Radiology, Mayo Clinic, Phoenix, AZ, USA. Bendok.bernard@mayo.edu.; Department of Otolaryngology - Head & Neck Surgery, Mayo Clinic, Phoenix, AZ, USA. Bendok.bernard@mayo.edu.; Chair, Department of Neurological Surgery, Mayo Clinic, Phoenix, AZ, USA. Bendok.bernard@mayo.edu.
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  Data: <searchLink fieldCode="JN" term="%228309335%22">Journal of neuro-oncology</searchLink> [J Neurooncol] 2026 Apr 01; Vol. 177 (2). <i>Date of Electronic Publication: </i>2026 Apr 01.
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