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AXL-SHC1 signaling axis mediates adaptive resistance to HER2-targeted tyrosine kinase inhibitors in HER2-aberrant lung and gastric cancers.

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Title: AXL-SHC1 signaling axis mediates adaptive resistance to HER2-targeted tyrosine kinase inhibitors in HER2-aberrant lung and gastric cancers.
Authors: Ishida M; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan., Yamada T; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan. tayamada@koto.kpu-m.ac.jp., Katayama Y; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan., Kawachi H; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan., Sawada R; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan., Nakamura R; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan., Hirai S; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan., Matsui Y; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan., Morimoto K; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan., Onoi K; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan., Nakamura-Sasada A; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan., Horinaka M; Department of Drug Discovery Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan., Sakai T; Department of Drug Discovery Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan., Sakakida T; Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Doi T; Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Yasumoto K; Department of Medical Oncology, Kanazawa Medical University, Uchinada, Ishikawa, Japan., Goto Y; Department of Respiratory Medicine, Fujita Health University School of Medicine, Toyoake, Aichi, Japan., Furuya N; Department of Respiratory Medicine, St. Marianna University School of Medicine, Kawasaki, Japan., Taniguchi H; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Ogino H; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan., Takayuki N; Department of Respiratory Medicine, Fukuchiyama City Hospital, Kyoto, Japan., Chihara Y; Department of Respiratory Medicine, Uji Tokushukai Medical Center, Uji, Kyoto, Japan., Fukuda K; Division of Innovative Cancer Control Research, Cancer Research Institute, Kanazawa University, Kanazawa, Japan., Taniguchi H; Division of Innovative Cancer Control Research, Cancer Research Institute, Kanazawa University, Kanazawa, Japan., Uehara H; Department of Diagnostic Pathology, Tokushima University Hospital, Tokushima, Japan., Yano S; Division of Innovative Cancer Control Research, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.; Department of Respiratory medicine, Kanazawa Graduate School of Medical Sciences, Kanazawa, Japan., Tokuda S; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan., Takayama K; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan.
Source: NPJ precision oncology [NPJ Precis Oncol] 2026 Apr 02; Vol. 10 (1). Date of Electronic Publication: 2026 Apr 02.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: AXL-SHC1 signaling axis mediates adaptive resistance to HER2-targeted tyrosine kinase inhibitors in HER2-aberrant lung and gastric cancers.
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  Data: <searchLink fieldCode="AU" term="%22Ishida+M%22">Ishida M</searchLink>; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Yamada+T%22">Yamada T</searchLink>; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan. tayamada@koto.kpu-m.ac.jp.<br /><searchLink fieldCode="AU" term="%22Katayama+Y%22">Katayama Y</searchLink>; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kawachi+H%22">Kawachi H</searchLink>; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Sawada+R%22">Sawada R</searchLink>; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Nakamura+R%22">Nakamura R</searchLink>; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Hirai+S%22">Hirai S</searchLink>; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Matsui+Y%22">Matsui Y</searchLink>; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Morimoto+K%22">Morimoto K</searchLink>; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Onoi+K%22">Onoi K</searchLink>; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Nakamura-Sasada+A%22">Nakamura-Sasada A</searchLink>; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Horinaka+M%22">Horinaka M</searchLink>; Department of Drug Discovery Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Sakai+T%22">Sakai T</searchLink>; Department of Drug Discovery Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Sakakida+T%22">Sakakida T</searchLink>; Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Doi+T%22">Doi T</searchLink>; Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Yasumoto+K%22">Yasumoto K</searchLink>; Department of Medical Oncology, Kanazawa Medical University, Uchinada, Ishikawa, Japan.<br /><searchLink fieldCode="AU" term="%22Goto+Y%22">Goto Y</searchLink>; Department of Respiratory Medicine, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.<br /><searchLink fieldCode="AU" term="%22Furuya+N%22">Furuya N</searchLink>; Department of Respiratory Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Taniguchi+H%22">Taniguchi H</searchLink>; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Ogino+H%22">Ogino H</searchLink>; Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.<br /><searchLink fieldCode="AU" term="%22Takayuki+N%22">Takayuki N</searchLink>; Department of Respiratory Medicine, Fukuchiyama City Hospital, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Chihara+Y%22">Chihara Y</searchLink>; Department of Respiratory Medicine, Uji Tokushukai Medical Center, Uji, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Fukuda+K%22">Fukuda K</searchLink>; Division of Innovative Cancer Control Research, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.<br /><searchLink fieldCode="AU" term="%22Taniguchi+H%22">Taniguchi H</searchLink>; Division of Innovative Cancer Control Research, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.<br /><searchLink fieldCode="AU" term="%22Uehara+H%22">Uehara H</searchLink>; Department of Diagnostic Pathology, Tokushima University Hospital, Tokushima, Japan.<br /><searchLink fieldCode="AU" term="%22Yano+S%22">Yano S</searchLink>; Division of Innovative Cancer Control Research, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.; Department of Respiratory medicine, Kanazawa Graduate School of Medical Sciences, Kanazawa, Japan.<br /><searchLink fieldCode="AU" term="%22Tokuda+S%22">Tokuda S</searchLink>; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Takayama+K%22">Takayama K</searchLink>; Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, Japan.
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  Data: <searchLink fieldCode="JN" term="%22101708166%22">NPJ precision oncology</searchLink> [NPJ Precis Oncol] 2026 Apr 02; Vol. 10 (1). <i>Date of Electronic Publication: </i>2026 Apr 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Nature%22">Springer Nature </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101708166 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2397-768X (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222397768X%22">2397768X </searchLink><i>NLM ISO Abbreviation: </i>NPJ Precis Oncol <i>Subsets: </i>PubMed not MEDLINE
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