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TROP2/claudin program mediates immune exclusion to impede checkpoint blockade in breast cancer.

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Title: TROP2/claudin program mediates immune exclusion to impede checkpoint blockade in breast cancer.
Authors: Wu B; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA lellisen@mgh.harvard.edu wu.bogang@mayo.edu.; Department of Immunology, Mayo Clinic Arizona, Phoenix, Arizona, USA., Thant W; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.; Department of Immunology, Mayo Clinic Arizona, Phoenix, Arizona, USA., Bitman E; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Liu T; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Liu J; Department of Immunology, Mayo Clinic Arizona, Phoenix, Arizona, USA.; Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA., Paschalis EI; Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA., Patel BK; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Nawrocki C; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Xu KH; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Nieman LT; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Ting DT; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., de Gois Macedo B; Department of Immunology, Mayo Clinic Arizona, Phoenix, Arizona, USA., Cheng Y; Department of Immunology, Mayo Clinic Arizona, Phoenix, Arizona, USA., Jiang K; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Sun F; Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Thimmiah N; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Sun S; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Abelman RO; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Bossuyt VI; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Isakoff SJ; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Spring LM; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Bardia A; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Ellisen LW; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA lellisen@mgh.harvard.edu wu.bogang@mayo.edu.; Ludwig Center at Harvard, Boston, Massachusetts, USA.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2026 Apr 03; Vol. 14 (4). Date of Electronic Publication: 2026 Apr 03.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TROP2/claudin program mediates immune exclusion to impede checkpoint blockade in breast cancer.
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  Data: <searchLink fieldCode="AU" term="%22Wu+B%22">Wu B</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA lellisen@mgh.harvard.edu wu.bogang@mayo.edu.; Department of Immunology, Mayo Clinic Arizona, Phoenix, Arizona, USA.<br /><searchLink fieldCode="AU" term="%22Thant+W%22">Thant W</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.; Department of Immunology, Mayo Clinic Arizona, Phoenix, Arizona, USA.<br /><searchLink fieldCode="AU" term="%22Bitman+E%22">Bitman E</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Liu+T%22">Liu T</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Immunology, Mayo Clinic Arizona, Phoenix, Arizona, USA.; Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Paschalis+EI%22">Paschalis EI</searchLink>; Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Patel+BK%22">Patel BK</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Nawrocki+C%22">Nawrocki C</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Xu+KH%22">Xu KH</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Nieman+LT%22">Nieman LT</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Ting+DT%22">Ting DT</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22de+Gois+Macedo+B%22">de Gois Macedo B</searchLink>; Department of Immunology, Mayo Clinic Arizona, Phoenix, Arizona, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+Y%22">Cheng Y</searchLink>; Department of Immunology, Mayo Clinic Arizona, Phoenix, Arizona, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+K%22">Jiang K</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Sun+F%22">Sun F</searchLink>; Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Thimmiah+N%22">Thimmiah N</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Sun+S%22">Sun S</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Abelman+RO%22">Abelman RO</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Bossuyt+VI%22">Bossuyt VI</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Isakoff+SJ%22">Isakoff SJ</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Spring+LM%22">Spring LM</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Bardia+A%22">Bardia A</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Ellisen+LW%22">Ellisen LW</searchLink>; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA lellisen@mgh.harvard.edu wu.bogang@mayo.edu.; Ludwig Center at Harvard, Boston, Massachusetts, USA.
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  Data: <searchLink fieldCode="JN" term="%22101620585%22">Journal for immunotherapy of cancer</searchLink> [J Immunother Cancer] 2026 Apr 03; Vol. 14 (4). <i>Date of Electronic Publication: </i>2026 Apr 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group+Ltd%22">BMJ Publishing Group Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101620585 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-1426 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220511426%22">20511426 </searchLink><i>NLM ISO Abbreviation: </i>J Immunother Cancer <i>Subsets: </i>MEDLINE
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        Value: 10.1136/jitc-2025-012265
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        Text: English
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      – TitleFull: TROP2/claudin program mediates immune exclusion to impede checkpoint blockade in breast cancer.
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              Text: 2026 Apr 03
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