Upstream ORFs control TNFR1 abundance and tissue tolerance to TNF.

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Title: Upstream ORFs control TNFR1 abundance and tissue tolerance to TNF.
Authors: Ma B; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Lyu W; LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Rizk J; LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Han X; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Kjær M; LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Pereira Almeida V; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Jessen M; LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Sauerland MB; LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Leung CSK; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Centre for Immuno-Oncology, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Van den Eynde BJ; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Ludwig Institute for Cancer Research, de Duve Institute, UCLouvain, Brussels, Belgium.; WELBIO Department, WEL Research Institute, Brussels, Belgium., Lu X; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Gyrd-Hansen M; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Source: Science immunology [Sci Immunol] 2026 Apr 03; Vol. 11 (118), pp. eaeb6484. Date of Electronic Publication: 2026 Apr 03.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2470-9468
DOI:10.1126/sciimmunol.aeb6484