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Peripheral blood UBA1 variant burden predicts poor outcomes in VEXAS syndrome: a nationwide prospective study.

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Title: Peripheral blood UBA1 variant burden predicts poor outcomes in VEXAS syndrome: a nationwide prospective study.
Authors: Kirino Y; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan. Electronic address: kirino@yokohama-cu.ac.jp., Maeda A; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Higashitani K; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Horita N; Chemotherapy Center, Yokohama City University Hospital, Yokohama, Japan., Asano T; Department of Rheumatology, Fukushima Medical University School of Medicine, Fukushima, Japan., Migita K; Department of Rheumatology, Fukushima Medical University School of Medicine, Fukushima, Japan., Motomura Y; Division of Rheumatology, Department of Internal Medicine, Kameda Medical Center, Kamogawa, Japan., Rokutanda R; Division of Rheumatology, Department of Internal Medicine, Kameda Medical Center, Kamogawa, Japan., Kobayashi D; Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Tamura M; Department of Diabetes, Endocrinology and Clinical Immunology, Hyogo Medical University, Nishinomiya, Japan., Kanazawa N; Department of Dermatology, Hyogo Medical University, Nishinomiya, Japan., Furuhashi K; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan., Kondo Y; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan., Nagahata K; Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan., Takahashi H; Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan., Kobayashi H; Department of Rheumatology, Tokyo Medical University Hachioji Medical Center, Hachioji, Japan., Yao S; Department of Internal Medicine, Osaka City General Hospital, Osaka, Japan., Yamagami K; Department of Internal Medicine, Osaka City General Hospital, Osaka, Japan., Uchino K; Division of Hematology, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan., Hidaka Y; Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan., Ida H; Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan., Kishida D; Department of Medicine (Neurology & Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan., Sato T; Department of Rheumatology, Shimane University Faculty of Medicine, Izumo, Japan., Ichinose K; Department of Rheumatology, Shimane University Faculty of Medicine, Izumo, Japan., Miyamae T; Department of Pediatric Rheumatology, Tokyo Women's Medical University Hospital, Tokyo, Japan., Tsujimoto K; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan., Inoue Y; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine, Hokkaido University, Sapporo, Japan., Fujieda Y; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine, Hokkaido University, Sapporo, Japan., Mishima K; Center for Rheumatic Diseases, Matsuyama Red Cross Hospital, Matsuyama, Japan., Tsuji T; Center for Rheumatic Diseases, Matsuyama Red Cross Hospital, Matsuyama, Japan., Tanaka K; Department of Respiratory Medicine, Fujieda Municipal General Hospital, Fujieda, Japan., Noda H; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan., Isogai S; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan., Miyoshi Y; Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Fuchū, Japan., Yokogawa N; Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Fuchū, Japan., Ota S; Department of Gastroenterology, Hematology and Clinical Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Sakuraba H; Department of Gastroenterology, Hematology and Clinical Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Nishi J; Division of Dermatology, Faculty of Medicine, Saga University, Saga, Japan., Inoue T; Division of Dermatology, Faculty of Medicine, Saga University, Saga, Japan., Muraoka S; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan., Nanki T; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan., Shimizu T; Departments of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Koga T; Departments of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Inaba Y; Department of Dermatology, Wakayama Medical University, Wakayama, Japan., Matsubara M; Department of General Medicine, Nara Medical University, Kashihara, Japan., Yoshimoto K; Department of General Medicine, Nara Medical University, Kashihara, Japan., Hasegawa A; Department of Rheumatology, Dokkyo Medical University, Mibu, Japan., Ikeda K; Department of Rheumatology, Dokkyo Medical University, Mibu, Japan., Motohashi R; Department of Rheumatology and Nephrology, Japanese Red Cross Maebashi Hospital, Maebashi, Japan., Takeuchi Y; Department of Rheumatology and Nephrology, Japanese Red Cross Maebashi Hospital, Maebashi, Japan., Shiratsuchi M; Department of Hematology, Iizuka Hospital, Iizuka, Japan., Moriyama M; Division of Rheumatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan., Noda K; Division of Rheumatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan., Saito S; Department of Rheumatology, Yokohama City Minato Red Cross Hospital, Yokohama, Japan., Hagiyama H; Department of Rheumatology, Yokohama City Minato Red Cross Hospital, Yokohama, Japan., Honda T; Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan., Kageyama R; Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan., Nakatani N; Department of Hematology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Japan., Goto T; Department of Hematology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Japan., Kishimoto M; Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Mitaka, Japan., Watanabe T; Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Yamaguchi Y; Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Nishikomori R; Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Japan., Ohara O; Department of Applied Genomics, Kazusa DNA Research Institute, Kisarazu, Japan., Ban T; Department of Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Tamura T; Department of Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Nakajima H; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Source: Annals of the rheumatic diseases [Ann Rheum Dis] 2026 Apr 01. Date of Electronic Publication: 2026 Apr 01.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2060 (Electronic) Linking ISSN: 00034967 NLM ISO Abbreviation: Ann Rheum Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Peripheral blood UBA1 variant burden predicts poor outcomes in VEXAS syndrome: a nationwide prospective study.
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  Data: <searchLink fieldCode="AU" term="%22Kirino+Y%22">Kirino Y</searchLink>; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan. 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Division of Rheumatology, Department of Internal Medicine, Kameda Medical Center, Kamogawa, Japan.<br /><searchLink fieldCode="AU" term="%22Rokutanda+R%22">Rokutanda R</searchLink>; Division of Rheumatology, Department of Internal Medicine, Kameda Medical Center, Kamogawa, Japan.<br /><searchLink fieldCode="AU" term="%22Kobayashi+D%22">Kobayashi D</searchLink>; Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.<br /><searchLink fieldCode="AU" term="%22Tamura+M%22">Tamura M</searchLink>; Department of Diabetes, Endocrinology and Clinical Immunology, Hyogo Medical University, Nishinomiya, Japan.<br /><searchLink fieldCode="AU" term="%22Kanazawa+N%22">Kanazawa N</searchLink>; Department of Dermatology, Hyogo Medical University, Nishinomiya, Japan.<br /><searchLink fieldCode="AU" term="%22Furuhashi+K%22">Furuhashi K</searchLink>; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kondo+Y%22">Kondo Y</searchLink>; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nagahata+K%22">Nagahata K</searchLink>; Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Takahashi+H%22">Takahashi H</searchLink>; Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Kobayashi+H%22">Kobayashi H</searchLink>; Department of Rheumatology, Tokyo Medical University Hachioji Medical Center, Hachioji, Japan.<br /><searchLink fieldCode="AU" term="%22Yao+S%22">Yao S</searchLink>; Department of Internal Medicine, Osaka City General Hospital, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Yamagami+K%22">Yamagami K</searchLink>; Department of Internal Medicine, Osaka City General Hospital, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Uchino+K%22">Uchino K</searchLink>; Division of Hematology, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan.<br /><searchLink fieldCode="AU" term="%22Hidaka+Y%22">Hidaka Y</searchLink>; Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan.<br /><searchLink fieldCode="AU" term="%22Ida+H%22">Ida H</searchLink>; Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan.<br /><searchLink fieldCode="AU" term="%22Kishida+D%22">Kishida D</searchLink>; Department of Medicine (Neurology & Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan.<br /><searchLink fieldCode="AU" term="%22Sato+T%22">Sato T</searchLink>; Department of Rheumatology, Shimane University Faculty of Medicine, Izumo, Japan.<br /><searchLink fieldCode="AU" term="%22Ichinose+K%22">Ichinose K</searchLink>; Department of Rheumatology, Shimane University Faculty of Medicine, Izumo, Japan.<br /><searchLink fieldCode="AU" term="%22Miyamae+T%22">Miyamae T</searchLink>; Department of Pediatric Rheumatology, Tokyo Women's Medical University Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Tsujimoto+K%22">Tsujimoto K</searchLink>; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Inoue+Y%22">Inoue Y</searchLink>; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Fujieda+Y%22">Fujieda Y</searchLink>; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine, Hokkaido University, Sapporo, Japan.<br /><searchLink fieldCode="AU" term="%22Mishima+K%22">Mishima K</searchLink>; Center for Rheumatic Diseases, Matsuyama Red Cross Hospital, Matsuyama, Japan.<br /><searchLink fieldCode="AU" term="%22Tsuji+T%22">Tsuji T</searchLink>; Center for Rheumatic Diseases, Matsuyama Red Cross Hospital, Matsuyama, Japan.<br /><searchLink fieldCode="AU" term="%22Tanaka+K%22">Tanaka K</searchLink>; Department of Respiratory Medicine, Fujieda Municipal General Hospital, Fujieda, Japan.<br /><searchLink fieldCode="AU" term="%22Noda+H%22">Noda H</searchLink>; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Isogai+S%22">Isogai S</searchLink>; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Miyoshi+Y%22">Miyoshi Y</searchLink>; Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Fuchū, Japan.<br /><searchLink fieldCode="AU" term="%22Yokogawa+N%22">Yokogawa N</searchLink>; Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Fuchū, Japan.<br /><searchLink fieldCode="AU" term="%22Ota+S%22">Ota S</searchLink>; Department of Gastroenterology, Hematology and Clinical Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.<br /><searchLink fieldCode="AU" term="%22Sakuraba+H%22">Sakuraba H</searchLink>; Department of Gastroenterology, Hematology and Clinical Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.<br /><searchLink fieldCode="AU" term="%22Nishi+J%22">Nishi J</searchLink>; Division of Dermatology, Faculty of Medicine, Saga University, Saga, Japan.<br /><searchLink fieldCode="AU" term="%22Inoue+T%22">Inoue T</searchLink>; Division of Dermatology, Faculty of Medicine, Saga University, Saga, Japan.<br /><searchLink fieldCode="AU" term="%22Muraoka+S%22">Muraoka S</searchLink>; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nanki+T%22">Nanki T</searchLink>; Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Shimizu+T%22">Shimizu T</searchLink>; Departments of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Koga+T%22">Koga T</searchLink>; 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Department of Rheumatology and Nephrology, Japanese Red Cross Maebashi Hospital, Maebashi, Japan.<br /><searchLink fieldCode="AU" term="%22Shiratsuchi+M%22">Shiratsuchi M</searchLink>; Department of Hematology, Iizuka Hospital, Iizuka, Japan.<br /><searchLink fieldCode="AU" term="%22Moriyama+M%22">Moriyama M</searchLink>; Division of Rheumatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Noda+K%22">Noda K</searchLink>; Division of Rheumatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Saito+S%22">Saito S</searchLink>; Department of Rheumatology, Yokohama City Minato Red Cross Hospital, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Hagiyama+H%22">Hagiyama H</searchLink>; Department of Rheumatology, Yokohama City Minato Red Cross Hospital, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Honda+T%22">Honda T</searchLink>; Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.<br /><searchLink fieldCode="AU" term="%22Kageyama+R%22">Kageyama R</searchLink>; Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.<br /><searchLink fieldCode="AU" term="%22Nakatani+N%22">Nakatani N</searchLink>; Department of Hematology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Goto+T%22">Goto T</searchLink>; Department of Hematology, Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Kishimoto+M%22">Kishimoto M</searchLink>; Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Mitaka, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+T%22">Watanabe T</searchLink>; Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Yamaguchi+Y%22">Yamaguchi Y</searchLink>; 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            NameFull: Nanki T
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            NameFull: Shimizu T
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            NameFull: Koga T
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            NameFull: Yoshimoto K
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      – PersonEntity:
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            NameFull: Kageyama R
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          Dates:
            – D: 01
              M: 04
              Text: 2026 Apr 01
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1468-2060
          Titles:
            – TitleFull: Annals of the rheumatic diseases
              Type: main
ResultId 1