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Sphingolipid-associated signature unveils TIMP1-driven temozolomide resistance and guides stratified therapy in glioblastoma.

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Title: Sphingolipid-associated signature unveils TIMP1-driven temozolomide resistance and guides stratified therapy in glioblastoma.
Authors: Lyu F; Department of Radiology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.; German Center for Neurodegenerative Diseases (DZNE), Medical Faculty, University of Bonn, Bonn, Germany.; Department of Neurosurgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China., Wu J; German Center for Neurodegenerative Diseases (DZNE), Medical Faculty, University of Bonn, Bonn, Germany.; Institute of Nervous System Diseases, Xuzhou Medical University, Xuzhou, Jiangsu, China.; Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China., Qi J; Institute of Nervous System Diseases, Xuzhou Medical University, Xuzhou, Jiangsu, China., Wang G; German Center for Neurodegenerative Diseases (DZNE), Medical Faculty, University of Bonn, Bonn, Germany., Xie L; German Center for Neurodegenerative Diseases (DZNE), Medical Faculty, University of Bonn, Bonn, Germany.; Department of Child Healthcare, Children's Hospital of Fudan University (Xiamen Branch), Xiamen Children's Hospital, Xiamen, China., Wang Z; Department of Radiology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.; German Center for Neurodegenerative Diseases (DZNE), Medical Faculty, University of Bonn, Bonn, Germany.
Source: Frontiers in immunology [Front Immunol] 2026 Mar 18; Vol. 17, pp. 1753274. Date of Electronic Publication: 2026 Mar 18 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Sphingolipid-associated signature unveils TIMP1-driven temozolomide resistance and guides stratified therapy in glioblastoma.
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  Data: <searchLink fieldCode="AU" term="%22Lyu+F%22">Lyu F</searchLink>; Department of Radiology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.; German Center for Neurodegenerative Diseases (DZNE), Medical Faculty, University of Bonn, Bonn, Germany.; Department of Neurosurgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Medical Faculty, University of Bonn, Bonn, Germany.; Institute of Nervous System Diseases, Xuzhou Medical University, Xuzhou, Jiangsu, China.; Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Qi+J%22">Qi J</searchLink>; Institute of Nervous System Diseases, Xuzhou Medical University, Xuzhou, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Wang+G%22">Wang G</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Medical Faculty, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Xie+L%22">Xie L</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Medical Faculty, University of Bonn, Bonn, Germany.; Department of Child Healthcare, Children's Hospital of Fudan University (Xiamen Branch), Xiamen Children's Hospital, Xiamen, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Radiology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.; German Center for Neurodegenerative Diseases (DZNE), Medical Faculty, University of Bonn, Bonn, Germany.
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              Text: 2026 Mar 18
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