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Claudins interact with LILRB immune inhibitory receptors to promote myeloid immunosuppression in cancer.

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Title: Claudins interact with LILRB immune inhibitory receptors to promote myeloid immunosuppression in cancer.
Authors: Liu X; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Huang R; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Ku Z; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, USA., Xie J; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Chen H; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA., He Y; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Lou Q; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Zhang C; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Yang X; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Lewis C; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA., Homsi J; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Gupta A; Center for Alzheimer's and Neurodegenerative Diseases, UT Southwestern Medical Center, Dallas, TX, USA., Dong L; Quantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA., Chen K; Quantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA., Tu A; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Du L; Children's Research Institute and the Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA., Yu H; Department of Biophysics, UT Southwestern Medical Center, Dallas, TX, USA., Hu Q; Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA., Fang M; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Li B; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Khan AEMA; Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA., Simith C; Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA., John S; Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA., Xu L; Quantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA., Zhang N; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, USA., An Z; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, USA., Zhang CC; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Source: Science immunology [Sci Immunol] 2026 Apr 03; Vol. 11 (118), pp. eadt7832. Date of Electronic Publication: 2026 Apr 03.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
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  Data: Claudins interact with LILRB immune inhibitory receptors to promote myeloid immunosuppression in cancer.
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  Data: <searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Huang+R%22">Huang R</searchLink>; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ku+Z%22">Ku Z</searchLink>; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Xie+J%22">Xie J</searchLink>; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Lou+Q%22">Lou Q</searchLink>; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Lewis+C%22">Lewis C</searchLink>; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Homsi+J%22">Homsi J</searchLink>; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Gupta+A%22">Gupta A</searchLink>; Center for Alzheimer's and Neurodegenerative Diseases, UT Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Dong+L%22">Dong L</searchLink>; Quantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; Quantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Tu+A%22">Tu A</searchLink>; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Du+L%22">Du L</searchLink>; Children's Research Institute and the Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Yu+H%22">Yu H</searchLink>; Department of Biophysics, UT Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Hu+Q%22">Hu Q</searchLink>; Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Fang+M%22">Fang M</searchLink>; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Li+B%22">Li B</searchLink>; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Khan+AEMA%22">Khan AEMA</searchLink>; Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Simith+C%22">Simith C</searchLink>; Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22John+S%22">John S</searchLink>; Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Xu+L%22">Xu L</searchLink>; Quantitative Biomedical Research Center, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+N%22">Zhang N</searchLink>; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22An+Z%22">An Z</searchLink>; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+CC%22">Zhang CC</searchLink>; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
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