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Delivering cytokine mRNA to secondary lymphoid organs for robust cancer immunotherapy.

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Title: Delivering cytokine mRNA to secondary lymphoid organs for robust cancer immunotherapy.
Authors: Anbergen T; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; These authors contributed equally: T.A., Y.v.E., S.R.J.H., M.M.A.H., J.D., van Elsas Y; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; These authors contributed equally: T.A., Y.v.E., S.R.J.H., M.M.A.H., J.D., Hofstraat SRJ; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.; These authors contributed equally: T.A., Y.v.E., S.R.J.H., M.M.A.H., J.D., Hendrikx MMA; Biotrip B.V., Eindhoven, the Netherlands.; These authors contributed equally: T.A., Y.v.E., S.R.J.H., M.M.A.H., J.D., Deckers J; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; These authors contributed equally: T.A., Y.v.E., S.R.J.H., M.M.A.H., J.D., Versteeg I; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Ros GWB; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Kapteijns MHAP; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands., Bartelet BM; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Zwolsman R; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands., Trines MM; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands., Hoorn D; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands., Bex S; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., van Houten P; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Ziogas A; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Grao-Roldán C; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., Davighi GM; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wang W; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Soultanidis G; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Farid AS; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Lee YH; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Voeten N; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.; Department of Obstetrics and Gynecology, Catharina Cancer Institute, Catharina Hospital, Eindhoven, the Netherlands., Piek JMJ; Department of Obstetrics and Gynecology, Catharina Cancer Institute, Catharina Hospital, Eindhoven, the Netherlands., Franssen GM; Department of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands., Heskamp S; Department of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands., Janssen HM; SyMO-Chem B.V., Eindhoven, the Netherlands., Fransen PM; SyMO-Chem B.V., Eindhoven, the Netherlands., Langouo-Fontsa MD; Molecular Immunology Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium., Garavello ACM; Cancer Ecosystems and Metastasis laboratory, Université libre de Bruxelles, Institut Jules Bordet, Brussels, Belgium., Karras P; Cancer Ecosystems and Metastasis laboratory, Université libre de Bruxelles, Institut Jules Bordet, Brussels, Belgium., Netea-Maier RT; Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands., Pérez-Medina C; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., Fayad ZA; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., van Leent MMT; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Teunissen AJP; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Rashidian M; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Kluza E; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands., Toner YC; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Priem B; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Kreijtz JHCM; Biotrip B.V., Eindhoven, the Netherlands., Beldman TJ; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands., Netea MG; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany., van der Meel R; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands., Mulder WJM; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
Source: Research square [Res Sq] 2026 Mar 25. Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
  Label: Title
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  Data: Delivering cytokine mRNA to secondary lymphoid organs for robust cancer immunotherapy.
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  Data: <searchLink fieldCode="AU" term="%22Anbergen+T%22">Anbergen T</searchLink>; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; These authors contributed equally: T.A., Y.v.E., S.R.J.H., M.M.A.H., J.D.<br /><searchLink fieldCode="AU" term="%22van+Elsas+Y%22">van Elsas Y</searchLink>; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; These authors contributed equally: T.A., Y.v.E., S.R.J.H., M.M.A.H., J.D.<br /><searchLink fieldCode="AU" term="%22Hofstraat+SRJ%22">Hofstraat SRJ</searchLink>; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.; These authors contributed equally: T.A., Y.v.E., S.R.J.H., M.M.A.H., J.D.<br /><searchLink fieldCode="AU" term="%22Hendrikx+MMA%22">Hendrikx MMA</searchLink>; Biotrip B.V., Eindhoven, the Netherlands.; These authors contributed equally: T.A., Y.v.E., S.R.J.H., M.M.A.H., J.D.<br /><searchLink fieldCode="AU" term="%22Deckers+J%22">Deckers J</searchLink>; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; These authors contributed equally: T.A., Y.v.E., S.R.J.H., M.M.A.H., J.D.<br /><searchLink fieldCode="AU" term="%22Versteeg+I%22">Versteeg I</searchLink>; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ros+GWB%22">Ros GWB</searchLink>; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kapteijns+MHAP%22">Kapteijns MHAP</searchLink>; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bartelet+BM%22">Bartelet BM</searchLink>; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Zwolsman+R%22">Zwolsman R</searchLink>; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Trines+MM%22">Trines MM</searchLink>; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hoorn+D%22">Hoorn D</searchLink>; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bex+S%22">Bex S</searchLink>; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Houten+P%22">van Houten P</searchLink>; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ziogas+A%22">Ziogas A</searchLink>; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Grao-Roldán+C%22">Grao-Roldán C</searchLink>; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Davighi+GM%22">Davighi GM</searchLink>; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Soultanidis+G%22">Soultanidis G</searchLink>; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Farid+AS%22">Farid AS</searchLink>; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+YH%22">Lee YH</searchLink>; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Voeten+N%22">Voeten N</searchLink>; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.; Department of Obstetrics and Gynecology, Catharina Cancer Institute, Catharina Hospital, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Piek+JMJ%22">Piek JMJ</searchLink>; Department of Obstetrics and Gynecology, Catharina Cancer Institute, Catharina Hospital, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Franssen+GM%22">Franssen GM</searchLink>; Department of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Heskamp+S%22">Heskamp S</searchLink>; Department of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Janssen+HM%22">Janssen HM</searchLink>; SyMO-Chem B.V., Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Fransen+PM%22">Fransen PM</searchLink>; SyMO-Chem B.V., Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Langouo-Fontsa+MD%22">Langouo-Fontsa MD</searchLink>; Molecular Immunology Laboratory, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Garavello+ACM%22">Garavello ACM</searchLink>; Cancer Ecosystems and Metastasis laboratory, Université libre de Bruxelles, Institut Jules Bordet, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Karras+P%22">Karras P</searchLink>; Cancer Ecosystems and Metastasis laboratory, Université libre de Bruxelles, Institut Jules Bordet, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Netea-Maier+RT%22">Netea-Maier RT</searchLink>; Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Pérez-Medina+C%22">Pérez-Medina C</searchLink>; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Fayad+ZA%22">Fayad ZA</searchLink>; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22van+Leent+MMT%22">van Leent MMT</searchLink>; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Teunissen+AJP%22">Teunissen AJP</searchLink>; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Rashidian+M%22">Rashidian M</searchLink>; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kluza+E%22">Kluza E</searchLink>; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Toner+YC%22">Toner YC</searchLink>; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Priem+B%22">Priem B</searchLink>; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kreijtz+JHCM%22">Kreijtz JHCM</searchLink>; Biotrip B.V., Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Beldman+TJ%22">Beldman TJ</searchLink>; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Netea+MG%22">Netea MG</searchLink>; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22van+der+Meel+R%22">van der Meel R</searchLink>; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Mulder+WJM%22">Mulder WJM</searchLink>; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
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