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Subamnex Ameliorates Hypoxia-Induced Pulmonary Arterial Hypertension through Modulation of the STAT3/p-STAT3 Pathway.

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Title: Subamnex Ameliorates Hypoxia-Induced Pulmonary Arterial Hypertension through Modulation of the STAT3/p-STAT3 Pathway.
Authors: Ge RX; Pharmacy Department of Huaihe Hospital, Henan University, Kaifeng 475000, China.; 986 Hospital, Xijing Hospital, The Fourth Military Medical University, Xi'an 710000, Shaanxi, China., Shi JZ; Pharmacy Department of Huaihe Hospital, Henan University, Kaifeng 475000, China.; School of Pharmacy, Henan University, Kaifeng 475004, China., Guo BH; School of Pharmacy, Henan University, Kaifeng 475004, China., Zhang MJ; School of Pharmacy, Henan University, Kaifeng 475004, China., Zeng M; School of Pharmacy, Henan University, Kaifeng 475004, China., An XR; School of Pharmacy, Henan University, Kaifeng 475004, China., Ye JS; School of Pharmacy, Henan University, Kaifeng 475004, China., Cheng G; School of Pharmacy, Henan University, Kaifeng 475004, China., Fan X; School of Pharmacy, Henan University, Kaifeng 475004, China., Wang MW; School of Pharmacy, Henan University, Kaifeng 475004, China., Zhou YF; School of Pharmacy, Henan University, Kaifeng 475004, China., Li X; School of Pharmacy, Henan University, Kaifeng 475004, China., Pang XB; School of Pharmacy, Henan University, Kaifeng 475004, China., Xie XM; School of Pharmacy, Henan University, Kaifeng 475004, China., Zhang HD; Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Cardiovascular Institute, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China., Zhao LL; School of Pharmacy, Henan University, Kaifeng 475004, China., He YY; Pharmacy Department of Huaihe Hospital, Henan University, Kaifeng 475000, China.; School of Pharmacy, Henan University, Kaifeng 475004, China., Kou JJ; Pharmacy Department of Huaihe Hospital, Henan University, Kaifeng 475000, China.; School of Pharmacy, Henan University, Kaifeng 475004, China., Ma J; School of Pharmacy, Huaihe Hospital of Henan University, The Zhongzhou Laboratory for Integrative Biology, State Key Laboratory of Antiviral Drugs, Institute of Chemical Biology, Henan Province Engineering Research Center of High Value Utilization to Natural Medical Resource in Yellow River Basin, Henan University, Kaifeng 475004, Henan, China., Yan Y; Heart Center, Shanghai Institute of Pediatric Congenital Heart Disease and Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Apr 23; Vol. 69 (8), pp. 8790-8806. Date of Electronic Publication: 2026 Apr 02.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Subamnex Ameliorates Hypoxia-Induced Pulmonary Arterial Hypertension through Modulation of the STAT3/p-STAT3 Pathway.
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  Data: <searchLink fieldCode="AU" term="%22Ge+RX%22">Ge RX</searchLink>; Pharmacy Department of Huaihe Hospital, Henan University, Kaifeng 475000, China.; 986 Hospital, Xijing Hospital, The Fourth Military Medical University, Xi'an 710000, Shaanxi, China.<br /><searchLink fieldCode="AU" term="%22Shi+JZ%22">Shi JZ</searchLink>; Pharmacy Department of Huaihe Hospital, Henan University, Kaifeng 475000, China.; School of Pharmacy, Henan University, Kaifeng 475004, China.<br /><searchLink fieldCode="AU" term="%22Guo+BH%22">Guo BH</searchLink>; School of Pharmacy, Henan University, Kaifeng 475004, China.<br /><searchLink fieldCode="AU" term="%22Zhang+MJ%22">Zhang MJ</searchLink>; School of Pharmacy, Henan University, Kaifeng 475004, China.<br /><searchLink fieldCode="AU" term="%22Zeng+M%22">Zeng M</searchLink>; School of Pharmacy, Henan University, Kaifeng 475004, China.<br /><searchLink fieldCode="AU" term="%22An+XR%22">An XR</searchLink>; School of Pharmacy, Henan University, Kaifeng 475004, China.<br /><searchLink fieldCode="AU" term="%22Ye+JS%22">Ye JS</searchLink>; School of Pharmacy, Henan University, Kaifeng 475004, China.<br /><searchLink fieldCode="AU" term="%22Cheng+G%22">Cheng G</searchLink>; School of Pharmacy, Henan University, Kaifeng 475004, China.<br /><searchLink fieldCode="AU" term="%22Fan+X%22">Fan X</searchLink>; School of Pharmacy, Henan University, Kaifeng 475004, China.<br /><searchLink fieldCode="AU" term="%22Wang+MW%22">Wang MW</searchLink>; School of Pharmacy, Henan University, Kaifeng 475004, China.<br /><searchLink fieldCode="AU" term="%22Zhou+YF%22">Zhou YF</searchLink>; School of Pharmacy, Henan University, Kaifeng 475004, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; School of Pharmacy, Henan University, Kaifeng 475004, China.<br /><searchLink fieldCode="AU" term="%22Pang+XB%22">Pang XB</searchLink>; School of Pharmacy, Henan University, Kaifeng 475004, China.<br /><searchLink fieldCode="AU" term="%22Xie+XM%22">Xie XM</searchLink>; School of Pharmacy, Henan University, Kaifeng 475004, China.<br /><searchLink fieldCode="AU" term="%22Zhang+HD%22">Zhang HD</searchLink>; Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Cardiovascular Institute, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China.<br /><searchLink fieldCode="AU" term="%22Zhao+LL%22">Zhao LL</searchLink>; School of Pharmacy, Henan University, Kaifeng 475004, China.<br /><searchLink fieldCode="AU" term="%22He+YY%22">He YY</searchLink>; Pharmacy Department of Huaihe Hospital, Henan University, Kaifeng 475000, China.; School of Pharmacy, Henan University, Kaifeng 475004, China.<br /><searchLink fieldCode="AU" term="%22Kou+JJ%22">Kou JJ</searchLink>; Pharmacy Department of Huaihe Hospital, Henan University, Kaifeng 475000, China.; School of Pharmacy, Henan University, Kaifeng 475004, China.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; School of Pharmacy, Huaihe Hospital of Henan University, The Zhongzhou Laboratory for Integrative Biology, State Key Laboratory of Antiviral Drugs, Institute of Chemical Biology, Henan Province Engineering Research Center of High Value Utilization to Natural Medical Resource in Yellow River Basin, Henan University, Kaifeng 475004, Henan, China.<br /><searchLink fieldCode="AU" term="%22Yan+Y%22">Yan Y</searchLink>; Heart Center, Shanghai Institute of Pediatric Congenital Heart Disease and Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2026 Apr 23; Vol. 69 (8), pp. 8790-8806. <i>Date of Electronic Publication: </i>2026 Apr 02.
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        Value: 10.1021/acs.jmedchem.5c02221
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              Text: 2026 Apr 23
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