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ADAR2 induces the differentiation of osteosarcoma cells by editing activity on IGFBP7: new implications for therapy.

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Title: ADAR2 induces the differentiation of osteosarcoma cells by editing activity on IGFBP7: new implications for therapy.
Authors: Rossi M; Bone Physiopathology Research Unit, Translational Pediatric and Clinical Genetic Research Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Scotto di Carlo F; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso', National Research Council of Italy, Naples, Italy., Di Gregorio J; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Russo S; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso', National Research Council of Italy, Naples, Italy., Di Giuseppe L; Bone Physiopathology Research Unit, Translational Pediatric and Clinical Genetic Research Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Battafarano G; Bone Physiopathology Research Unit, Translational Pediatric and Clinical Genetic Research Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Terreri S; Bone Physiopathology Research Unit, Translational Pediatric and Clinical Genetic Research Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Pagliarosi O; Department of Medical and Cardiovascular Sciences, Sapienza University, Rome, Italy., Silvestris DA; Unit of Genetic and Epigenetics of pediatric tumors, Oncohaematology Research Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Corona M; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso', National Research Council of Italy, Naples, Italy., Barra A; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso', National Research Council of Italy, Naples, Italy., Pezzullo M; Research Laboratories, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., De Stefanis C; Research Laboratories, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Pelle S; 'Polo Sanitario San Feliciano-Villa Aurora' Clinic, Rome, Italy., Costici PF; Department of General Surgery and Medical Surgical Specialties, Orthopedics Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Palidoro, Italy., Minisola S; Department of Medical and Cardiovascular Sciences, Sapienza University, Rome, Italy., Pepe J; Department of Medical and Cardiovascular Sciences, Sapienza University, Rome, Italy., Locatelli F; Unit of Genetic and Epigenetics of pediatric tumors, Oncohaematology Research Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.; Department of Life Sciences and Public Health, Catholic University of the Sacred Heart, Rome, Italy., Gianfrancesco F; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso', National Research Council of Italy, Naples, Italy., Gallo A; Unit of Genetic and Epigenetics of pediatric tumors, Oncohaematology Research Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. angela.gallo@opbg.net., Del Fattore A; Bone Physiopathology Research Unit, Translational Pediatric and Clinical Genetic Research Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. andrea.delfattore@opbg.net.
Source: Bone research [Bone Res] 2026 Apr 03; Vol. 14 (1). Date of Electronic Publication: 2026 Apr 03.
Publication Type: Journal Article
Journal Info: Publisher: West China School of Stomatology, Sichuan University Country of Publication: China NLM ID: 101608652 Publication Model: Electronic Cited Medium: Print ISSN: 2095-4700 (Print) Linking ISSN: 20954700 NLM ISO Abbreviation: Bone Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: ADAR2 induces the differentiation of osteosarcoma cells by editing activity on IGFBP7: new implications for therapy.
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  Data: <searchLink fieldCode="AU" term="%22Rossi+M%22">Rossi M</searchLink>; Bone Physiopathology Research Unit, Translational Pediatric and Clinical Genetic Research Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Scotto+di+Carlo+F%22">Scotto di Carlo F</searchLink>; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso', National Research Council of Italy, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Gregorio+J%22">Di Gregorio J</searchLink>; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.<br /><searchLink fieldCode="AU" term="%22Russo+S%22">Russo S</searchLink>; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso', National Research Council of Italy, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Giuseppe+L%22">Di Giuseppe L</searchLink>; Bone Physiopathology Research Unit, Translational Pediatric and Clinical Genetic Research Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Battafarano+G%22">Battafarano G</searchLink>; Bone Physiopathology Research Unit, Translational Pediatric and Clinical Genetic Research Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Terreri+S%22">Terreri S</searchLink>; Bone Physiopathology Research Unit, Translational Pediatric and Clinical Genetic Research Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Pagliarosi+O%22">Pagliarosi O</searchLink>; Department of Medical and Cardiovascular Sciences, Sapienza University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Silvestris+DA%22">Silvestris DA</searchLink>; Unit of Genetic and Epigenetics of pediatric tumors, Oncohaematology Research Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Corona+M%22">Corona M</searchLink>; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso', National Research Council of Italy, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Barra+A%22">Barra A</searchLink>; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso', National Research Council of Italy, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Pezzullo+M%22">Pezzullo M</searchLink>; Research Laboratories, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22De+Stefanis+C%22">De Stefanis C</searchLink>; Research Laboratories, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Pelle+S%22">Pelle S</searchLink>; 'Polo Sanitario San Feliciano-Villa Aurora' Clinic, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Costici+PF%22">Costici PF</searchLink>; Department of General Surgery and Medical Surgical Specialties, Orthopedics Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Palidoro, Italy.<br /><searchLink fieldCode="AU" term="%22Minisola+S%22">Minisola S</searchLink>; Department of Medical and Cardiovascular Sciences, Sapienza University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Pepe+J%22">Pepe J</searchLink>; Department of Medical and Cardiovascular Sciences, Sapienza University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Locatelli+F%22">Locatelli F</searchLink>; Unit of Genetic and Epigenetics of pediatric tumors, Oncohaematology Research Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.; Department of Life Sciences and Public Health, Catholic University of the Sacred Heart, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Gianfrancesco+F%22">Gianfrancesco F</searchLink>; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso', National Research Council of Italy, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Gallo+A%22">Gallo A</searchLink>; Unit of Genetic and Epigenetics of pediatric tumors, Oncohaematology Research Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. angela.gallo@opbg.net.<br /><searchLink fieldCode="AU" term="%22Del+Fattore+A%22">Del Fattore A</searchLink>; Bone Physiopathology Research Unit, Translational Pediatric and Clinical Genetic Research Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. andrea.delfattore@opbg.net.
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  Data: <searchLink fieldCode="JN" term="%22101608652%22">Bone research</searchLink> [Bone Res] 2026 Apr 03; Vol. 14 (1). <i>Date of Electronic Publication: </i>2026 Apr 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22West+China+School+of+Stomatology%2C+Sichuan+University%22">West China School of Stomatology, Sichuan University </searchLink><i>Country of Publication: </i>China <i>NLM ID: </i>101608652 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2095-4700 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220954700%22">20954700 </searchLink><i>NLM ISO Abbreviation: </i>Bone Res <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41413-026-00516-6
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        Text: English
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              Text: 2026 Apr 03
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