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Descending inhibitory rostral ventromedial medulla neurons cause widespread antinociception and contribute to the pain-inhibits-pain phenomenon.

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Title: Descending inhibitory rostral ventromedial medulla neurons cause widespread antinociception and contribute to the pain-inhibits-pain phenomenon.
Authors: Ganley RP; Institute for Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.; Molecular Genetics Section, National Institute of Dentofacial and Craniofacial Research, NIH, Bethesda, MD, USA., Sousa M; Institute for Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.; Neuroscience Center Zurich (ZNZ), University of Zürich, Zürich, Switzerland., Ji G; Department of Pharmacology & Neuroscience, Texas Tech University Health Sciences Center, Lubbock, TX, USA., Ranucci M; Institute for Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.; Neuroscience Center Zurich (ZNZ), University of Zürich, Zürich, Switzerland., Beccarini C; Institute for Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.; Neuroscience Center Zurich (ZNZ), University of Zürich, Zürich, Switzerland., Werder K; Institute for Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland., Pietrafesa F; Institute for Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.; Neuroscience Center Zurich (ZNZ), University of Zürich, Zürich, Switzerland., d'Aquin S; Institute for Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland., Akyüz T; Institute of Pharmaceutical Sciences, ETH Zürich, Zürich, Switzerland., Hubli M; Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland., Schweinhardt P; Department of Chiropractic Medicine, Balgrist University Hospital, University of Zurich, Zurich, Switzerland., Neugebauer V; Department of Pharmacology & Neuroscience, Texas Tech University Health Sciences Center, Lubbock, TX, USA., Hoon MA; Molecular Genetics Section, National Institute of Dentofacial and Craniofacial Research, NIH, Bethesda, MD, USA., Wildner H; Institute for Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland., Zeilhofer HU; Institute for Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland. zeilhofer@pharma.uzh.ch.; Neuroscience Center Zurich (ZNZ), University of Zürich, Zürich, Switzerland. zeilhofer@pharma.uzh.ch.; Institute of Pharmaceutical Sciences, ETH Zürich, Zürich, Switzerland. zeilhofer@pharma.uzh.ch.
Source: Nature communications [Nat Commun] 2026 Apr 02; Vol. 17 (1). Date of Electronic Publication: 2026 Apr 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Descending inhibitory rostral ventromedial medulla neurons cause widespread antinociception and contribute to the pain-inhibits-pain phenomenon.
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  Data: <searchLink fieldCode="AU" term="%22Ganley+RP%22">Ganley RP</searchLink>; Institute for Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.; Molecular Genetics Section, National Institute of Dentofacial and Craniofacial Research, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sousa+M%22">Sousa M</searchLink>; Institute for Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.; Neuroscience Center Zurich (ZNZ), University of Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ji+G%22">Ji G</searchLink>; Department of Pharmacology & Neuroscience, Texas Tech University Health Sciences Center, Lubbock, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ranucci+M%22">Ranucci M</searchLink>; Institute for Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.; Neuroscience Center Zurich (ZNZ), University of Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Beccarini+C%22">Beccarini C</searchLink>; Institute for Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.; Neuroscience Center Zurich (ZNZ), University of Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Werder+K%22">Werder K</searchLink>; Institute for Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pietrafesa+F%22">Pietrafesa F</searchLink>; Institute for Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.; Neuroscience Center Zurich (ZNZ), University of Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22d'Aquin+S%22">d'Aquin S</searchLink>; Institute for Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Akyüz+T%22">Akyüz T</searchLink>; Institute of Pharmaceutical Sciences, ETH Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hubli+M%22">Hubli M</searchLink>; Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schweinhardt+P%22">Schweinhardt P</searchLink>; Department of Chiropractic Medicine, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Neugebauer+V%22">Neugebauer V</searchLink>; Department of Pharmacology & Neuroscience, Texas Tech University Health Sciences Center, Lubbock, TX, USA.<br /><searchLink fieldCode="AU" term="%22Hoon+MA%22">Hoon MA</searchLink>; Molecular Genetics Section, National Institute of Dentofacial and Craniofacial Research, NIH, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wildner+H%22">Wildner H</searchLink>; Institute for Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zeilhofer+HU%22">Zeilhofer HU</searchLink>; Institute for Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland. zeilhofer@pharma.uzh.ch.; Neuroscience Center Zurich (ZNZ), University of Zürich, Zürich, Switzerland. zeilhofer@pharma.uzh.ch.; Institute of Pharmaceutical Sciences, ETH Zürich, Zürich, Switzerland. zeilhofer@pharma.uzh.ch.
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