Descending inhibitory rostral ventromedial medulla neurons cause widespread antinociception and contribute to the pain-inhibits-pain phenomenon. - Ganley RP; Sousa M; Ji G; Ranucci M; Beccarini C; Werder K; Pietrafesa F; d'Aquin S; Akyüz T; Hubli M; Schweinhardt P; Neugebauer V; et al. (Nature communications, 2026)