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NDUFS1-Mediated Mitochondrial Complex I Activity Maintains Pancreatic Cancer Stemness by Promoting PAX2 Hypomethylation.

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Title: NDUFS1-Mediated Mitochondrial Complex I Activity Maintains Pancreatic Cancer Stemness by Promoting PAX2 Hypomethylation.
Authors: Fan XY; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China., Li W; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China., Shi Y; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China., Xu BQ; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.; The 900th Hospital of Joint Logistics Support Force Fuzhou China., Wang H; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China., Tian RF; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China., Duan ZC; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China., Fan J; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China., Liu JR; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China., Sun XX; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China., Wang B; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China., Wang LJ; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China., Wang K; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China., Wang SJ; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China., Yang XM; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China., Cui HY; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China., Chen ZN; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China., Li L; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.
Source: MedComm [MedComm (2020)] 2026 Mar 18; Vol. 7 (4), pp. e70678. Date of Electronic Publication: 2026 Mar 18 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Inc Country of Publication: China NLM ID: 101769925 Publication Model: eCollection Cited Medium: Internet ISSN: 2688-2663 (Electronic) Linking ISSN: 26882663 NLM ISO Abbreviation: MedComm (2020) Subsets: PubMed not MEDLINE
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  Data: NDUFS1-Mediated Mitochondrial Complex I Activity Maintains Pancreatic Cancer Stemness by Promoting PAX2 Hypomethylation.
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  Data: <searchLink fieldCode="AU" term="%22Fan+XY%22">Fan XY</searchLink>; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.<br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.<br /><searchLink fieldCode="AU" term="%22Shi+Y%22">Shi Y</searchLink>; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.<br /><searchLink fieldCode="AU" term="%22Xu+BQ%22">Xu BQ</searchLink>; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.; The 900th Hospital of Joint Logistics Support Force Fuzhou China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.<br /><searchLink fieldCode="AU" term="%22Tian+RF%22">Tian RF</searchLink>; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.<br /><searchLink fieldCode="AU" term="%22Duan+ZC%22">Duan ZC</searchLink>; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.<br /><searchLink fieldCode="AU" term="%22Fan+J%22">Fan J</searchLink>; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.<br /><searchLink fieldCode="AU" term="%22Liu+JR%22">Liu JR</searchLink>; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.<br /><searchLink fieldCode="AU" term="%22Sun+XX%22">Sun XX</searchLink>; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.<br /><searchLink fieldCode="AU" term="%22Wang+B%22">Wang B</searchLink>; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.<br /><searchLink fieldCode="AU" term="%22Wang+LJ%22">Wang LJ</searchLink>; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.<br /><searchLink fieldCode="AU" term="%22Wang+K%22">Wang K</searchLink>; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.<br /><searchLink fieldCode="AU" term="%22Wang+SJ%22">Wang SJ</searchLink>; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.<br /><searchLink fieldCode="AU" term="%22Yang+XM%22">Yang XM</searchLink>; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.<br /><searchLink fieldCode="AU" term="%22Cui+HY%22">Cui HY</searchLink>; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.<br /><searchLink fieldCode="AU" term="%22Chen+ZN%22">Chen ZN</searchLink>; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Department of Cell Biology National Translational Science Center for Molecular Medicine State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancer State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical University Xi'an China.
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