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Symptom-specific genetics reveal heterogeneity within major depressive disorder.

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Title: Symptom-specific genetics reveal heterogeneity within major depressive disorder.
Authors: Goula AA; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Amsterdam Neuroscience Research Institute, Amsterdam, the Netherlands., Huider F; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Department of Biological Psychology, Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, 1081 Amsterdam, the Netherlands., Hottenga JJ; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Department of Biological Psychology, Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, 1081 Amsterdam, the Netherlands.; Neurological Disorder Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar., Pasman JA; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Amsterdam Neuroscience Research Institute, Amsterdam, the Netherlands.; Department of Psychiatry, Amsterdam UMC location University of Amsterdam, 1105 Amsterdam, the Netherlands., Bot M; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands., Rietman ML; Center for Prevention, Lifestyle and Health, Dutch National Institute for Public Health and the Environment, 3721 Bilthoven, the Netherlands., 't Hart LM; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Department of Epidemiology and Data Science, Amsterdam UMC location Vrije Universiteit, 1081 Amsterdam, the Netherlands.; Department of Cell and Chemical Biology & Department of Biomedical Data Sciences, section Molecular Epidemiology, Leiden University Medical Center, 2333 Leiden, the Netherlands., Rutters F; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Department of Epidemiology and Data Science, Amsterdam UMC location Vrije Universiteit, 1081 Amsterdam, the Netherlands., Blom MT; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Department of General Practice, Amsterdam UMC, 1081 Amsterdam, the Netherlands., Rhebergen D; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Mental health Institute GGz Centraal, Amersfoort, the Netherlands., Visser M; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, 1081 Amsterdam, the Netherlands., Hartman CA; Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9713 Groningen, the Netherlands., Oldehinkel AJ; Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9713 Groningen, the Netherlands., de Geus EJC; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Department of Biological Psychology, Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, 1081 Amsterdam, the Netherlands., Franke B; Departments of Medical Neuroscience and Human Genetics, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 Nijmegen, The Netherlands., Picavet HSJ; Center for Prevention, Lifestyle and Health, Dutch National Institute for Public Health and the Environment, 3721 Bilthoven, the Netherlands., Verschuren WMM; Center for Prevention, Lifestyle and Health, Dutch National Institute for Public Health and the Environment, 3721 Bilthoven, the Netherlands.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 Utrecht, the Netherlands., van Loo HM; Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9713 Groningen, the Netherlands., Boomsma DΙ; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research Vrije Universiteit Amsterdam, The Netherlands., Penninx BWJH; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands., Milaneschi Y; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Amsterdam Neuroscience Research Institute, Amsterdam, the Netherlands.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Mar 25. Date of Electronic Publication: 2026 Mar 25.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Symptom-specific genetics reveal heterogeneity within major depressive disorder.
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  Data: <searchLink fieldCode="AU" term="%22Goula+AA%22">Goula AA</searchLink>; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Amsterdam Neuroscience Research Institute, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Huider+F%22">Huider F</searchLink>; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Department of Biological Psychology, Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, 1081 Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hottenga+JJ%22">Hottenga JJ</searchLink>; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Department of Biological Psychology, Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, 1081 Amsterdam, the Netherlands.; Neurological Disorder Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar.<br /><searchLink fieldCode="AU" term="%22Pasman+JA%22">Pasman JA</searchLink>; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Amsterdam Neuroscience Research Institute, Amsterdam, the Netherlands.; Department of Psychiatry, Amsterdam UMC location University of Amsterdam, 1105 Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bot+M%22">Bot M</searchLink>; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Rietman+ML%22">Rietman ML</searchLink>; Center for Prevention, Lifestyle and Health, Dutch National Institute for Public Health and the Environment, 3721 Bilthoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22't+Hart+LM%22">'t Hart LM</searchLink>; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Department of Epidemiology and Data Science, Amsterdam UMC location Vrije Universiteit, 1081 Amsterdam, the Netherlands.; Department of Cell and Chemical Biology & Department of Biomedical Data Sciences, section Molecular Epidemiology, Leiden University Medical Center, 2333 Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Rutters+F%22">Rutters F</searchLink>; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Department of Epidemiology and Data Science, Amsterdam UMC location Vrije Universiteit, 1081 Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Blom+MT%22">Blom MT</searchLink>; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Department of General Practice, Amsterdam UMC, 1081 Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Rhebergen+D%22">Rhebergen D</searchLink>; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Mental health Institute GGz Centraal, Amersfoort, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Visser+M%22">Visser M</searchLink>; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, 1081 Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hartman+CA%22">Hartman CA</searchLink>; Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9713 Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Oldehinkel+AJ%22">Oldehinkel AJ</searchLink>; Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9713 Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Geus+EJC%22">de Geus EJC</searchLink>; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Department of Biological Psychology, Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, 1081 Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Franke+B%22">Franke B</searchLink>; Departments of Medical Neuroscience and Human Genetics, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Picavet+HSJ%22">Picavet HSJ</searchLink>; Center for Prevention, Lifestyle and Health, Dutch National Institute for Public Health and the Environment, 3721 Bilthoven, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Verschuren+WMM%22">Verschuren WMM</searchLink>; Center for Prevention, Lifestyle and Health, Dutch National Institute for Public Health and the Environment, 3721 Bilthoven, the Netherlands.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Loo+HM%22">van Loo HM</searchLink>; Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9713 Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Boomsma+DΙ%22">Boomsma DΙ</searchLink>; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research Vrije Universiteit Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Penninx+BWJH%22">Penninx BWJH</searchLink>; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Milaneschi+Y%22">Milaneschi Y</searchLink>; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, 1105 Amsterdam, the Netherlands.; Amsterdam Neuroscience Research Institute, Amsterdam, the Netherlands.
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